IOC2_YEAST - dbPTM
IOC2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID IOC2_YEAST
UniProt AC Q12072
Protein Name ISWI one complex protein 2
Gene Name IOC2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 812
Subcellular Localization Nucleus .
Protein Description Functions as component of the ISW1B complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW1B complex acts within coding regions to control the amount of RNA polymerase II released into productive elongation and to coordinate elongation with termination and pre-mRNA processing..
Protein Sequence MRTKRTRGTRNVGASMPAGAANADSEDWKEYVSEDIIAQLNKHQLPYSEILDEKIADLANHWHFQYVMAWLSNVCESYTTTTFNTDQYGGSSTKCLWKNIKFDEGVFVTDVFSKIDGKDSNYYNDEVDVDEGSQNLYDRIRLQLLHQLAGNKSGQLKDWNVIVNHHLQNSSAYSDLVTDLPFLELEIARQFDIIYSIIKLIEMKNMIFKNYLANNLHLFTFSEVILDDDNSGGEEMKSLFALPNVGVLVKKTIHRVKEGSSSQVSQTLNIPIKLQNCTIKESDPDIPDSVELIHLEYSHDIDAYLQSITIDYDVITTNWGSMLEYWSENKSSKAIDEFITNLIPVYAEHRLYSAKLLANREKERAIAELMTRRKRSSRLVAKEEENKKKDLESEWFEKLDEREQFIRHRNKLVSKEIKKIKDLLWNQLWQLYDQDYRDEKLTRRNELKDRSGSGTPFFETSLGREEDNPLNEIDIGVLDHGPNFQSSIIPVEPPIPGTVGPLQTGDVPELPSDFCITKEELDELANYGIFTPQQEPDNQDSVFQCPGEPELAPMIITEDTETDLFNNRPLICCDHCYRWQHWECQPPKIIELISSTTKSPQHTLSQRDFGVIIMGNSHGNRRSSRRPQSTLEPSTKSSRPTDKRKPLSECSTFICAWCIRDLELELRNIFVPELKIIRAKQRKQQEDRERRKKMKEEKKRLEELAKKRELTESVSPPVFNNAFANMSSSTTPSIAAYEKTNPAINPAPNVNAAHPIITYSQQTGSKTVPQAPQAPQTSQASIQPQQQQQQQQQQQPLHPKEQNFHFQFPPTN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
260PhosphorylationIHRVKEGSSSQVSQT
EEHHCCCCCCHHHHC		28.1021440633
261PhosphorylationHRVKEGSSSQVSQTL
EHHCCCCCCHHHHCC		35.3328152593
262PhosphorylationRVKEGSSSQVSQTLN
HHCCCCCCHHHHCCC		35.9825752575
265PhosphorylationEGSSSQVSQTLNIPI
CCCCCHHHHCCCCCE		15.1523749301
267PhosphorylationSSSQVSQTLNIPIKL
CCCHHHHCCCCCEEE		17.7927214570
355AcetylationEHRLYSAKLLANREK
HHHHHHHHHHHHHHH		37.7924489116
451PhosphorylationRNELKDRSGSGTPFF
HHHHHCCCCCCCCCC		47.6627214570
453PhosphorylationELKDRSGSGTPFFET
HHHCCCCCCCCCCCC		40.5127214570
455PhosphorylationKDRSGSGTPFFETSL
HCCCCCCCCCCCCCC		20.7227214570
599PhosphorylationLISSTTKSPQHTLSQ
HHHCCCCCCCCCCCC		27.9225752575
605PhosphorylationKSPQHTLSQRDFGVI
CCCCCCCCCCCEEEE		25.0720190278
629PhosphorylationRSSRRPQSTLEPSTK
CCCCCCCCCCCCCCC		37.3323749301
711PhosphorylationLAKKRELTESVSPPV
HHHHHHCHHCCCCCC		22.8224961812
713PhosphorylationKKRELTESVSPPVFN
HHHHCHHCCCCCCCC		23.7424961812
715PhosphorylationRELTESVSPPVFNNA
HHCHHCCCCCCCCCC		32.5325521595
737PhosphorylationTTPSIAAYEKTNPAI
CCCCCHHHHCCCCCC		14.6728132839
760PhosphorylationAHPIITYSQQTGSKT
CCCEEEEECCCCCCC		13.7320190278
765PhosphorylationTYSQQTGSKTVPQAP
EEECCCCCCCCCCCC		28.6527017623
778PhosphorylationAPQAPQTSQASIQPQ
CCCCCCCCCCCCCHH		20.6423749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of IOC2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of IOC2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of IOC2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DBF4_YEASTDBF4genetic
17314980
NUP84_YEASTNUP84genetic
17314980
BUB1_YEASTBUB1genetic
17314980
VPS64_YEASTVPS64genetic
17314980
PAT1_YEASTPAT1genetic
17314980
CHD1_YEASTCHD1genetic
17314980
PFD3_YEASTPAC10genetic
17314980
NU133_YEASTNUP133genetic
17314980
RPA34_YEASTRPA34genetic
17314980
SLX8_YEASTSLX8genetic
17314980
IOC4_YEASTIOC4physical
27768892
ISW1_YEASTISW1physical
27768892
SHE1_YEASTSHE1genetic
27708008
PFF1_YEASTPFF1genetic
27708008
VAM6_YEASTVAM6genetic
27708008
RPA34_YEASTRPA34genetic
27708008
RAD10_YEASTRAD10genetic
27708008
VAM3_YEASTVAM3genetic
27708008
YA065_YEASTYAL065Cgenetic
27708008
AP2A_YEASTAPL3genetic
27708008
TCM62_YEASTTCM62genetic
27708008
SIF2_YEASTSIF2genetic
27708008
ARL1_YEASTARL1genetic
27708008
SDS24_YEASTSDS24genetic
27708008
POF1_YEASTPOF1genetic
27708008
CSM1_YEASTCSM1genetic
27708008
PCL2_YEASTPCL2genetic
27708008
ARO1_YEASTARO1genetic
27708008
WDR59_YEASTMTC5genetic
27708008
ACL4_YEASTYDR161Wgenetic
27708008
UME6_YEASTUME6genetic
27708008
CHD1_YEASTCHD1genetic
27708008
TBP7_YEASTYTA7genetic
27708008
GOSR1_YEASTGOS1genetic
27708008
YJF5_YEASTYJL055Wgenetic
27708008
GLG2_YEASTGLG2genetic
27708008
ELM1_YEASTELM1genetic
27708008
FRMSR_YEASTYKL069Wgenetic
27708008
SRX1_YEASTSRX1genetic
27708008
NKP2_YEASTNKP2genetic
27708008
ELP1_YEASTIKI3genetic
27708008
SRC1_YEASTSRC1genetic
27708008
VPS9_YEASTVPS9genetic
27708008
MTHR1_YEASTMET12genetic
27708008
MED1_YEASTMED1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of IOC2_YEAST

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-260; SER-261; SER-262;SER-451; THR-455 AND SER-599, AND MASS SPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory