SIP1_YEAST - dbPTM
SIP1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SIP1_YEAST
UniProt AC P32578
Protein Name SNF1 protein kinase subunit beta-1
Gene Name SIP1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 815
Subcellular Localization Cytoplasm . Vacuole membrane
Peripheral membrane protein
Cytoplasmic side . Resides in the cytosol during growth in glucose and relocalizes to the vacuolar membrane in response to carbon stress.
Protein Description Beta subunit of the SNF1 kinase complex, which is required for transcriptional, metabolic, and developmental adaptations in response to glucose limitation. Has a structural role, mediating heterotrimer formation, and a regulatory role, defining carbon source-regulated subcellular location and substrate specificity of the SNF1 kinase complex. Promotes the PKA-regulated relocalization of the SNF1 kinase complex to the vacuolar membrane in response to various types of carbon stress..
Protein Sequence MGNSPSTQDPSHSTKKEHGHHFHDAFNKDRQGSITSQLFNNRKSTHKRRASHTSEHNGAIPPRMQLLASHDPSTDCDGRMSSDTTIDKGPSHLFKKDYSLSSAADVNDTTLANLTLSDDHDVGAPEEQVKSPSFLSPGPSMATVKRTKSDLDDLSTLNYTMVDETTENERNDKPHHERHRSSIIALKKNLLESSATASPSPTRSSSVHSASLPALTKTDSIDIPVRQPYSKKPSIHAYQYQYLNNDETFSENSQMDKEGNSDSVDAEAGVLQSEDMVLNQSLLQNALKKDMQRLSRVNSSNSMYTAERISHANNNGNIENNTRNKGNAGGSNDDFTAPISATAKMMMKLYGDKTLMERDLNKHHNKTKKAQNKKIRSVSNSRRSSFASLHSLQSRKSILTNGLNLQPLHPLHPIINDNESQYSAPQHREISHHSNSMSSMSSISSTNSTENTLVVLKWKDDGTVAATTEVFIVSTDIASALKEQRELTLDENASLDSEKQLNPRIRMVYDDVHKEWFVPDLFLPAGIYRLQFSINGILTHSNFLPTATDSEGNFVNWFEVLPGYHTIEPFRNEADIDSQVEPTLDEELPKRPELKRFPSSSRKSSYYSAKGVERPSTPFSDYRGLSRSSSINMRDSFVRLKASSLDLMAEVKPERLVYSNEIPNLFNIGDGSTISVKGDSDDVHPQEPPSFTHRVVDCNQDDLFATLQQGGNIDAETAEAVFLSRYPVPDLPIYLNSSYLNRILNQSNQNSESHERDEGAINHIIPHVNLNHLLTSSIRDEIISVACTTRYEGKFITQVVYAPCYYKTQKSQISN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Myristoylation------MGNSPSTQD
------CCCCCCCCC		43.24-
4Phosphorylation----MGNSPSTQDPS
----CCCCCCCCCCC		17.9430377154
6Phosphorylation--MGNSPSTQDPSHS
--CCCCCCCCCCCCC		38.2230377154
7Phosphorylation-MGNSPSTQDPSHST
-CCCCCCCCCCCCCC		40.1330377154
11PhosphorylationSPSTQDPSHSTKKEH
CCCCCCCCCCCCCHH		38.0630377154
13PhosphorylationSTQDPSHSTKKEHGH
CCCCCCCCCCCHHCC		46.3830377154
14PhosphorylationTQDPSHSTKKEHGHH
CCCCCCCCCCHHCCC		40.4930377154
33PhosphorylationFNKDRQGSITSQLFN
CCCCCCCCHHHHHHH		17.8519823750
35PhosphorylationKDRQGSITSQLFNNR
CCCCCCHHHHHHHCC		16.4719684113
36PhosphorylationDRQGSITSQLFNNRK
CCCCCHHHHHHHCCC		24.1828889911
51PhosphorylationSTHKRRASHTSEHNG
CCCCHHCCCCCCCCC		26.0325005228
53PhosphorylationHKRRASHTSEHNGAI
CCHHCCCCCCCCCCC		33.0619684113
54PhosphorylationKRRASHTSEHNGAIP
CHHCCCCCCCCCCCC		31.2825005228
81PhosphorylationTDCDGRMSSDTTIDK
CCCCCCCCCCCCCCC		24.5728889911
82PhosphorylationDCDGRMSSDTTIDKG
CCCCCCCCCCCCCCC		29.6327214570
84PhosphorylationDGRMSSDTTIDKGPS
CCCCCCCCCCCCCHH		27.8319779198
99PhosphorylationHLFKKDYSLSSAADV
HHCCCCCCCCCCCCC		31.7328889911
101PhosphorylationFKKDYSLSSAADVND
CCCCCCCCCCCCCCC		16.4028889911
102PhosphorylationKKDYSLSSAADVNDT
CCCCCCCCCCCCCCC		32.5428889911
131PhosphorylationAPEEQVKSPSFLSPG
CCHHHCCCCCCCCCC		27.2421440633
133PhosphorylationEEQVKSPSFLSPGPS
HHHCCCCCCCCCCCC		46.0028152593
136PhosphorylationVKSPSFLSPGPSMAT
CCCCCCCCCCCCCHH		26.2925752575
140PhosphorylationSFLSPGPSMATVKRT
CCCCCCCCCHHEECC		27.2821440633
143PhosphorylationSPGPSMATVKRTKSD
CCCCCCHHEECCHHH		20.2321440633
145UbiquitinationGPSMATVKRTKSDLD
CCCCHHEECCHHHHH		50.4223749301
147PhosphorylationSMATVKRTKSDLDDL
CCHHEECCHHHHHHH		29.2324961812
149PhosphorylationATVKRTKSDLDDLST
HHEECCHHHHHHHHH		42.6728889911
155PhosphorylationKSDLDDLSTLNYTMV
HHHHHHHHHCCEEEE		37.5330377154
156PhosphorylationSDLDDLSTLNYTMVD
HHHHHHHHCCEEEEE		26.7319779198
165PhosphorylationNYTMVDETTENERND
CEEEEECCCCCCCCC		34.6424961812
166PhosphorylationYTMVDETTENERNDK
EEEEECCCCCCCCCC		34.4624961812
181PhosphorylationPHHERHRSSIIALKK
CCHHHHHHHHHHHHH		21.5522369663
182PhosphorylationHHERHRSSIIALKKN
CHHHHHHHHHHHHHH		20.2622369663
193PhosphorylationLKKNLLESSATASPS
HHHHHHHCCCCCCCC		25.8322369663
194PhosphorylationKKNLLESSATASPSP
HHHHHHCCCCCCCCC		21.9122369663
196PhosphorylationNLLESSATASPSPTR
HHHHCCCCCCCCCCC		29.6222369663
198PhosphorylationLESSATASPSPTRSS
HHCCCCCCCCCCCCC		22.8922369663
200PhosphorylationSSATASPSPTRSSSV
CCCCCCCCCCCCCCC		36.0922369663
202PhosphorylationATASPSPTRSSSVHS
CCCCCCCCCCCCCCC		47.7420377248
204PhosphorylationASPSPTRSSSVHSAS
CCCCCCCCCCCCCCC		29.4622369663
205PhosphorylationSPSPTRSSSVHSASL
CCCCCCCCCCCCCCC		32.8420377248
206PhosphorylationPSPTRSSSVHSASLP
CCCCCCCCCCCCCCC		25.7022369663
209PhosphorylationTRSSSVHSASLPALT
CCCCCCCCCCCCCCC		19.8722369663
211PhosphorylationSSSVHSASLPALTKT
CCCCCCCCCCCCCCC		37.5922369663
216PhosphorylationSASLPALTKTDSIDI
CCCCCCCCCCCCCCC		33.7222369663
218PhosphorylationSLPALTKTDSIDIPV
CCCCCCCCCCCCCCC		29.7322890988
220PhosphorylationPALTKTDSIDIPVRQ
CCCCCCCCCCCCCCC		27.6522369663
229PhosphorylationDIPVRQPYSKKPSIH
CCCCCCCCCCCCCEE		25.4519779198
230PhosphorylationIPVRQPYSKKPSIHA
CCCCCCCCCCCCEEE		40.6729136822
234PhosphorylationQPYSKKPSIHAYQYQ
CCCCCCCCEEEEEEE		35.5721440633
238PhosphorylationKKPSIHAYQYQYLNN
CCCCEEEEEEEECCC		8.1328889911
242PhosphorylationIHAYQYQYLNNDETF
EEEEEEEECCCCCCC		13.3819779198
248PhosphorylationQYLNNDETFSENSQM
EECCCCCCCCCCCCC		35.0119779198
295PhosphorylationKKDMQRLSRVNSSNS
HHHHHHHHHCCCCCC		36.0522369663
299PhosphorylationQRLSRVNSSNSMYTA
HHHHHCCCCCCHHHH		28.2122369663
300PhosphorylationRLSRVNSSNSMYTAE
HHHHCCCCCCHHHHH		27.9322369663
302PhosphorylationSRVNSSNSMYTAERI
HHCCCCCCHHHHHHH		18.3422369663
304PhosphorylationVNSSNSMYTAERISH
CCCCCCHHHHHHHHC		11.5622369663
305PhosphorylationNSSNSMYTAERISHA
CCCCCHHHHHHHHCC		17.2522369663
331PhosphorylationNKGNAGGSNDDFTAP
CCCCCCCCCCCCCCC		35.8522369663
336PhosphorylationGGSNDDFTAPISATA
CCCCCCCCCCHHHHH		38.2222369663
340PhosphorylationDDFTAPISATAKMMM
CCCCCCHHHHHHHHH		20.6419823750
342PhosphorylationFTAPISATAKMMMKL
CCCCHHHHHHHHHHH		21.7419823750
350PhosphorylationAKMMMKLYGDKTLME
HHHHHHHHCCHHHHH		20.1228889911
353AcetylationMMKLYGDKTLMERDL
HHHHHCCHHHHHHHH		38.9125381059
377PhosphorylationAQNKKIRSVSNSRRS
HHHHHHHHHHHCHHH		33.1128889911
379PhosphorylationNKKIRSVSNSRRSSF
HHHHHHHHHCHHHCH		30.2717330950
381PhosphorylationKIRSVSNSRRSSFAS
HHHHHHHCHHHCHHH		22.8924961812
384PhosphorylationSVSNSRRSSFASLHS
HHHHCHHHCHHHHHH		28.7922369663
385PhosphorylationVSNSRRSSFASLHSL
HHHCHHHCHHHHHHH		24.0322369663
388PhosphorylationSRRSSFASLHSLQSR
CHHHCHHHHHHHHHH		25.3022369663
391PhosphorylationSSFASLHSLQSRKSI
HCHHHHHHHHHHHHH		33.1422369663
394PhosphorylationASLHSLQSRKSILTN
HHHHHHHHHHHHHHC		47.1422369663
397PhosphorylationHSLQSRKSILTNGLN
HHHHHHHHHHHCCCC		23.0128889911
436PhosphorylationEISHHSNSMSSMSSI
HHCCCCCCCCCCCCC		24.0528889911
439PhosphorylationHHSNSMSSMSSISST
CCCCCCCCCCCCCCC		17.6528889911
445PhosphorylationSSMSSISSTNSTENT
CCCCCCCCCCCCCCE		29.9119779198
488PhosphorylationLKEQRELTLDENASL
HHHHHHCCCCCCCCC		27.6622369663
494PhosphorylationLTLDENASLDSEKQL
CCCCCCCCCCCHHHC		44.2722369663
497PhosphorylationDENASLDSEKQLNPR
CCCCCCCCHHHCCCC		52.5722369663
499UbiquitinationNASLDSEKQLNPRIR
CCCCCCHHHCCCCCE		65.1323749301
578PhosphorylationRNEADIDSQVEPTLD
CCCCCCCCCCCCCCC		36.1428889911
599PhosphorylationPELKRFPSSSRKSSY
HHHHCCCCCCCCCCC		37.9328132839
600PhosphorylationELKRFPSSSRKSSYY
HHHCCCCCCCCCCCC		34.1127214570
604PhosphorylationFPSSSRKSSYYSAKG
CCCCCCCCCCCCCCC		23.5928889911
605PhosphorylationPSSSRKSSYYSAKGV
CCCCCCCCCCCCCCC		31.0028889911
608PhosphorylationSRKSSYYSAKGVERP
CCCCCCCCCCCCCCC		18.4428889911
616PhosphorylationAKGVERPSTPFSDYR
CCCCCCCCCCCCCCC		55.7422369663
617PhosphorylationKGVERPSTPFSDYRG
CCCCCCCCCCCCCCC		30.9122369663
620PhosphorylationERPSTPFSDYRGLSR
CCCCCCCCCCCCCCC		34.6322369663
622PhosphorylationPSTPFSDYRGLSRSS
CCCCCCCCCCCCCCC		12.8422369663
626PhosphorylationFSDYRGLSRSSSINM
CCCCCCCCCCCCCCC		32.7022369663
628PhosphorylationDYRGLSRSSSINMRD
CCCCCCCCCCCCCCH		25.6822369663
629PhosphorylationYRGLSRSSSINMRDS
CCCCCCCCCCCCCHH		33.8422369663
630PhosphorylationRGLSRSSSINMRDSF
CCCCCCCCCCCCHHH		21.1622369663
636PhosphorylationSSINMRDSFVRLKAS
CCCCCCHHHHHHHHH		18.4422369663
643PhosphorylationSFVRLKASSLDLMAE
HHHHHHHHHHHHHEE		29.8222369663
644PhosphorylationFVRLKASSLDLMAEV
HHHHHHHHHHHHEEC		30.6622369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SIP1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SIP1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SIP1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SNF1_YEASTSNF1physical
9121458
AAKG_YEASTSNF4physical
9121458
GAL83_YEASTGAL83genetic
14993292
SIP2_YEASTSIP2genetic
14993292
GAL83_YEASTGAL83genetic
10990457
SIP2_YEASTSIP2genetic
10990457
SNF1_YEASTSNF1physical
16554755
RAD4_YEASTRAD4physical
16554755
AAKG_YEASTSNF4physical
16554755
MBA1_YEASTMBA1genetic
20093466
BRE1_YEASTBRE1genetic
20093466
TPS2_YEASTTPS2genetic
20093466
SLX8_YEASTSLX8genetic
20093466
SA155_YEASTSAP155genetic
20093466
MED5_YEASTNUT1genetic
20093466
AAKG_YEASTSNF4genetic
20093466
PALF_YEASTRIM8genetic
20093466
TBP7_YEASTYTA7genetic
20093466
YOR1_YEASTYOR1genetic
20093466
AIM18_YEASTAIM18genetic
20093466
AYR1_YEASTAYR1genetic
20093466
GLG2_YEASTGLG2genetic
20093466
RS21B_YEASTRPS21Bgenetic
20093466
PTK2_YEASTPTK2genetic
20093466
DOHH_YEASTLIA1genetic
20093466
SAC1_YEASTSAC1genetic
20093466
CBT1_YEASTCBT1genetic
20093466
DBP7_YEASTDBP7genetic
20093466
RS21A_YEASTRPS21Agenetic
20093466
PAM17_YEASTPAM17genetic
20093466
YL194_YEASTYLR194Cgenetic
20093466
ROM2_YEASTROM2genetic
20093466
SWS2_YEASTSWS2genetic
20093466
HAP5_YEASTHAP5genetic
20093466
QCR2_YEASTQCR2genetic
20093466
EMI2_YEASTEMI2physical
20489023
MPM1_YEASTMPM1physical
20489023
SNF1_YEASTSNF1physical
20489023
AAKG_YEASTSNF4physical
20489023
STI1_YEASTSTI1physical
20489023
GAL83_YEASTGAL83genetic
20545859
SIP2_YEASTSIP2genetic
20545859
SPO14_YEASTSPO14genetic
23891562
AAKG_YEASTSNF4genetic
23891562
SIP2_YEASTSIP2genetic
24486034
GAL83_YEASTGAL83genetic
24486034
GAL83_YEASTGAL83genetic
25116136
SIP2_YEASTSIP2genetic
25116136
SIP2_YEASTSIP2genetic
26394309
GAL83_YEASTGAL83genetic
26394309
SWD1_YEASTSWD1genetic
27708008
SLA1_YEASTSLA1genetic
27708008
SIF2_YEASTSIF2genetic
27708008
AGP1_YEASTAGP1genetic
27708008
SNT1_YEASTSNT1genetic
27708008
IMG2_YEASTIMG2genetic
27708008
SA155_YEASTSAP155genetic
27708008
PALF_YEASTRIM8genetic
27708008
AAKG_YEASTSNF4genetic
27708008
MED5_YEASTNUT1genetic
27708008
CHO2_YEASTCHO2genetic
27708008
TBP7_YEASTYTA7genetic
27708008
MTC6_YEASTMTC6genetic
27708008
AIM18_YEASTAIM18genetic
27708008
RS21B_YEASTRPS21Bgenetic
27708008
GLG2_YEASTGLG2genetic
27708008
3HAO_YEASTBNA1genetic
27708008
DOHH_YEASTLIA1genetic
27708008
ILM1_YEASTILM1genetic
27708008
VPS51_YEASTVPS51genetic
27708008
DBP7_YEASTDBP7genetic
27708008
RS21A_YEASTRPS21Agenetic
27708008
YL194_YEASTYLR194Cgenetic
27708008
LIPB_YEASTLIP2genetic
27708008
ROM2_YEASTROM2genetic
27708008
AEP2_YEASTAEP2genetic
27708008
SIN3_YEASTSIN3genetic
27708008
COQ10_YEASTCOQ10genetic
27708008
IRA2_YEASTIRA2genetic
27708008
YO162_YEASTYOL162Wgenetic
27708008
RRP6_YEASTRRP6genetic
27708008
CYC2_YEASTCYC2genetic
27708008
BUD21_YEASTBUD21genetic
27708008
IDH2_YEASTIDH2genetic
27708008
HAP5_YEASTHAP5genetic
27708008
SIP2_YEASTSIP2genetic
27592031
SIP2_YEASTSIP2genetic
28760824
GAL83_YEASTGAL83genetic
28760824
RUD3_YEASTRUD3genetic
29674565
BRE1_YEASTBRE1genetic
29674565
UME6_YEASTUME6genetic
29674565
SWF1_YEASTSWF1genetic
29674565
MDM10_YEASTMDM10genetic
29674565
PP2C1_YEASTPTC1genetic
29674565
TAF12_YEASTTAF12genetic
29674565
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SIP1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-133; SER-136; SER-149;SER-193; SER-200; SER-206; SER-209; SER-220; SER-299; SER-331;SER-494; SER-497; SER-616; SER-643 AND SER-644, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-331, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-198; SER-200; SER-220;SER-331; SER-494; SER-497 AND SER-643, AND MASS SPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-204 AND SER-209, ANDMASS SPECTROMETRY.

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