SRC1_YEAST - dbPTM
SRC1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SRC1_YEAST
UniProt AC Q03707
Protein Name Inner nuclear membrane protein SRC1
Gene Name SRC1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 834
Subcellular Localization Nucleus inner membrane
Multi-pass membrane protein . Targeting to the inner nuclear membrane requires the SRP1 and KAP95 karyopherins and the Ran cycle.
Protein Description Plays a role in sister chromatid separation..
Protein Sequence MNSDLEYLEDGFDPNSMKVATLRRILVENNVDFPSNARKNALVGLFDEKVKPQIPQLRKMYLNVRPSDEGIVKMDRPSSSPSIASPRRSRRARREKSASPMAKQFKKNRILDDVSNDDDDDDDDDDDNDKKDDPLIVPSGTDTDEVDDEEDDVITSSSNKSDTNDFQQNSDTRKKRKDPDSDDWSESNSKENKIDNKHLNLLSSDSEIEQDYQKAKKRKTSDLNQEHGNGSAILGKLSVKTPIKNTNRKPVSMDNFNDSLTSSGTENDPFVPNIRHNPKELGTANGTGHSTPLSKLKVSASFADKLPQKEVPSTILVPEVEQQEPSQSERTPSLFSSEGSGSESEAPLLPEITTPGPHQPMGNTSNNVVEMIDTDSSNLVSDEDEVLVPTRIETPQLPTEKDVEKCEARVQELQEEVNEQLEHENGSEFDVKQGSGKVGNRHKFKRALKFLSKSLLALFLFCIFIVIPLLFGLWYREQRLLIGYCGHEVPSHRVSGNSFEFIQKLDNLLQDYRPKCIPCPPNGICYPYLKLKCKPDYKLAPSRLDFLEIIPAQGKCVKDDKKQQLVSEVVEKSLEFLRAKNAQISCGDGKDDIESGMTEDALYQIFNEARAPWIRDDEFEDLWIQVIKDLTEEPEILWRQLSPTDNNIGGNSNNIIKTNDVPRQKRHLPEKFISKTRNFRSTSKKYIGMKCRFEREIYQTYKKFQRPIWLMFLLIVISKVIEIKLKNYYRKKARIEELVTQTMEKLKFQKIKSMSDPKENAYLSIVQLRDIFLSDIVDLKYKNQLWSEVVKYLEHNNSNIKSNLTEIRGEIMKCWEWIGPMELNEPKDSAENKI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MNSDLEYLED
-----CCCHHHHHHC		42.1228152593
7Phosphorylation-MNSDLEYLEDGFDP
-CCCHHHHHHCCCCC		23.7619823750
16PhosphorylationEDGFDPNSMKVATLR
HCCCCCCCCHHHHHH		25.9319823750
67PhosphorylationMYLNVRPSDEGIVKM
HHHCCCCCCCCCCCC		37.4221440633
73AcetylationPSDEGIVKMDRPSSS
CCCCCCCCCCCCCCC		32.9125381059
78PhosphorylationIVKMDRPSSSPSIAS
CCCCCCCCCCCCCCC		44.3222369663
79PhosphorylationVKMDRPSSSPSIASP
CCCCCCCCCCCCCCH		49.2922369663
80PhosphorylationKMDRPSSSPSIASPR
CCCCCCCCCCCCCHH		27.3122369663
82PhosphorylationDRPSSSPSIASPRRS
CCCCCCCCCCCHHHH		32.5022369663
85PhosphorylationSSSPSIASPRRSRRA
CCCCCCCCHHHHHHH		19.7822369663
97PhosphorylationRRARREKSASPMAKQ
HHHHHHHCCCHHHHH		29.2619684113
99PhosphorylationARREKSASPMAKQFK
HHHHHCCCHHHHHHH		23.4625752575
115PhosphorylationNRILDDVSNDDDDDD
CCCCCCCCCCCCCCC		41.3519795423
141PhosphorylationPLIVPSGTDTDEVDD
CEEECCCCCCCCCCC		39.8128889911
161PhosphorylationITSSSNKSDTNDFQQ
EECCCCCCCCCCCCC		54.6522369663
163PhosphorylationSSSNKSDTNDFQQNS
CCCCCCCCCCCCCCC		43.7222369663
181PhosphorylationKKRKDPDSDDWSESN
HHHCCCCCCCCHHHH		42.7425521595
185PhosphorylationDPDSDDWSESNSKEN
CCCCCCCHHHHHHHH		37.8325521595
187PhosphorylationDSDDWSESNSKENKI
CCCCCHHHHHHHHCC		40.6729136822
189PhosphorylationDDWSESNSKENKIDN
CCCHHHHHHHHCCCH		51.1029136822
203PhosphorylationNKHLNLLSSDSEIEQ
HHHHHHHCCCHHHHH		34.9522369663
204PhosphorylationKHLNLLSSDSEIEQD
HHHHHHCCCHHHHHH		45.1622369663
206PhosphorylationLNLLSSDSEIEQDYQ
HHHHCCCHHHHHHHH		42.2822369663
212PhosphorylationDSEIEQDYQKAKKRK
CHHHHHHHHHHHHHC		16.1722890988
220PhosphorylationQKAKKRKTSDLNQEH
HHHHHHCCCCCCHHH		31.3520377248
221PhosphorylationKAKKRKTSDLNQEHG
HHHHHCCCCCCHHHC		43.0417287358
231PhosphorylationNQEHGNGSAILGKLS
CHHHCCCCCHHHEEE		19.0128152593
236AcetylationNGSAILGKLSVKTPI
CCCCHHHEEEECCCC		33.8624489116
240AcetylationILGKLSVKTPIKNTN
HHHEEEECCCCCCCC		45.2525381059
241PhosphorylationLGKLSVKTPIKNTNR
HHEEEECCCCCCCCC		28.2621551504
252PhosphorylationNTNRKPVSMDNFNDS
CCCCCCCCHHCCCHH		29.0119779198
259PhosphorylationSMDNFNDSLTSSGTE
CHHCCCHHCCCCCCC		34.3519779198
261PhosphorylationDNFNDSLTSSGTEND
HCCCHHCCCCCCCCC		25.4619779198
262PhosphorylationNFNDSLTSSGTENDP
CCCHHCCCCCCCCCC		31.8723749301
263PhosphorylationFNDSLTSSGTENDPF
CCHHCCCCCCCCCCC		44.4923749301
265PhosphorylationDSLTSSGTENDPFVP
HHCCCCCCCCCCCCC		33.3023749301
283PhosphorylationHNPKELGTANGTGHS
CCHHHHCCCCCCCCC		29.5822369663
287PhosphorylationELGTANGTGHSTPLS
HHCCCCCCCCCCCHH		31.3722369663
290PhosphorylationTANGTGHSTPLSKLK
CCCCCCCCCCHHHCE		32.8222369663
291PhosphorylationANGTGHSTPLSKLKV
CCCCCCCCCHHHCEE		23.6822369663
294PhosphorylationTGHSTPLSKLKVSAS
CCCCCCHHHCEEEHH		36.8322369663
295AcetylationGHSTPLSKLKVSASF
CCCCCHHHCEEEHHH		61.0724489116
299PhosphorylationPLSKLKVSASFADKL
CHHHCEEEHHHHHCC		19.3322369663
301PhosphorylationSKLKVSASFADKLPQ
HHCEEEHHHHHCCCC		17.2922369663
305AcetylationVSASFADKLPQKEVP
EEHHHHHCCCCCCCC		59.6524489116
326PhosphorylationEVEQQEPSQSERTPS
CHHHCCCCCCCCCCH		45.6528889911
328PhosphorylationEQQEPSQSERTPSLF
HHCCCCCCCCCCHHH		33.1228132839
394PhosphorylationLVPTRIETPQLPTEK
EECCCCCCCCCCCHH		17.6022369663
399PhosphorylationIETPQLPTEKDVEKC
CCCCCCCCHHHHHHH		65.3522890988
405UbiquitinationPTEKDVEKCEARVQE
CCHHHHHHHHHHHHH		36.9023749301
427PhosphorylationQLEHENGSEFDVKQG
HHHHCCCCCCEECCC		46.8223749301
432UbiquitinationNGSEFDVKQGSGKVG
CCCCCEECCCCCCCC		51.2723749301
491PhosphorylationYCGHEVPSHRVSGNS
ECCCCCCCCCCCCCH		29.1525005228
682PhosphorylationKTRNFRSTSKKYIGM
HCCCCCCCCHHHCCC		40.0728889911
683PhosphorylationTRNFRSTSKKYIGMK
CCCCCCCCHHHCCCE		28.5328889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SRC1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SRC1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SRC1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MLC1_YEASTMLC1physical
16554755
SWR1_YEASTSWR1genetic
17314980
THP2_YEASTTHP2genetic
17314980
UBC4_YEASTUBC4genetic
17314980
SEM1_YEASTSEM1genetic
17314980
SWC3_YEASTSWC3genetic
17314980
VPS72_YEASTVPS72genetic
17314980
SWC5_YEASTSWC5genetic
17314980
SAC1_YEASTSAC1genetic
17314980
RPN10_YEASTRPN10genetic
17314980
DOA1_YEASTDOA1genetic
17314980
RPN4_YEASTRPN4genetic
17314980
VID22_YEASTVID22genetic
17314980
UBP6_YEASTUBP6genetic
17314980
SAC3_YEASTSAC3genetic
17314980
SEC66_YEASTSEC66genetic
17314980
NU133_YEASTNUP133genetic
17314980
PAT1_YEASTPAT1genetic
17314980
ARP6_YEASTARP6genetic
17314980
EAF5_YEASTEAF5genetic
17314980
SWD3_YEASTSWD3genetic
17314980
LSM6_YEASTLSM6genetic
17314980
NUP60_YEASTNUP60genetic
17314980
IOC2_YEASTIOC2genetic
17314980
ESC2_YEASTESC2genetic
17314980
RPN6_YEASTRPN6genetic
17314980
MET18_YEASTMET18genetic
17314980
BUD27_YEASTBUD27genetic
17314980
HCM1_YEASTHCM1genetic
17314980
RPA34_YEASTRPA34genetic
17314980
XRN1_YEASTXRN1genetic
17314980
APQ12_YEASTAPQ12genetic
17314980
TBP7_YEASTYTA7genetic
17314980
CYP7_YEASTCPR7genetic
17314980
SWM1_YEASTSWM1genetic
17314980
PSA3_YEASTPRE9genetic
17314980
RAD23_YEASTRAD23genetic
17314980
RPN13_YEASTRPN13genetic
17314980
IST3_YEASTIST3genetic
17314980
GCN1_YEASTGCN1genetic
17314980
SUS1_YEASTSUS1genetic
17314980
REI1_YEASTREI1genetic
17314980
GET1_YEASTGET1genetic
17314980
SLD5_YEASTSLD5physical
11283351
SCC1_YEASTMCD1genetic
11754482
ESP1_YEASTESP1genetic
11754482
PAT1_YEASTPAT1genetic
19061648
UBP6_YEASTUBP6genetic
19061648
TAD3_YEASTTAD3genetic
19061648
LSM3_YEASTLSM3genetic
19061648
RPN4_YEASTRPN4genetic
19061648
SAC3_YEASTSAC3genetic
19061648
SWR1_YEASTSWR1genetic
19061648
SEM1_YEASTSEM1genetic
19061648
TRM7_YEASTTRM7genetic
19061648
SWD3_YEASTSWD3genetic
19061648
TFS2_YEASTDST1genetic
19061648
PSA3_YEASTPRE9genetic
19061648
IF4F1_YEASTTIF4631genetic
19061648
LSM1_YEASTLSM1genetic
19061648
IF2A_YEASTSUI2genetic
19061648
DOA1_YEASTDOA1genetic
19061648
LTV1_YEASTLTV1genetic
19061648
THP1_YEASTTHP1genetic
19061648
H2AZ_YEASTHTZ1genetic
19061648
RRP6_YEASTRRP6genetic
19061648
LSM7_YEASTLSM7genetic
19061648
EAF7_YEASTEAF7genetic
19061648
SN309_YEASTSNT309genetic
19061648
THP2_YEASTTHP2genetic
19061648
RPN10_YEASTRPN10genetic
19061648
EAF5_YEASTEAF5genetic
19061648
NUR1_YEASTNUR1physical
18997772
LRS4_YEASTLRS4physical
18997772
CSM1_YEASTCSM1physical
18997772
H2B1_YEASTHTB1physical
18997772
H2B2_YEASTHTB2physical
18997772
SIR2_YEASTSIR2genetic
18997772
NUR1_YEASTNUR1genetic
18997772
ERV46_YEASTERV46genetic
20093466
DEP1_YEASTDEP1genetic
20093466
SWC3_YEASTSWC3genetic
20093466
NUP60_YEASTNUP60genetic
20093466
AVT5_YEASTAVT5genetic
20093466
UGA2_YEASTUGA2genetic
20093466
UBP14_YEASTUBP14genetic
20093466
UBC4_YEASTUBC4genetic
20093466
SIF2_YEASTSIF2genetic
20093466
SEC66_YEASTSEC66genetic
20093466
SWC5_YEASTSWC5genetic
20093466
PAT1_YEASTPAT1genetic
20093466
PDP2_YEASTPTC6genetic
20093466
YD186_YEASTYDL186Wgenetic
20093466
RPN4_YEASTRPN4genetic
20093466
INO2_YEASTINO2genetic
20093466
ARO1_YEASTARO1genetic
20093466
SAC3_YEASTSAC3genetic
20093466
SSD1_YEASTSSD1genetic
20093466
SWR1_YEASTSWR1genetic
20093466
EAF1_YEASTEAF1genetic
20093466
SEM1_YEASTSEM1genetic
20093466
VPS72_YEASTVPS72genetic
20093466
SC6B1_YEASTSBH1genetic
20093466
BMH1_YEASTBMH1genetic
20093466
UBP6_YEASTUBP6genetic
20093466
THP2_YEASTTHP2genetic
20093466
ICE2_YEASTICE2genetic
20093466
SYG1_YEASTSYG1genetic
20093466
APQ12_YEASTAPQ12genetic
20093466
LSM1_YEASTLSM1genetic
20093466
DPH4_YEASTJJJ3genetic
20093466
DOA1_YEASTDOA1genetic
20093466
SAC1_YEASTSAC1genetic
20093466
YET1_YEASTYET1genetic
20093466
NU133_YEASTNUP133genetic
20093466
MLP1_YEASTMLP1genetic
20093466
POM34_YEASTPOM34genetic
20093466
XYL2_YEASTXYL2genetic
20093466
ARP6_YEASTARP6genetic
20093466
IOC2_YEASTIOC2genetic
20093466
DPH5_YEASTDPH5genetic
20093466
PFD6_YEASTYKE2genetic
20093466
SEC72_YEASTSEC72genetic
20093466
VRP1_YEASTVRP1genetic
20093466
VID22_YEASTVID22genetic
20093466
PO152_YEASTPOM152genetic
20093466
LSM7_YEASTLSM7genetic
20093466
WDR6_YEASTRTT10genetic
20093466
YME1_YEASTYME1genetic
20093466
KAR3_YEASTKAR3genetic
20093466
SRS2_YEASTSRS2genetic
21459050
SIR4_YEASTSIR4physical
21664583
MPS3_YEASTMPS3genetic
21664583
ESC1_YEASTESC1genetic
21664583
PO152_YEASTPOM152physical
21346187
NU170_YEASTNUP170physical
21346187
PO152_YEASTPOM152genetic
21346187
POM34_YEASTPOM34genetic
21346187
NDC1_YEASTNDC1genetic
21346187
NU157_YEASTNUP157genetic
21346187
NUP53_YEASTNUP53genetic
21346187
NUP59_YEASTASM4genetic
21346187
NUP60_YEASTNUP60genetic
21346187
MLP1_YEASTMLP1genetic
21346187
APQ12_YEASTAPQ12genetic
21346187
RTN1_YEASTRTN1genetic
21346187
HEH2_YEASTHEH2genetic
21346187
MPS3_YEASTMPS3genetic
22876257
SWC3_YEASTSWC3genetic
27708008
ERV46_YEASTERV46genetic
27708008
AVT5_YEASTAVT5genetic
27708008
UBC4_YEASTUBC4genetic
27708008
SEC66_YEASTSEC66genetic
27708008
SWC5_YEASTSWC5genetic
27708008
SSH1_YEASTSSH1genetic
27708008
PAT1_YEASTPAT1genetic
27708008
PDP2_YEASTPTC6genetic
27708008
RPN4_YEASTRPN4genetic
27708008
SAC3_YEASTSAC3genetic
27708008
SWR1_YEASTSWR1genetic
27708008
SEM1_YEASTSEM1genetic
27708008
VPS72_YEASTVPS72genetic
27708008
SCS2_YEASTSCS2genetic
27708008
UBP6_YEASTUBP6genetic
27708008
DBF2_YEASTDBF2genetic
27708008
THP2_YEASTTHP2genetic
27708008
RPN10_YEASTRPN10genetic
27708008
ICE2_YEASTICE2genetic
27708008
LSM1_YEASTLSM1genetic
27708008
YET1_YEASTYET1genetic
27708008
FRMSR_YEASTYKL069Wgenetic
27708008
CTK1_YEASTCTK1genetic
27708008
DOA1_YEASTDOA1genetic
27708008
POM34_YEASTPOM34genetic
27708008
IOC2_YEASTIOC2genetic
27708008
SEC72_YEASTSEC72genetic
27708008
PO152_YEASTPOM152genetic
27708008
EAF7_YEASTEAF7genetic
27708008
YNO0_YEASTYNL140Cgenetic
27708008
LSM7_YEASTLSM7genetic
27708008
VPS27_YEASTVPS27genetic
27708008
SEY1_YEASTSEY1genetic
27708008
WDR6_YEASTRTT10genetic
27708008
YME1_YEASTYME1genetic
27708008
KAR3_YEASTKAR3genetic
27708008
YJE9_YEASTYJL049Wphysical
27733427
SNF7_YEASTSNF7physical
27733427
LRS4_YEASTLRS4physical
25073155
LRS4_YEASTLRS4physical
26205667
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SRC1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-79; SER-80; SER-82;SER-203; SER-204; THR-241; SER-263; SER-301; THR-394 AND SER-427, ANDMASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-79; SER-80; SER-85;SER-203; SER-204; SER-206; SER-299 AND SER-301, AND MASS SPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-221, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-80; SER-85; SER-204 ANDSER-206, AND MASS SPECTROMETRY.

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