PSK2_YEAST - dbPTM
PSK2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PSK2_YEAST
UniProt AC Q08217
Protein Name Serine/threonine-protein kinase PSK2
Gene Name PSK2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1101
Subcellular Localization Cytoplasm .
Protein Description Serine/threonine-protein kinase involved in the control of sugar metabolism and translation. Phosphorylates UGP1, which is required for normal glycogen and beta-(1,6)-glucan synthesis. This phosphorylation shifts glucose partitioning toward cell wall glucan synthesis at the expense of glycogen synthesis. Phosphorylates also the glycogen synthase GSY2 and the translation factors CAF20, TIF11 and SRO9..
Protein Sequence MTYPVSAAAPADISYSKNTPLVGLSKPPCLYQHASSSVDSFSSTFSDDDRSDLVAVPNESPHAFSYNPISPNSLGVRLTILRRSLEIMVNSPDILHELKKKAPVIAYPPSLRHTRNLTETATLSASRDPLNGSLISPLVSNMPSPASRPVIQRATSLMVLPDNDTASKLNPAKSELENLLFLLNLALENNSFERASDLHMLSLLNIKKINFDSDIQKSETLKKVLLDSLAEPFFENYKKFPHKDLGSKSQYNEYEEKHDDIVSLADIKPQQDYSRILHPFTSAKNSGPEAIFTCSQQYPWNFKAANDLACLTFGISKNVIKALTLLDLIHTDSRNFVLEKIMNAEDDNQEIVFTGETIPIVQPNSTSNNNVPNLIWASLWAKRKNGLLVCVFEKTPCDYIDVMLNLRDFSVDSIIDTTHFLENFDKKKQQESTSPMTEKKTVKFANEIHDIGSVSHSLSKLIDDVRFGKVFSADDDLLPLSIRVANHVNEERYFTLNCLSENIPCAVTTSVLENEIKLKIHSLPYQAGLFIVDSHTLSLLSFNKSVAKNMFGLRLHELAGSSVTKLVPSLADMISYINKTYPMLNITLPENKGLVLTEHFFRKIEAEMHHDKDSFYTSIGLDGCHKDGNLIKVDVQLRVLNTNAVLLWITHSRDVVIENYTTVPSQLPMLKENEIDVVGSRGSSSASSKKSSEKIPVNTLKAMADLSISSAETISNSDDEVDLNQVNEKLRETSCGKVRGIESNDNNNYDDDMTMVDDPELKHKIELTKMYTQDKSKFVKDDNFKVDEKFIMRIIEPINGEEIKKETNELDKRNSTLKATYLTTPEANIGSQKRIKKFSDFTILQVMGEGAYGKVNLCIHNREHYIVVIKMIFKERILVDTWVRDRKLGTIPSEIQIMATLNKNSQENILKLLDFFEDDDYYYIETPVHGETGSIDLFDVIEFKKDMVEHEAKLVFKQVVASIKHLHDQGIVHRDIKDENVIVDSHGFVKLIDFGSAAYIKSGPFDVFVGTMDYAAPEVLGGSSYKGKPQDIWALGVLLYTIIYKENPYYNIDEILEGELRFDKSEHVSEECISLIKRILTREVDKRPTIDEIYEDKWLKI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MTYPVSAAA
------CCCCCCCCC		48.0824909858
3Phosphorylation-----MTYPVSAAAP
-----CCCCCCCCCC		17.3126447709
6Phosphorylation--MTYPVSAAAPADI
--CCCCCCCCCCCCC		14.0024909858
14PhosphorylationAAAPADISYSKNTPL
CCCCCCCCCCCCCCC		24.7330377154
16PhosphorylationAPADISYSKNTPLVG
CCCCCCCCCCCCCCC		16.7930377154
118PhosphorylationLRHTRNLTETATLSA
CCCCCCCCCCEEEEC		34.5320489023
124PhosphorylationLTETATLSASRDPLN
CCCCEEEECCCCCCC		21.6121440633
155PhosphorylationRPVIQRATSLMVLPD
CCHHHHCCEEEECCC		25.2822369663
156PhosphorylationPVIQRATSLMVLPDN
CHHHHCCEEEECCCC		17.3022369663
222UbiquitinationIQKSETLKKVLLDSL
CCCCHHHHHHHHHHH		48.5315699485
223UbiquitinationQKSETLKKVLLDSLA
CCCHHHHHHHHHHHH		41.0215699485
263PhosphorylationEKHDDIVSLADIKPQ
HHHCCCCCHHHCCCC		20.4128889911
433PhosphorylationKKKQQESTSPMTEKK
HHHHHHCCCCCCCHH		35.7827717283
434PhosphorylationKKQQESTSPMTEKKT
HHHHHCCCCCCCHHH		23.1917563356
437PhosphorylationQESTSPMTEKKTVKF
HHCCCCCCCHHHHHH		48.3030377154
453PhosphorylationNEIHDIGSVSHSLSK
HHHHCHHHHHHHHHH		22.3021551504
455PhosphorylationIHDIGSVSHSLSKLI
HHCHHHHHHHHHHHH		14.7321551504
457PhosphorylationDIGSVSHSLSKLIDD
CHHHHHHHHHHHHHH		27.1721551504
680PhosphorylationNEIDVVGSRGSSSAS
CCEEEECCCCCCCCC		23.1222369663
683PhosphorylationDVVGSRGSSSASSKK
EEECCCCCCCCCCCC		21.7320377248
684PhosphorylationVVGSRGSSSASSKKS
EECCCCCCCCCCCCC		32.5220377248
685PhosphorylationVGSRGSSSASSKKSS
ECCCCCCCCCCCCCC		33.5921551504
687PhosphorylationSRGSSSASSKKSSEK
CCCCCCCCCCCCCCC		44.6420377248
688PhosphorylationRGSSSASSKKSSEKI
CCCCCCCCCCCCCCC		43.7621440633
692PhosphorylationSASSKKSSEKIPVNT
CCCCCCCCCCCCHHH		52.3625752575
699PhosphorylationSEKIPVNTLKAMADL
CCCCCHHHHHHHHHC		29.8420377248
717PhosphorylationSAETISNSDDEVDLN
CCHHHCCCCCCCCHH		39.3827214570
985PhosphorylationDENVIVDSHGFVKLI
CCCEEECCCCEEEEE		18.0228889911
1024PhosphorylationPEVLGGSSYKGKPQD
CHHHCCCCCCCCHHH		33.8519779198
1025PhosphorylationEVLGGSSYKGKPQDI
HHHCCCCCCCCHHHH		26.0019779198
1065PhosphorylationGELRFDKSEHVSEEC
CCCCCCCCCCCCHHH		34.4819779198
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PSK2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PSK2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PSK2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PSK1_YEASTPSK1physical
11805837
FUN30_YEASTFUN30physical
11805837
UGPA1_YEASTUGP1physical
12372297
CAF20_YEASTCAF20physical
12372297
SRO9_YEASTSRO9physical
12372297
PGM1_YEASTPGM1genetic
12372297
PGM2_YEASTPGM2genetic
12372297
SIP1_YEASTSIP1genetic
12372297
DDP1_YEASTDDP1genetic
12372297
PUR91_YEASTADE16genetic
12372297
CARA_YEASTCPA1genetic
12372297
RBS1_YEASTRBS1genetic
12372297
DED1_YEASTDED1genetic
12372297
DBP1_YEASTDBP1genetic
12372297
EDC1_YEASTEDC1genetic
12372297
POP4_YEASTPOP4genetic
12372297
UBA2_YEASTUBA2genetic
12372297
REF2_YEASTREF2genetic
12372297
UGPA1_YEASTUGP1genetic
12372297
OCA5_YEASTOCA5genetic
19269370
DEP1_YEASTDEP1genetic
20093466
RL19A_YEASTRPL19Bgenetic
20093466
RL19B_YEASTRPL19Bgenetic
20093466
SEC66_YEASTSEC66genetic
20093466
SUL1_YEASTSUL1genetic
20093466
CSM1_YEASTCSM1genetic
20093466
CG23_YEASTCLB3genetic
20093466
PHO2_YEASTPHO2genetic
20093466
PMT1_YEASTPMT1genetic
20093466
PEX19_YEASTPEX19genetic
20093466
NHP10_YEASTNHP10genetic
20093466
VMS1_YEASTVMS1genetic
20093466
MNN10_YEASTMNN10genetic
20093466
FCY2_YEASTFCY2genetic
20093466
SC6B1_YEASTSBH1genetic
20093466
PEA2_YEASTPEA2genetic
20093466
MTO1_YEASTMTO1genetic
20093466
ATC1_YEASTPMR1genetic
20093466
PEX14_YEASTPEX14genetic
20093466
YGK1_YEASTYGL101Wgenetic
20093466
YGI1_YEASTYGL081Wgenetic
20093466
RS25A_YEASTRPS25Agenetic
20093466
SYF2_YEASTSYF2genetic
20093466
TBP7_YEASTYTA7genetic
20093466
SSBP1_YEASTSBP1genetic
20093466
PACC_YEASTRIM101genetic
20093466
YHI9_YEASTYHI9genetic
20093466
DNPEP_YEASTAPE4genetic
20093466
YHS7_YEASTYHR127Wgenetic
20093466
CHS7_YEASTCHS7genetic
20093466
RE104_YEASTREC104genetic
20093466
3HAO_YEASTBNA1genetic
20093466
CYC1_YEASTCYC1genetic
20093466
FRMSR_YEASTYKL069Wgenetic
20093466
PEX13_YEASTPEX13genetic
20093466
YL287_YEASTYLR287Cgenetic
20093466
FKS1_YEASTFKS1genetic
20093466
CTK3_YEASTCTK3genetic
20093466
PEX12_YEASTPEX12genetic
20093466
MRE11_YEASTMRE11genetic
20093466
JNM1_YEASTJNM1genetic
20093466
NST1_YEASTNST1genetic
20093466
APJ1_YEASTAPJ1genetic
20093466
SFG1_YEASTSFG1genetic
20093466
HSP7F_YEASTSSE1genetic
20093466
METK1_YEASTSAM1physical
20489023
UGPA1_YEASTUGP1physical
20489023
PABS_YEASTABZ1physical
21460040
SYA_YEASTALA1physical
21460040
ARA2_YEASTARA2physical
21460040
CATA_YEASTCTA1physical
21460040
MCFS2_YEASTEHT1physical
21460040
GLNA_YEASTGLN1physical
21460040
GRE3_YEASTGRE3physical
21460040
MASY_YEASTMLS1physical
21460040
PFKA2_YEASTPFK2physical
21460040
PFS2_YEASTPFS2physical
21460040
PGM1_YEASTPGM1physical
21460040
UAP1_YEASTQRI1physical
21460040
RIR4_YEASTRNR4physical
21460040
SERC_YEASTSER1physical
21460040
IF4A_YEASTTIF2physical
21460040
TOM70_YEASTTOM70physical
21460040
YH11A_YEASTYHR214C-Cphysical
21460040
DOHH_YEASTLIA1physical
21460040
YN93_YEASTYNR064Cphysical
21460040
YP077_YEASTYPL077Cphysical
21460040
IES3_YEASTIES3genetic
21127252
PHO80_YEASTPHO80genetic
21127252
RAD52_YEASTRAD52genetic
21127252
VPS71_YEASTVPS71genetic
21127252
ROM2_YEASTROM2genetic
22296835
SSD1_YEASTSSD1genetic
22296835
UGPA1_YEASTUGP1genetic
22296835
APC2_YEASTAPC2genetic
22282571
SHS1_YEASTSHS1genetic
22282571
MLC1_YEASTMLC1genetic
22282571
MNN10_YEASTMNN10genetic
22282571
PEX12_YEASTPEX12genetic
22282571
YL287_YEASTYLR287Cgenetic
22282571
FRMSR_YEASTYKL069Wgenetic
22282571
PEA2_YEASTPEA2genetic
22282571
YHS7_YEASTYHR127Wgenetic
22282571
3HAO_YEASTBNA1genetic
22282571
PEX13_YEASTPEX13genetic
22282571
NST1_YEASTNST1genetic
22282571
MRE11_YEASTMRE11genetic
22282571
DEP1_YEASTDEP1genetic
22282571
PMT1_YEASTPMT1genetic
22282571
PACC_YEASTRIM101genetic
22282571
YGI1_YEASTYGL081Wgenetic
22282571
CSM1_YEASTCSM1genetic
22282571
MTO1_YEASTMTO1genetic
22282571
TBP7_YEASTYTA7genetic
22282571
CG23_YEASTCLB3genetic
22282571
CYC1_YEASTCYC1genetic
22282571
ATC1_YEASTPMR1genetic
22282571
PEX19_YEASTPEX19genetic
22282571
YGK1_YEASTYGL101Wgenetic
22282571
RL19A_YEASTRPL19Bgenetic
22282571
RL19B_YEASTRPL19Bgenetic
22282571
APJ1_YEASTAPJ1genetic
22282571
YHI9_YEASTYHI9genetic
22282571
RS25A_YEASTRPS25Agenetic
22282571
PHO2_YEASTPHO2genetic
22282571
VMS1_YEASTVMS1genetic
22282571
PEX14_YEASTPEX14genetic
22282571
CTK3_YEASTCTK3genetic
22282571
FKS1_YEASTFKS1genetic
22282571
SYF2_YEASTSYF2genetic
22282571
RE104_YEASTREC104genetic
22282571
SFG1_YEASTSFG1genetic
22282571
FCY2_YEASTFCY2genetic
22282571
HSP7F_YEASTSSE1genetic
22282571
DNPEP_YEASTAPE4genetic
22282571
SSBP1_YEASTSBP1genetic
22282571
SC6B1_YEASTSBH1genetic
22282571
NHP10_YEASTNHP10genetic
22282571
MDM10_YEASTMDM10genetic
27708008
PMP3_YEASTPMP3genetic
27708008
DEP1_YEASTDEP1genetic
27708008
RL19A_YEASTRPL19Bgenetic
27708008
RL19B_YEASTRPL19Bgenetic
27708008
SEC66_YEASTSEC66genetic
27708008
SWC5_YEASTSWC5genetic
27708008
CSM1_YEASTCSM1genetic
27708008
NHP10_YEASTNHP10genetic
27708008
PEX19_YEASTPEX19genetic
27708008
BRE1_YEASTBRE1genetic
27708008
CYK3_YEASTCYK3genetic
27708008
VMS1_YEASTVMS1genetic
27708008
TPS2_YEASTTPS2genetic
27708008
BMH2_YEASTBMH2genetic
27708008
MKC7_YEASTMKC7genetic
27708008
MNN10_YEASTMNN10genetic
27708008
FCY2_YEASTFCY2genetic
27708008
GET2_YEASTGET2genetic
27708008
PEA2_YEASTPEA2genetic
27708008
YGI1_YEASTYGL081Wgenetic
27708008
YGK1_YEASTYGL101Wgenetic
27708008
MRM2_YEASTMRM2genetic
27708008
MED5_YEASTNUT1genetic
27708008
PEX14_YEASTPEX14genetic
27708008
ATC1_YEASTPMR1genetic
27708008
MTO1_YEASTMTO1genetic
27708008
SYF2_YEASTSYF2genetic
27708008
SSBP1_YEASTSBP1genetic
27708008
YHS7_YEASTYHR127Wgenetic
27708008
RE104_YEASTREC104genetic
27708008
IST3_YEASTIST3genetic
27708008
3HAO_YEASTBNA1genetic
27708008
CYC1_YEASTCYC1genetic
27708008
HOC1_YEASTHOC1genetic
27708008
FRMSR_YEASTYKL069Wgenetic
27708008
CCW12_YEASTCCW12genetic
27708008
FKS1_YEASTFKS1genetic
27708008
CTK3_YEASTCTK3genetic
27708008
NAB6_YEASTNAB6genetic
27708008
MSC1_YEASTMSC1genetic
27708008
PEX12_YEASTPEX12genetic
27708008
HSP7F_YEASTSSE1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PSK2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-118; THR-155; SER-156;SER-680; SER-692 AND SER-717, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-434, AND MASSSPECTROMETRY.

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