| UniProt ID | UBP14_YEAST | |
|---|---|---|
| UniProt AC | P38237 | |
| Protein Name | Ubiquitin carboxyl-terminal hydrolase 14 | |
| Gene Name | UBP14 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 781 | |
| Subcellular Localization | Cytoplasm . Nucleus . | |
| Protein Description | Has a role in the negative regulation of gluconeogenesis. Required for proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase). Accelerates proteasomal breakdown of ubiquitinated proteins as it disassembles free ubiquitin chains that would compete with ubiquitinated proteins to bind to the proteasome.. | |
| Protein Sequence | MAEAVLENVNVPAVVSKDECIYCFESPYNEPLALNASPKHSLNICLNCFQATCNRHVPLHIRVTEYACDTIHSNYLTIAKVEKPKQENVEENNNNKKIKLQVIETSEDDTHNTIWSLQRFNGENVPRTVLSKSTDSDISSTALEKIEKILKAKSQDFEDKKNSWVLEISTCPHTENFQIPSKPENTVNLNQCSSCDLTQNLWLCLHCGNIGCGREQIGIDGHSHALDHYRSNNNHPLAIKLGSLSSSTYDLYCYACDDETRFPDNVNLGSALQIYGINIQEKIADEKTLVQLQVEQNENWQFRMVDSSGKEFEKLSASKNYGCGLINLGNSCYLNSVIQSLVNGGVPNWSLDFLGSKFPLDVVYPDNNLKCQWIKLLNAMKCEPELYPNGIKPTTFKKCIGQNHQEFSSNRQQDAMEFLTFLLDLLDKKFFSSSSSGIPNPNDLVRFMMEDRLQCNICGKVKYSYEPTEAIQIPLEENDEPQDMLERIKAYFEGQTIEFKCANCKEKVTANKKPGFKSLPQTLILNPIRIRLQNWIPVKTSNELSLPGLIDRDDMLDVSSYLSQGFDPQTENLLPDEDENRSSFTPNQCSISQLIEMGFTQNASVRALFNTGNQDAESAMNWLFQHMDDPDLNDPFVPPPNVPKKDKREVDEVSLTSMLSMGLNPNLCRKALILNNGDVNRSVEWVFNNMDDDGTFPEPEVPNEEQQQKKDLGYSTAKPYALTAVICHKGNSVHSGHYVVFIRKLVADKWKWVLYNDEKLVAADSIEDMKKNGYIYFYTRC | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 37 | Phosphorylation | EPLALNASPKHSLNI CCCCCCCCCCCHHHH | 33.15 | 27017623 | |
| 39 | Ubiquitination | LALNASPKHSLNICL CCCCCCCCCHHHHHH | 43.24 | 17644757 | |
| 99 | Ubiquitination | NNNNKKIKLQVIETS CCCCCEEEEEEEECC | 41.57 | 17644757 | |
| 105 | Phosphorylation | IKLQVIETSEDDTHN EEEEEEECCCCCCCC | 26.71 | 22369663 | |
| 106 | Phosphorylation | KLQVIETSEDDTHNT EEEEEECCCCCCCCC | 26.66 | 22369663 | |
| 110 | Phosphorylation | IETSEDDTHNTIWSL EECCCCCCCCCEEEE | 29.37 | 22369663 | |
| 113 | Phosphorylation | SEDDTHNTIWSLQRF CCCCCCCCEEEEEEC | 19.07 | 22369663 | |
| 132 | Ubiquitination | VPRTVLSKSTDSDIS CCCEEEECCCCCCCC | 53.89 | 23749301 | |
| 145 | Ubiquitination | ISSTALEKIEKILKA CCHHHHHHHHHHHHH | 57.95 | 17644757 | |
| 148 | Ubiquitination | TALEKIEKILKAKSQ HHHHHHHHHHHHHCC | 57.73 | 17644757 | |
| 240 | Ubiquitination | NNHPLAIKLGSLSSS CCCCEEEEECCCCCC | 40.98 | 17644757 | |
| 287 | Ubiquitination | QEKIADEKTLVQLQV HHHHCCCCEEEEEEE | 47.94 | 17644757 | |
| 314 | Acetylation | SSGKEFEKLSASKNY CCCCCEEHHHCCCCC | 53.73 | 24489116 | |
| 357 | Ubiquitination | SLDFLGSKFPLDVVY EEECCCCCCCCCEEC | 49.56 | 17644757 | |
| 370 | Ubiquitination | VYPDNNLKCQWIKLL ECCCCCCCHHHHHHH | 26.89 | 23749301 | |
| 397 | Ubiquitination | GIKPTTFKKCIGQNH CCCCCHHHHHHCCCH | 44.64 | 22817900 | |
| 398 | Ubiquitination | IKPTTFKKCIGQNHQ CCCCHHHHHHCCCHH | 27.22 | 23749301 | |
| 428 | Ubiquitination | FLLDLLDKKFFSSSS HHHHHHCHHHHCCCC | 51.99 | 17644757 | |
| 429 | Ubiquitination | LLDLLDKKFFSSSSS HHHHHCHHHHCCCCC | 51.84 | 24961812 | |
| 436 | Phosphorylation | KFFSSSSSGIPNPND HHHCCCCCCCCCHHH | 42.56 | 25752575 | |
| 489 | Ubiquitination | QDMLERIKAYFEGQT HHHHHHHHHHHCCCE | 43.16 | 15699485 | |
| 500 | Ubiquitination | EGQTIEFKCANCKEK CCCEEEEEECCCCCC | 21.46 | 23749301 | |
| 505 | Ubiquitination | EFKCANCKEKVTANK EEEECCCCCCCCCCC | 61.45 | 22817900 | |
| 517 | Ubiquitination | ANKKPGFKSLPQTLI CCCCCCCCCCCCEEE | 57.93 | 17644757 | |
| 670 | Ubiquitination | LNPNLCRKALILNNG CCHHHCCEEEEECCC | 46.69 | 23749301 | |
| 759 | Ubiquitination | WVLYNDEKLVAADSI EEEECCCCEEEECCH | 51.64 | 15699485 | |
| 770 | Ubiquitination | ADSIEDMKKNGYIYF ECCHHHHHHCCEEEE | 56.24 | 23749301 | |
| 771 | Ubiquitination | DSIEDMKKNGYIYFY CCHHHHHHCCEEEEE | 49.30 | 15699485 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of UBP14_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of UBP14_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of UBP14_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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