BSC5_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BSC5_YEAST
• UniProt AC: P53755
• Protein Name: Bypass of stop codon protein 5
• Gene Name: BSC5
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 489
• Protein Description: May be a component of the ubiquitination pathway..
• Protein Sequence: MQESKEPQNKFEGCQRISSSSSTLFGGTSFEEPRCGTSQGKEEDAFACNNGDHCSSITNVQEDDFVLPELLPSFEMYENLLSNIPQSSFDTYFPENPPFYEVASRNQSIPSEGESGNDMRILTGDIVGPDNHEVTVDGRRFASGPAESQIRNYDDTKGIPVENIYALPRIKTPIATELYVTKTAPKFGQLPKHESMLREYTSGDIIHGYFTVENKSTKPIKFDMFYLTLEGTTSSKTQSPFGIQKTTERILRMVDMAASWSYNHEDVNTGEDLCGFFDSIDKTSFGLPNSRILNPGDKRKKFFTFKIPNQLLDVTCKHGHFSHSLLPPTLGFDRPSSSHPELSTLKFSESLGYGRLSERGSSLWLNDSSSGSLINYSINAMIVGKDVASGRVCLMSEKKYSIRIVPFGFQNNPISREKCLKDLEDFDIEIANRLGMIEKVFSKIERAIPIHKEDIQEANRSDQLSPLRGKYEWNAVAGNTENGTLKKKH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Phosphorylation	EGCQRISSSSSTLFG CCCCCCCCCCCCCCC	31.69	28889911
20	Phosphorylation	GCQRISSSSSTLFGG CCCCCCCCCCCCCCC	22.86	28889911
22	Phosphorylation	QRISSSSSTLFGGTS CCCCCCCCCCCCCCC	30.95	28889911
111	Phosphorylation	SRNQSIPSEGESGND CCCCCCCCCCCCCCC	57.47	28889911
239	Phosphorylation	TTSSKTQSPFGIQKT CCCCCCCCCCCCCHH	27.68	25752575
290	Phosphorylation	TSFGLPNSRILNPGD CCCCCCCCCCCCCCC	20.82	28889911
350	Phosphorylation	STLKFSESLGYGRLS HHCCCCCCCCCCCCC	26.37	28889911
471	Phosphorylation	LSPLRGKYEWNAVAG CCCCCCCCEEECCCE	29.06	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	RSP5	P39940	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BSC5_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BSC5_YEAST !!

Protein-Protein Interaction

Oops, there are no PPI records of BSC5_YEAST !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19; SER-22; SER-111 ANDSER-350, AND MASS SPECTROMETRY.
PubMed: 18407956