| UniProt ID | CTF4_YEAST | |
|---|---|---|
| UniProt AC | Q01454 | |
| Protein Name | DNA polymerase alpha-binding protein | |
| Gene Name | CTF4 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 927 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Accessory factor for DNA replication. It plays a role in accurately duplicating the genome in vivo.. | |
| Protein Sequence | MVSVIDKLVFDFGGKTLVSLAPDNNTLCVANKNGLTKILKTNNPEEEPETLDSSKLVSSIKCYSNSHFLMTTMQGDALRYNIDSSQEELLARFALPLRDCCVIHSGKMAVFGGDDLELILLELDDETHKKHAIKIDEQVSQISYNSQMNILAVSMINGKVQIFSLTSTIPNKVHELNDYIVANSYDDTHRDKILSNMMDDIDKDNDNDLSETADPDENNVADPEFCAANRICTRVAWHPKGLHFALPCADDTVKIFSIKGYSLQKTLSTNLSSTKAHFIDLQFDPLRGTYIAAVDLNNKLTVWNWETSEIHYTREFKRKITNIAWKIQADSKTLDLVLGTWSGSIAIVQNLAESVVSNIPDQSVAESSTKHGLFVDSESDLENLEGNDDINKSDKLFSDITQEANAEDVFTQTHDGPSGLSEKRKYNFEDEEDFIDDDDGAGYISGKKPHNEHSYSRVHKTHSFPISLANTGKFRYMPFSPAGTPFGFTDRRYLTMNEVGYVSTVKNSEQYSITVSFFDVGRFREYHFEDLFGYDLCFLNEKGTLFGQSKTGQIQYRPHDSIHSNWTKIIPLQAGERITSVAATPVRVIVGTSLGYFRSFNQFGVPFAVEKTSPIVALTAQNYRVFSVHYSQFHGLSYSLSELGTSSKRYYKRECPLPMSLPNINSDMKKDANLDYYNFNPMGIKSLFFSSYGDPCIFGSDNTLLLLSKWRSPEESKWLPILDSNMEIWKMSGGKETTDIHVWPLALAYDTLNCILVKGKHIWPEFPLPLPSEMEIRMPVFVKSKLLEENKAILNKKNEIGADTEAEEGEEDKEIQIPVSMAAEEEYLRSKVLSELLTDTLENDGEMYGNENEVLAALNGAYDKALLRLFASACSDQNVEKALSLAHELKQDRALTAAVKISERAELPSLVKKINNIREARYEQQLK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 40 | Ubiquitination | NGLTKILKTNNPEEE CCCEEEECCCCCCCC | 53.32 | 23749301 | |
| 80 | Phosphorylation | MQGDALRYNIDSSQE ECCCCEEECCCCCHH | 19.81 | 25533186 | |
| 212 | Phosphorylation | NDNDLSETADPDENN CCCCHHHCCCCCCCC | 32.74 | 27738172 | |
| 377 | Phosphorylation | KHGLFVDSESDLENL CCEEEECCHHHHHHC | 33.43 | 22369663 | |
| 379 | Phosphorylation | GLFVDSESDLENLEG EEEECCHHHHHHCCC | 51.99 | 22369663 | |
| 393 | Phosphorylation | GNDDINKSDKLFSDI CCCCCCHHHHHHHHH | 35.17 | 19795423 | |
| 398 | Phosphorylation | NKSDKLFSDITQEAN CHHHHHHHHHHHHCC | 38.24 | 22369663 | |
| 401 | Phosphorylation | DKLFSDITQEANAED HHHHHHHHHHCCHHH | 25.91 | 22369663 | |
| 411 | Phosphorylation | ANAEDVFTQTHDGPS CCHHHCCCCCCCCCC | 32.19 | 22369663 | |
| 413 | Phosphorylation | AEDVFTQTHDGPSGL HHHCCCCCCCCCCCC | 20.90 | 20377248 | |
| 418 | Phosphorylation | TQTHDGPSGLSEKRK CCCCCCCCCCCCCCC | 58.87 | 22369663 | |
| 421 | Phosphorylation | HDGPSGLSEKRKYNF CCCCCCCCCCCCCCC | 44.59 | 22369663 | |
| 445 | Phosphorylation | DDGAGYISGKKPHNE CCCCCCCCCCCCCCC | 35.76 | 21551504 | |
| 447 | Acetylation | GAGYISGKKPHNEHS CCCCCCCCCCCCCCC | 57.23 | 24489116 | |
| 448 | Acetylation | AGYISGKKPHNEHSY CCCCCCCCCCCCCCC | 55.84 | 25381059 | |
| 456 | Phosphorylation | PHNEHSYSRVHKTHS CCCCCCCCCCCCCCC | 30.73 | 30377154 | |
| 463 | Phosphorylation | SRVHKTHSFPISLAN CCCCCCCCCEEEECC | 37.64 | 17563356 | |
| 467 | Phosphorylation | KTHSFPISLANTGKF CCCCCEEEECCCCCE | 22.97 | 27017623 | |
| 471 | Phosphorylation | FPISLANTGKFRYMP CEEEECCCCCEEEEE | 35.82 | 27017623 | |
| 473 | Acetylation | ISLANTGKFRYMPFS EEECCCCCEEEEECC | 25.32 | 24489116 | |
| 511 | Phosphorylation | TVKNSEQYSITVSFF EECCCCEEEEEEEEE | 9.66 | 28132839 | |
| 584 | Phosphorylation | RITSVAATPVRVIVG CEEECCCCEEEEEEE | 16.75 | 27214570 | |
| 670 | Acetylation | NINSDMKKDANLDYY CCCCCCCCCCCCCCC | 56.27 | 24489116 | |
| 804 | Phosphorylation | KNEIGADTEAEEGEE CCCCCCCCCCCCCCC | 36.24 | 21440633 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CTF4_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CTF4_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CTF4_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-377; SER-379; THR-401;THR-411 AND SER-463, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-377; SER-379 ANDSER-463, AND MASS SPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-377 AND SER-379, ANDMASS SPECTROMETRY. | |
