| UniProt ID | RT107_YEAST | |
|---|---|---|
| UniProt AC | P38850 | |
| Protein Name | Regulator of Ty1 transposition protein 107 | |
| Gene Name | RTT107 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1070 | |
| Subcellular Localization | Nucleus . Recruited to chromatin in response to replication fork stalling. | |
| Protein Description | Required for resumption of chromosome replication after DNA damage, specifically in S phase. Is recruited to chromatin in the presence of RTT109 and RTT101 in response to stalled replication forks and acts as a scaffold during DNA repair.. | |
| Protein Sequence | MSTSLLFEQLNFLILVAAEAELPIAHSTRKLLMDNSCNNCQIYELYNENLKDVKTDKDWFMNKFGPQTVHFVISNTINFPFYKIVYFDLLIPVVSHTWVQDSVKTKRHLRTNMYSPNPFHLLRDCQVYISKSSFNKCEYILYSDLLHLLGGTLVNYISNRTTHVIVQSPQDPIIATVSKLTFGSFSSSSTNKHTEKPLREWKFVYPIWILYHFKMAKPLKGELATLCELDMQDTSEEQLFAKWEEVIGDKQTSSSQLTLHPNKTLFKNHHFAISPDLNFFTPLYWFLKGFIEDLDGKVTPLSFSDDLKSVYQAFPDIDCYIGHSANSPILEKTKSIKPEIHVGNVSWLFYMFALQKFTPVSQCKLIHQPFHAKLFTSKELTVAYTNYFGSQRFYIQRLVEILGGLSTPELTRKNTHLITKSTIGKKFKVAKKWSLDPQNAIIVTNHMWLEQCYMNNSKLNPKDSRFQNFKLDDNMGWNIGQIGMDHSSLPTPKNLSMVTYDTQSISEKPPPTNDQMDQINDNTNVLSKKDGTPISSFENSIDEKIDKLQKISGEVAVTHSGDLERSFVSRPSRASFPVVDSKKSNLQKKDSNSDISMETEVFCEGHEKREEKEFTKPITEYDAPKKQEIREQSRKKNDIDYKKEEEETELQVQLGQRTKREIKTSKKNEKEKETNECHIEVDQMTNEKQGEESTGKLISTEDVTSKKDTDKFSHLFEGLSDNDDHINDEKPAVNSKYTTPKTSQNITSGVDTPTTAQTQVFMPSSGNSRLAKTQAAKRLHTDIESLNEFQKNFKRKRIDSEEISLSQDVERSNNNKELATKAEKILARFNELPNYDLKAVCTGCFHDGFNEVDIEILNQLGIKIFDNIKETDKLNCIFAPKILRTEKFLKSLSFEPLKFALKPEFIIDLLKQIHSKKDKLSQININLFDYEINGINESIISKTKLPTKVFERANIRCINLVNDIPGGVDTIGSVLKAHGIEKINVLRSKKCTFEDIIPNDVSKQENGGIFKYVLIVTKASQVKKFTKLINDRDKNETILIVEWNWCVESIFHLNVDFTSKKNVLYQKKNN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 181 | Phosphorylation | IATVSKLTFGSFSSS EEEEEECCCCCCCCC | 29.68 | 29136822 | |
| 184 | Phosphorylation | VSKLTFGSFSSSSTN EEECCCCCCCCCCCC | 20.12 | 20190278 | |
| 186 | Phosphorylation | KLTFGSFSSSSTNKH ECCCCCCCCCCCCCC | 30.89 | 30377154 | |
| 187 | Phosphorylation | LTFGSFSSSSTNKHT CCCCCCCCCCCCCCC | 26.71 | 29136822 | |
| 188 | Phosphorylation | TFGSFSSSSTNKHTE CCCCCCCCCCCCCCC | 39.73 | 29136822 | |
| 189 | Phosphorylation | FGSFSSSSTNKHTEK CCCCCCCCCCCCCCC | 37.64 | 27017623 | |
| 190 | Phosphorylation | GSFSSSSTNKHTEKP CCCCCCCCCCCCCCC | 50.68 | 29136822 | |
| 252 | Phosphorylation | EVIGDKQTSSSQLTL HHHCCCCCCCCCEEE | 36.00 | 30377154 | |
| 253 | Phosphorylation | VIGDKQTSSSQLTLH HHCCCCCCCCCEEEC | 26.04 | 21440633 | |
| 254 | Phosphorylation | IGDKQTSSSQLTLHP HCCCCCCCCCEEECC | 26.03 | 28889911 | |
| 255 | Phosphorylation | GDKQTSSSQLTLHPN CCCCCCCCCEEECCC | 29.04 | 25752575 | |
| 302 | Phosphorylation | DGKVTPLSFSDDLKS CCCEEECCCCHHHHH | 24.73 | 27017623 | |
| 304 | Phosphorylation | KVTPLSFSDDLKSVY CEEECCCCHHHHHHH | 27.17 | 28889911 | |
| 373 | Acetylation | IHQPFHAKLFTSKEL CCCCCCCCCCCCCCE | 35.25 | 24489116 | |
| 487 | Phosphorylation | GQIGMDHSSLPTPKN HHCCCCCCCCCCCCC | 29.34 | 27017623 | |
| 488 | Phosphorylation | QIGMDHSSLPTPKNL HCCCCCCCCCCCCCC | 34.64 | 25752575 | |
| 491 | Phosphorylation | MDHSSLPTPKNLSMV CCCCCCCCCCCCEEE | 52.79 | 27017623 | |
| 527 | Phosphorylation | NDNTNVLSKKDGTPI CCCCCCCCCCCCCCC | 33.12 | 15665377 | |
| 532 | Phosphorylation | VLSKKDGTPISSFEN CCCCCCCCCCHHHCC | 27.81 | 22369663 | |
| 535 | Phosphorylation | KKDGTPISSFENSID CCCCCCCHHHCCHHH | 30.12 | 22369663 | |
| 536 | Phosphorylation | KDGTPISSFENSIDE CCCCCCHHHCCHHHH | 36.98 | 20377248 | |
| 540 | Phosphorylation | PISSFENSIDEKIDK CCHHHCCHHHHHHHH | 24.99 | 20377248 | |
| 552 | Phosphorylation | IDKLQKISGEVAVTH HHHHHHHCCEEEEEE | 35.62 | 27017623 | |
| 558 | Phosphorylation | ISGEVAVTHSGDLER HCCEEEEEECCCCHH | 10.69 | 19779198 | |
| 560 | Phosphorylation | GEVAVTHSGDLERSF CEEEEEECCCCHHHE | 25.33 | 25752575 | |
| 566 | Phosphorylation | HSGDLERSFVSRPSR ECCCCHHHEECCCCC | 22.18 | 27017623 | |
| 575 | Phosphorylation | VSRPSRASFPVVDSK ECCCCCCCCCCCCCC | 29.04 | 25752575 | |
| 591 | Phosphorylation | SNLQKKDSNSDISME CCCCCCCCCCCCCHH | 47.30 | 20377248 | |
| 593 | Phosphorylation | LQKKDSNSDISMETE CCCCCCCCCCCHHEE | 40.03 | 20377248 | |
| 596 | Phosphorylation | KDSNSDISMETEVFC CCCCCCCCHHEEEEC | 18.63 | 20377248 | |
| 599 | Phosphorylation | NSDISMETEVFCEGH CCCCCHHEEEECCCC | 28.89 | 19823750 | |
| 615 | Phosphorylation | KREEKEFTKPITEYD HHCCCCCCCCCCCCC | 36.68 | 21440633 | |
| 664 | Phosphorylation | RTKREIKTSKKNEKE HHHHHHHHCCCCHHH | 51.98 | 27017623 | |
| 693 | Phosphorylation | NEKQGEESTGKLIST CCCCCCCCCCCEEEC | 37.85 | 23749301 | |
| 699 | Phosphorylation | ESTGKLISTEDVTSK CCCCCEEECCCCCCC | 35.86 | 27214570 | |
| 700 | Phosphorylation | STGKLISTEDVTSKK CCCCEEECCCCCCCC | 29.25 | 25752575 | |
| 709 | Phosphorylation | DVTSKKDTDKFSHLF CCCCCCCCHHHHHHH | 50.39 | 29688323 | |
| 713 | Phosphorylation | KKDTDKFSHLFEGLS CCCCHHHHHHHCCCC | 25.64 | 22369663 | |
| 720 | Phosphorylation | SHLFEGLSDNDDHIN HHHHCCCCCCCCCCC | 45.27 | 22369663 | |
| 735 | Phosphorylation | DEKPAVNSKYTTPKT CCCCCCCCCCCCCCC | 22.05 | 28889911 | |
| 737 | Phosphorylation | KPAVNSKYTTPKTSQ CCCCCCCCCCCCCCC | 18.70 | 21551504 | |
| 738 | Phosphorylation | PAVNSKYTTPKTSQN CCCCCCCCCCCCCCC | 40.12 | 19779198 | |
| 739 | Phosphorylation | AVNSKYTTPKTSQNI CCCCCCCCCCCCCCC | 21.50 | 23749301 | |
| 742 | Phosphorylation | SKYTTPKTSQNITSG CCCCCCCCCCCCCCC | 36.43 | 17330950 | |
| 743 | Phosphorylation | KYTTPKTSQNITSGV CCCCCCCCCCCCCCC | 27.62 | 17330950 | |
| 747 | Phosphorylation | PKTSQNITSGVDTPT CCCCCCCCCCCCCCC | 27.29 | 23749301 | |
| 752 | Phosphorylation | NITSGVDTPTTAQTQ CCCCCCCCCCCCEEE | 21.82 | 21551504 | |
| 754 | Phosphorylation | TSGVDTPTTAQTQVF CCCCCCCCCCEEEEE | 36.53 | 21440633 | |
| 755 | Phosphorylation | SGVDTPTTAQTQVFM CCCCCCCCCEEEEEC | 20.26 | 21551504 | |
| 758 | Phosphorylation | DTPTTAQTQVFMPSS CCCCCCEEEEECCCC | 25.00 | 28889911 | |
| 764 | Phosphorylation | QTQVFMPSSGNSRLA EEEEECCCCCCCHHH | 38.81 | 21551504 | |
| 765 | Phosphorylation | TQVFMPSSGNSRLAK EEEECCCCCCCHHHH | 35.80 | 21440633 | |
| 772 | Acetylation | SGNSRLAKTQAAKRL CCCCHHHHHHHHHHH | 45.84 | 25381059 | |
| 773 | Phosphorylation | GNSRLAKTQAAKRLH CCCHHHHHHHHHHHC | 20.17 | 28889911 | |
| 777 | Acetylation | LAKTQAAKRLHTDIE HHHHHHHHHHCCCHH | 59.51 | 25381059 | |
| 781 | Phosphorylation | QAAKRLHTDIESLNE HHHHHHCCCHHHHHH | 43.17 | 30377154 | |
| 785 | Phosphorylation | RLHTDIESLNEFQKN HHCCCHHHHHHHHHH | 36.51 | 27214570 | |
| 791 | Acetylation | ESLNEFQKNFKRKRI HHHHHHHHHHHHCCC | 70.45 | 24489116 | |
| 800 | Phosphorylation | FKRKRIDSEEISLSQ HHHCCCCHHHCCHHH | 34.46 | 20190278 | |
| 804 | Phosphorylation | RIDSEEISLSQDVER CCCHHHCCHHHHHHH | 25.83 | 22369663 | |
| 806 | Phosphorylation | DSEEISLSQDVERSN CHHHCCHHHHHHHHC | 19.97 | 22369663 | |
| 812 | Phosphorylation | LSQDVERSNNNKELA HHHHHHHHCCCHHHH | 30.33 | 19823750 | |
| 941 | Phosphorylation | GINESIISKTKLPTK CCCHHHHCCCCCCCH | 32.38 | 21551504 | |
| 992 | Phosphorylation | VLRSKKCTFEDIIPN ECCCCCCCHHHCCCC | 38.65 | 20377248 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RT107_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RT107_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RT107_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-184; SER-187; SER-188;THR-190; SER-304; THR-532; SER-536; SER-575; SER-591; SER-593;SER-699; THR-742; SER-800; SER-804 AND SER-806, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-532 AND SER-806, ANDMASS SPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-720, AND MASSSPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-532, AND MASSSPECTROMETRY. | |
