| UniProt ID | BUL1_YEAST | |
|---|---|---|
| UniProt AC | P48524 | |
| Protein Name | Ubiquitin ligase-binding protein BUL1 | |
| Gene Name | BUL1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 976 | |
| Subcellular Localization | Cytoplasm . | |
| Protein Description | Component of a RSP5 ubiquitin ligase complex which specifies polyubiquitination and intracellular trafficking of the general amino acid permease GAP1 as well as other permeases such as PMA1. The RSP5-BUL1/2 complex is also necessary for the heat-shock element (HSE)-mediated gene expression, nitrogen starvation GLN3-dependent transcription and pressure-induced differential regulation of the 2 tryptophan permeases TAT1 and TAT2.. | |
| Protein Sequence | MAKDLNDSGFPPKRKPLLRPQRSDFTANSSTTMNVNANTRGRGRQKQEGGKGSSRSPSLHSPKSWIRSASATGILGLRRPELAHSHSHAPSTGTPAGGNRSPLRRSTANATPVETGRSLTDGDINNVVDVLPSFEMYNTLHRHIPQGNVDPDRHDFPPSYQEANNSTATGAAGSSADLSHQSLSTDALGATRSSSTSNLENLIPLRTEHHSIAAHQSTAVDEDSLDIPPILDDLNDTDNIFIDKLYTLPKMSTPIEITIKTTKHAPIPHVKPEEESILKEYTSGDLIHGFITIENKSQANLKFEMFYVTLESYISIIDKVKSKRTIKRFLRMVDLSASWSYSKIALGSGVDFIPADVDYDGSVFGLNNSRVLEPGVKYKKFFIFKLPLQLLDVTCKQEHFSHCLLPPSFGIDKYRNNCKYSGIKVNRVLGCGHLGTKGSPILTNDMSDDNLSINYTIDARIVGKDQKASKLYIMKEREYNLRVIPFGFDANVVGERTTMSQLNDITKLVQERLDALRKIFQRLEKKEPITNRDIHGADLSGTIDDSIESDSQEILQRKLDQLHIKNRNNYLVNYNDLKLGHDLDNGRSGNSGHNTDTSRAWGPFVESELKYKLKNKSNSSSFLNFSHFLNSSSSSMSSSSNAGKNNHDLTGNKERTGLILVKAKIPKQGLPYWAPSLLRKTNVFESKSKHDQENWVRLSELIPEDVKKPLEKLDLQLTCIESDNSLPHDPPEIQSITTELICITAKSDNSIPIKLNSELLMNKEKLTSIKALYDDFHSKICEYETKFNKNFLELNELYNMNRGDRRPKELKFTDFITSQLFNDIESICNLKVSVHNLSNIFKKQVSTLKQHSKHALSEDSISHTGNGSSSSPSSASLTPVTSSSKSSLFLPSGSSSTSLKFTDQIVHKWVRIAPLQYKRDINVNLEFNKDIKETLIPSFESCLCCRFYCVRVMIKFENHLGVAKIDIPISVRQVTK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 23 | Phosphorylation | PLLRPQRSDFTANSS CCCCCCCCCCCCCCC | 31.65 | 22369663 | |
| 26 | Phosphorylation | RPQRSDFTANSSTTM CCCCCCCCCCCCCCE | 29.89 | 22369663 | |
| 29 | Phosphorylation | RSDFTANSSTTMNVN CCCCCCCCCCCEEEC | 26.97 | 22369663 | |
| 30 | Phosphorylation | SDFTANSSTTMNVNA CCCCCCCCCCEEECC | 27.92 | 22369663 | |
| 31 | Phosphorylation | DFTANSSTTMNVNAN CCCCCCCCCEEECCC | 29.86 | 22369663 | |
| 53 | Phosphorylation | KQEGGKGSSRSPSLH CCCCCCCCCCCCCCC | 26.51 | 22369663 | |
| 54 | Phosphorylation | QEGGKGSSRSPSLHS CCCCCCCCCCCCCCC | 45.50 | 22369663 | |
| 56 | Phosphorylation | GGKGSSRSPSLHSPK CCCCCCCCCCCCCCH | 22.31 | 22369663 | |
| 58 | Phosphorylation | KGSSRSPSLHSPKSW CCCCCCCCCCCCHHH | 39.70 | 22369663 | |
| 61 | Phosphorylation | SRSPSLHSPKSWIRS CCCCCCCCCHHHHHH | 39.04 | 22369663 | |
| 68 | Phosphorylation | SPKSWIRSASATGIL CCHHHHHHHCHHCCC | 19.90 | 22890988 | |
| 70 | Phosphorylation | KSWIRSASATGILGL HHHHHHHCHHCCCCC | 27.84 | 22369663 | |
| 72 | Phosphorylation | WIRSASATGILGLRR HHHHHCHHCCCCCCC | 23.43 | 22890988 | |
| 85 | Phosphorylation | RRPELAHSHSHAPST CCHHHCCCCCCCCCC | 22.52 | 28889911 | |
| 87 | Phosphorylation | PELAHSHSHAPSTGT HHHCCCCCCCCCCCC | 25.10 | 23749301 | |
| 91 | Phosphorylation | HSHSHAPSTGTPAGG CCCCCCCCCCCCCCC | 40.01 | 30377154 | |
| 92 | Phosphorylation | SHSHAPSTGTPAGGN CCCCCCCCCCCCCCC | 43.97 | 23749301 | |
| 94 | Phosphorylation | SHAPSTGTPAGGNRS CCCCCCCCCCCCCCC | 15.28 | 23749301 | |
| 101 | Phosphorylation | TPAGGNRSPLRRSTA CCCCCCCCCCCCCCC | 32.08 | 23749301 | |
| 106 | Phosphorylation | NRSPLRRSTANATPV CCCCCCCCCCCCCCC | 25.99 | 22890988 | |
| 107 | Phosphorylation | RSPLRRSTANATPVE CCCCCCCCCCCCCCC | 23.32 | 22369663 | |
| 111 | Phosphorylation | RRSTANATPVETGRS CCCCCCCCCCCCCCC | 27.89 | 22890988 | |
| 115 | Phosphorylation | ANATPVETGRSLTDG CCCCCCCCCCCCCCC | 37.82 | 22890988 | |
| 118 | Phosphorylation | TPVETGRSLTDGDIN CCCCCCCCCCCCCHH | 36.65 | 22369663 | |
| 120 | Phosphorylation | VETGRSLTDGDINNV CCCCCCCCCCCHHHH | 38.90 | 22369663 | |
| 184 | Phosphorylation | DLSHQSLSTDALGAT CCCCCCCCCCCCCCC | 29.50 | 27214570 | |
| 193 | Phosphorylation | DALGATRSSSTSNLE CCCCCCCCCCCCCHH | 25.04 | 22890988 | |
| 194 | Phosphorylation | ALGATRSSSTSNLEN CCCCCCCCCCCCHHH | 34.05 | 22369663 | |
| 195 | Phosphorylation | LGATRSSSTSNLENL CCCCCCCCCCCHHHC | 36.78 | 22369663 | |
| 196 | Phosphorylation | GATRSSSTSNLENLI CCCCCCCCCCHHHCC | 24.47 | 22890988 | |
| 197 | Phosphorylation | ATRSSSTSNLENLIP CCCCCCCCCHHHCCC | 41.17 | 22890988 | |
| 302 | Ubiquitination | NKSQANLKFEMFYVT CCCCCCCEEEEEEEE | 38.80 | 22106047 | |
| 546 | Phosphorylation | LSGTIDDSIESDSQE CCCCCCCCCCCCHHH | 25.22 | 22369663 | |
| 549 | Phosphorylation | TIDDSIESDSQEILQ CCCCCCCCCHHHHHH | 40.67 | 22369663 | |
| 551 | Phosphorylation | DDSIESDSQEILQRK CCCCCCCHHHHHHHH | 38.70 | 22369663 | |
| 558 | Ubiquitination | SQEILQRKLDQLHIK HHHHHHHHHHHHCCC | 43.38 | 23749301 | |
| 578 | Ubiquitination | LVNYNDLKLGHDLDN EEEHHHEECCCCCCC | 56.11 | 23749301 | |
| 617 | Phosphorylation | KYKLKNKSNSSSFLN HHHHCCCCCCCCHHC | 51.87 | 22369663 | |
| 619 | Phosphorylation | KLKNKSNSSSFLNFS HHCCCCCCCCHHCHH | 34.16 | 22369663 | |
| 620 | Phosphorylation | LKNKSNSSSFLNFSH HCCCCCCCCHHCHHH | 29.38 | 22369663 | |
| 621 | Phosphorylation | KNKSNSSSFLNFSHF CCCCCCCCHHCHHHH | 33.31 | 20377248 | |
| 626 | Phosphorylation | SSSFLNFSHFLNSSS CCCHHCHHHHHCCCC | 16.56 | 22369663 | |
| 631 | Phosphorylation | NFSHFLNSSSSSMSS CHHHHHCCCCCCCCC | 33.47 | 22369663 | |
| 632 | Phosphorylation | FSHFLNSSSSSMSSS HHHHHCCCCCCCCCC | 32.92 | 22369663 | |
| 633 | Phosphorylation | SHFLNSSSSSMSSSS HHHHCCCCCCCCCCC | 26.67 | 22369663 | |
| 634 | Phosphorylation | HFLNSSSSSMSSSSN HHHCCCCCCCCCCCC | 31.82 | 22369663 | |
| 635 | Phosphorylation | FLNSSSSSMSSSSNA HHCCCCCCCCCCCCC | 25.32 | 22369663 | |
| 637 | Phosphorylation | NSSSSSMSSSSNAGK CCCCCCCCCCCCCCC | 29.08 | 22369663 | |
| 638 | Phosphorylation | SSSSSMSSSSNAGKN CCCCCCCCCCCCCCC | 29.19 | 22369663 | |
| 639 | Phosphorylation | SSSSMSSSSNAGKNN CCCCCCCCCCCCCCC | 21.95 | 22369663 | |
| 640 | Phosphorylation | SSSMSSSSNAGKNNH CCCCCCCCCCCCCCC | 32.42 | 22369663 | |
| 857 | Phosphorylation | QHSKHALSEDSISHT HHCCCCCCCCCCCCC | 39.89 | 23749301 | |
| 870 | Phosphorylation | HTGNGSSSSPSSASL CCCCCCCCCCCCCCC | 48.22 | 21440633 | |
| 871 | Phosphorylation | TGNGSSSSPSSASLT CCCCCCCCCCCCCCC | 30.65 | 23749301 | |
| 873 | Phosphorylation | NGSSSSPSSASLTPV CCCCCCCCCCCCCCC | 40.25 | 21440633 | |
| 874 | Phosphorylation | GSSSSPSSASLTPVT CCCCCCCCCCCCCCC | 25.84 | 21440633 | |
| 876 | Phosphorylation | SSSPSSASLTPVTSS CCCCCCCCCCCCCCC | 34.42 | 24961812 | |
| 878 | Phosphorylation | SPSSASLTPVTSSSK CCCCCCCCCCCCCCC | 17.14 | 21440633 | |
| 881 | Phosphorylation | SASLTPVTSSSKSSL CCCCCCCCCCCCCEE | 24.89 | 20377248 | |
| 882 | Phosphorylation | ASLTPVTSSSKSSLF CCCCCCCCCCCCEEE | 32.61 | 21440633 | |
| 883 | Phosphorylation | SLTPVTSSSKSSLFL CCCCCCCCCCCEEEC | 32.21 | 24961812 | |
| 884 | Phosphorylation | LTPVTSSSKSSLFLP CCCCCCCCCCEEECC | 36.00 | 20377248 | |
| 885 | Ubiquitination | TPVTSSSKSSLFLPS CCCCCCCCCEEECCC | 46.11 | 24961812 | |
| 886 | Phosphorylation | PVTSSSKSSLFLPSG CCCCCCCCEEECCCC | 33.93 | 22369663 | |
| 887 | Phosphorylation | VTSSSKSSLFLPSGS CCCCCCCEEECCCCC | 27.20 | 22369663 | |
| 892 | Phosphorylation | KSSLFLPSGSSSTSL CCEEECCCCCCCCCC | 54.15 | 22369663 | |
| 894 | Phosphorylation | SLFLPSGSSSTSLKF EEECCCCCCCCCCCC | 26.00 | 22369663 | |
| 895 | Phosphorylation | LFLPSGSSSTSLKFT EECCCCCCCCCCCCH | 40.95 | 22369663 | |
| 896 | Phosphorylation | FLPSGSSSTSLKFTD ECCCCCCCCCCCCHH | 24.58 | 22369663 | |
| 897 | Phosphorylation | LPSGSSSTSLKFTDQ CCCCCCCCCCCCHHH | 39.77 | 25521595 | |
| 898 | Phosphorylation | PSGSSSTSLKFTDQI CCCCCCCCCCCHHHH | 31.35 | 22369663 | |
| 902 | Phosphorylation | SSTSLKFTDQIVHKW CCCCCCCHHHHHHHH | 25.96 | 19779198 | |
| 908 | Acetylation | FTDQIVHKWVRIAPL CHHHHHHHHEEECCC | 36.17 | 24489116 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of BUL1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of BUL1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-70; THR-107; SER-184;SER-194; SER-195; SER-619; SER-896; THR-897 AND SER-898, AND MASSSPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-58, AND MASSSPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-70, AND MASSSPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-107 AND THR-111, ANDMASS SPECTROMETRY. | |
