| UniProt ID | NSP1_YEAST | |
|---|---|---|
| UniProt AC | P14907 | |
| Protein Name | Nucleoporin NSP1 | |
| Gene Name | NSP1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 823 | |
| Subcellular Localization |
Nucleus, nuclear pore complex. Nucleus membrane Peripheral membrane protein Cytoplasmic side. Nucleus membrane Peripheral membrane protein Nucleoplasmic side. Symmetric distribution. |
|
| Protein Description | Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). NSP1 plays an important role in several nuclear transport pathways including poly(A)+ RNA, tRNA, pre-ribosome, signal recognition particle (SRP), and protein transport.. | |
| Protein Sequence | MNFNTPQQNKTPFSFGTANNNSNTTNQNSSTGAGAFGTGQSTFGFNNSAPNNTNNANSSITPAFGSNNTGNTAFGNSNPTSNVFGSNNSTTNTFGSNSAGTSLFGSSSAQQTKSNGTAGGNTFGSSSLFNNSTNSNTTKPAFGGLNFGGGNNTTPSSTGNANTSNNLFGATANANKPAFSFGATTNDDKKTEPDKPAFSFNSSVGNKTDAQAPTTGFSFGSQLGGNKTVNEAAKPSLSFGSGSAGANPAGASQPEPTTNEPAKPALSFGTATSDNKTTNTTPSFSFGAKSDENKAGATSKPAFSFGAKPEEKKDDNSSKPAFSFGAKSNEDKQDGTAKPAFSFGAKPAEKNNNETSKPAFSFGAKSDEKKDGDASKPAFSFGAKPDENKASATSKPAFSFGAKPEEKKDDNSSKPAFSFGAKSNEDKQDGTAKPAFSFGAKPAEKNNNETSKPAFSFGAKSDEKKDGDASKPAFSFGAKSDEKKDSDSSKPAFSFGTKSNEKKDSGSSKPAFSFGAKPDEKKNDEVSKPAFSFGAKANEKKESDESKSAFSFGSKPTGKEEGDGAKAAISFGAKPEEQKSSDTSKPAFTFGAQKDNEKKTEESSTGKSTADVKSSDSLKLNSKPVELKPVSLDNKTLDDLVTKWTNQLTESASHFEQYTKKINSWDQVLVKGGEQISQLYSDAVMAEHSQNKIDQSLQYIERQQDELENFLDNFETKTEALLSDVVSTSSGAAANNNDQKRQQAYKTAQTLDENLNSLSSNLSSLIVEINNVSNTFNKTTNIDINNEDENIQLIKILNSHFDALRSLDDNSTSLEKQINSIKK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 5 | Phosphorylation | ---MNFNTPQQNKTP ---CCCCCCCCCCCC | 20.52 | 24909858 | |
| 122 | Phosphorylation | NGTAGGNTFGSSSLF CCCCCCCCCCCHHHC | 32.42 | 28889911 | |
| 127 | Phosphorylation | GNTFGSSSLFNNSTN CCCCCCHHHCCCCCC | 38.38 | 28889911 | |
| 180 | Phosphorylation | NANKPAFSFGATTND CCCCCCEECCCCCCC | 25.52 | 21126336 | |
| 202 | Phosphorylation | KPAFSFNSSVGNKTD CCCCEECCCCCCCCC | 25.12 | 30377154 | |
| 214 | Phosphorylation | KTDAQAPTTGFSFGS CCCCCCCCCCCCCCH | 42.43 | 30377154 | |
| 215 | Phosphorylation | TDAQAPTTGFSFGSQ CCCCCCCCCCCCCHH | 34.86 | 30377154 | |
| 218 | Phosphorylation | QAPTTGFSFGSQLGG CCCCCCCCCCHHCCC | 30.00 | 21551504 | |
| 221 | Phosphorylation | TTGFSFGSQLGGNKT CCCCCCCHHCCCCCC | 21.88 | 23749301 | |
| 227 | Ubiquitination | GSQLGGNKTVNEAAK CHHCCCCCCCCHHCC | 58.06 | 15699485 | |
| 234 | Ubiquitination | KTVNEAAKPSLSFGS CCCCHHCCCCCCCCC | 42.03 | 15699485 | |
| 236 | Phosphorylation | VNEAAKPSLSFGSGS CCHHCCCCCCCCCCC | 35.62 | 30377154 | |
| 238 | Phosphorylation | EAAKPSLSFGSGSAG HHCCCCCCCCCCCCC | 31.72 | 28889911 | |
| 241 | Phosphorylation | KPSLSFGSGSAGANP CCCCCCCCCCCCCCC | 27.80 | 30377154 | |
| 243 | Phosphorylation | SLSFGSGSAGANPAG CCCCCCCCCCCCCCC | 25.81 | 21440633 | |
| 257 | Phosphorylation | GASQPEPTTNEPAKP CCCCCCCCCCCCCCC | 40.36 | 30377154 | |
| 258 | Phosphorylation | ASQPEPTTNEPAKPA CCCCCCCCCCCCCCC | 48.58 | 21440633 | |
| 267 | Phosphorylation | EPAKPALSFGTATSD CCCCCCCCCEEECCC | 24.60 | 21551504 | |
| 270 | Phosphorylation | KPALSFGTATSDNKT CCCCCCEEECCCCCC | 25.42 | 30377154 | |
| 272 | Phosphorylation | ALSFGTATSDNKTTN CCCCEEECCCCCCCC | 36.13 | 30377154 | |
| 273 | Phosphorylation | LSFGTATSDNKTTNT CCCEEECCCCCCCCC | 36.40 | 21551504 | |
| 277 | Phosphorylation | TATSDNKTTNTTPSF EECCCCCCCCCCCCE | 31.37 | 22369663 | |
| 278 | Phosphorylation | ATSDNKTTNTTPSFS ECCCCCCCCCCCCEE | 31.98 | 22369663 | |
| 280 | Phosphorylation | SDNKTTNTTPSFSFG CCCCCCCCCCCEECC | 37.68 | 22369663 | |
| 281 | Phosphorylation | DNKTTNTTPSFSFGA CCCCCCCCCCEECCC | 21.00 | 22369663 | |
| 283 | Phosphorylation | KTTNTTPSFSFGAKS CCCCCCCCEECCCCC | 31.28 | 22369663 | |
| 285 | Phosphorylation | TNTTPSFSFGAKSDE CCCCCCEECCCCCCC | 27.40 | 22369663 | |
| 289 | Acetylation | PSFSFGAKSDENKAG CCEECCCCCCCCCCC | 59.84 | 25381059 | |
| 290 | Phosphorylation | SFSFGAKSDENKAGA CEECCCCCCCCCCCC | 50.01 | 22369663 | |
| 300 | Acetylation | NKAGATSKPAFSFGA CCCCCCCCCCCCCCC | 35.69 | 24489116 | |
| 304 | Phosphorylation | ATSKPAFSFGAKPEE CCCCCCCCCCCCCHH | 25.52 | 24909858 | |
| 308 | Acetylation | PAFSFGAKPEEKKDD CCCCCCCCCHHCCCC | 54.03 | 24489116 | |
| 317 | Phosphorylation | EEKKDDNSSKPAFSF HHCCCCCCCCCCCCC | 46.89 | 25704821 | |
| 323 | Phosphorylation | NSSKPAFSFGAKSNE CCCCCCCCCCCCCCC | 25.52 | 21440633 | |
| 327 | Acetylation | PAFSFGAKSNEDKQD CCCCCCCCCCCCCCC | 54.94 | 25381059 | |
| 328 | Phosphorylation | AFSFGAKSNEDKQDG CCCCCCCCCCCCCCC | 44.94 | 25704821 | |
| 332 | Acetylation | GAKSNEDKQDGTAKP CCCCCCCCCCCCCCC | 44.07 | 24489116 | |
| 342 | Phosphorylation | GTAKPAFSFGAKPAE CCCCCCCCCCCCCCC | 25.52 | 21440633 | |
| 355 | Phosphorylation | AEKNNNETSKPAFSF CCCCCCCCCCCCCCC | 44.14 | 21440633 | |
| 361 | Phosphorylation | ETSKPAFSFGAKSDE CCCCCCCCCCCCCCC | 25.52 | 22369663 | |
| 365 | Acetylation | PAFSFGAKSDEKKDG CCCCCCCCCCCCCCC | 59.84 | 25381059 | |
| 365 | Succinylation | PAFSFGAKSDEKKDG CCCCCCCCCCCCCCC | 59.84 | 23954790 | |
| 366 | Phosphorylation | AFSFGAKSDEKKDGD CCCCCCCCCCCCCCC | 50.93 | 20377248 | |
| 375 | Phosphorylation | EKKDGDASKPAFSFG CCCCCCCCCCCCCCC | 43.86 | 28889911 | |
| 380 | Phosphorylation | DASKPAFSFGAKPDE CCCCCCCCCCCCCCC | 25.52 | 21440633 | |
| 399 | Phosphorylation | ATSKPAFSFGAKPEE CCCCCCCCCCCCCCC | 25.52 | 24909858 | |
| 412 | Phosphorylation | EEKKDDNSSKPAFSF CCCCCCCCCCCCCCC | 46.89 | 25704821 | |
| 418 | Phosphorylation | NSSKPAFSFGAKSNE CCCCCCCCCCCCCCC | 25.52 | 21440633 | |
| 422 | Acetylation | PAFSFGAKSNEDKQD CCCCCCCCCCCCCCC | 54.94 | 25381059 | |
| 423 | Phosphorylation | AFSFGAKSNEDKQDG CCCCCCCCCCCCCCC | 44.94 | 25704821 | |
| 437 | Phosphorylation | GTAKPAFSFGAKPAE CCCCCCCCCCCCCCC | 25.52 | 21440633 | |
| 450 | Phosphorylation | AEKNNNETSKPAFSF CCCCCCCCCCCCCCC | 44.14 | 21440633 | |
| 456 | Phosphorylation | ETSKPAFSFGAKSDE CCCCCCCCCCCCCCC | 25.52 | 22369663 | |
| 460 | Acetylation | PAFSFGAKSDEKKDG CCCCCCCCCCCCCCC | 59.84 | 25381059 | |
| 461 | Phosphorylation | AFSFGAKSDEKKDGD CCCCCCCCCCCCCCC | 50.93 | 20377248 | |
| 470 | Phosphorylation | EKKDGDASKPAFSFG CCCCCCCCCCCCCCC | 43.86 | 19779198 | |
| 475 | Phosphorylation | DASKPAFSFGAKSDE CCCCCCCCCCCCCCC | 25.52 | 21440633 | |
| 479 | Acetylation | PAFSFGAKSDEKKDS CCCCCCCCCCCCCCC | 59.84 | 25381059 | |
| 480 | Phosphorylation | AFSFGAKSDEKKDSD CCCCCCCCCCCCCCC | 50.93 | 21440633 | |
| 486 | Phosphorylation | KSDEKKDSDSSKPAF CCCCCCCCCCCCCCC | 48.55 | 21440633 | |
| 494 | Phosphorylation | DSSKPAFSFGTKSNE CCCCCCCCCCCCCCC | 25.52 | 30377154 | |
| 498 | Acetylation | PAFSFGTKSNEKKDS CCCCCCCCCCCCCCC | 52.22 | 25381059 | |
| 513 | Phosphorylation | GSSKPAFSFGAKPDE CCCCCCCCCCCCCCC | 25.52 | 21440633 | |
| 517 | Acetylation | PAFSFGAKPDEKKND CCCCCCCCCCCCCCC | 54.07 | 24489116 | |
| 528 | Acetylation | KKNDEVSKPAFSFGA CCCCCCCCCCHHCCC | 45.61 | 24489116 | |
| 532 | Phosphorylation | EVSKPAFSFGAKANE CCCCCCHHCCCCCCC | 25.52 | 21440633 | |
| 536 | Acetylation | PAFSFGAKANEKKES CCHHCCCCCCCCCCC | 52.72 | 25381059 | |
| 547 | Ubiquitination | KKESDESKSAFSFGS CCCCHHHHCCCCCCC | 43.70 | 15699485 | |
| 551 | Phosphorylation | DESKSAFSFGSKPTG HHHHCCCCCCCCCCC | 28.54 | 21440633 | |
| 554 | Phosphorylation | KSAFSFGSKPTGKEE HCCCCCCCCCCCCCC | 33.19 | 21440633 | |
| 555 | Ubiquitination | SAFSFGSKPTGKEEG CCCCCCCCCCCCCCC | 47.15 | 15699485 | |
| 559 | Ubiquitination | FGSKPTGKEEGDGAK CCCCCCCCCCCCCHH | 55.88 | 15699485 | |
| 566 | Ubiquitination | KEEGDGAKAAISFGA CCCCCCHHHHHHCCC | 43.83 | 15699485 | |
| 566 | Acetylation | KEEGDGAKAAISFGA CCCCCCHHHHHHCCC | 43.83 | 25381059 | |
| 570 | Phosphorylation | DGAKAAISFGAKPEE CCHHHHHHCCCCHHH | 16.95 | 21440633 | |
| 581 | Phosphorylation | KPEEQKSSDTSKPAF CHHHHCCCCCCCCCC | 52.52 | 21082442 | |
| 585 | Acetylation | QKSSDTSKPAFTFGA HCCCCCCCCCCCCCC | 42.32 | 24489116 | |
| 608 | Phosphorylation | EESSTGKSTADVKSS CCCCCCCCHHCCCCC | 30.12 | 23749301 | |
| 613 | Ubiquitination | GKSTADVKSSDSLKL CCCHHCCCCCCCCCC | 44.80 | 23749301 | |
| 614 | Phosphorylation | KSTADVKSSDSLKLN CCHHCCCCCCCCCCC | 38.95 | 23749301 | |
| 617 | Phosphorylation | ADVKSSDSLKLNSKP HCCCCCCCCCCCCCC | 29.38 | 19779198 | |
| 622 | Phosphorylation | SDSLKLNSKPVELKP CCCCCCCCCCCEECE | 49.09 | 21440633 | |
| 623 | Ubiquitination | DSLKLNSKPVELKPV CCCCCCCCCCEECEE | 52.59 | 23749301 | |
| 623 | Acetylation | DSLKLNSKPVELKPV CCCCCCCCCCEECEE | 52.59 | 24489116 | |
| 628 | Acetylation | NSKPVELKPVSLDNK CCCCCEECEECCCCC | 29.84 | 24489116 | |
| 631 | Phosphorylation | PVELKPVSLDNKTLD CCEECEECCCCCCHH | 38.23 | 21440633 | |
| 659 | Phosphorylation | ASHFEQYTKKINSWD HHHHHHHHHHCCCHH | 26.09 | 30377154 | |
| 660 | Acetylation | SHFEQYTKKINSWDQ HHHHHHHHHCCCHHH | 46.88 | 24489116 | |
| 664 | Phosphorylation | QYTKKINSWDQVLVK HHHHHCCCHHHEEEE | 35.19 | 22369663 | |
| 689 | Phosphorylation | DAVMAEHSQNKIDQS HHHHHHHHHHHHHHH | 27.27 | 28889911 | |
| 692 | Acetylation | MAEHSQNKIDQSLQY HHHHHHHHHHHHHHH | 39.77 | 24489116 | |
| 718 | Phosphorylation | LDNFETKTEALLSDV HHHHHHHHHHHHHHH | 33.63 | 22369663 | |
| 723 | Phosphorylation | TKTEALLSDVVSTSS HHHHHHHHHHHHHCC | 29.25 | 22369663 | |
| 727 | Phosphorylation | ALLSDVVSTSSGAAA HHHHHHHHHCCCHHH | 23.55 | 22369663 | |
| 728 | Phosphorylation | LLSDVVSTSSGAAAN HHHHHHHHCCCHHHC | 18.46 | 22369663 | |
| 729 | Phosphorylation | LSDVVSTSSGAAANN HHHHHHHCCCHHHCC | 21.19 | 22369663 | |
| 730 | Phosphorylation | SDVVSTSSGAAANNN HHHHHHCCCHHHCCC | 32.32 | 25521595 | |
| 740 | Acetylation | AANNNDQKRQQAYKT HHCCCHHHHHHHHHH | 55.85 | 24489116 | |
| 779 | Phosphorylation | VSNTFNKTTNIDINN CCCCCCCCCCEECCC | 26.61 | 28132839 | |
| 780 | Phosphorylation | SNTFNKTTNIDINNE CCCCCCCCCEECCCC | 31.61 | 28132839 | |
| 795 | Ubiquitination | DENIQLIKILNSHFD HHHHHHHHHHHHHHH | 50.13 | 23749301 | |
| 806 | Phosphorylation | SHFDALRSLDDNSTS HHHHHHHHCCCCCHH | 36.68 | 21440633 | |
| 811 | Phosphorylation | LRSLDDNSTSLEKQI HHHCCCCCHHHHHHH | 26.77 | 22369663 | |
| 812 | Phosphorylation | RSLDDNSTSLEKQIN HHCCCCCHHHHHHHH | 43.52 | 24909858 | |
| 813 | Phosphorylation | SLDDNSTSLEKQINS HCCCCCHHHHHHHHH | 34.06 | 22369663 | |
| 816 | Ubiquitination | DNSTSLEKQINSIKK CCCHHHHHHHHHHCC | 62.87 | 24961812 | |
| 816 | Acetylation | DNSTSLEKQINSIKK CCCHHHHHHHHHHCC | 62.87 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NSP1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NSP1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NSP1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-221; SER-238; THR-281;SER-283; SER-285; SER-375; SER-456; SER-570; SER-622; THR-728; SER-729AND SER-730, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-456, AND MASSSPECTROMETRY. | |
