SPO14_YEAST - dbPTM
SPO14_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SPO14_YEAST
UniProt AC P36126
Protein Name Phospholipase D1
Gene Name SPO14
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1683
Subcellular Localization
Protein Description Required for meiosis and spore formation. Seems to be involved in the coordinate induction of late meiotic events. PLD activity is induced under sporulation conditions and seems to be necessary to complete the meiotic cycle, but not for vegetative cell growth..
Protein Sequence MSNVSTASGTHFAPPQADRSVTEEVDRVNSRPDELENQEVLRQLPENGNLTSSLQREKRRTPNGKEAERKHALPKSFVDRNLSDVSPNHSLDHIMHSNEHDPRRGSDEENMHRLYNNLHSSNNNVHSKRNSKREEERAPQRRSSSVAYTQQQFNGWKKEFGHAFKKISAIGRLKSSVNSPTPAGSGHRHNQHQHQQVNEEDLYTQRLASDLLDSLLAGCPASLFASTQFLRDEHGKRRAPLLLAKLDVRVSPLKNDNNILDITNSNHNHRGNNNNNTGENSDRRPSIPRSSSIISISSNVAEFMYSRNENSLFRIHLEYGIDEDRLKWSIIRSYKDIKSLHHKLKIVAFQQLTISKLYSDNNRYHSLQLPHFPHYKEMVKERNVMEKKAENKPSSAASAPHTSENNNNDNGSNITSLETLSSSEISEFNIDNVKMKHLQDLIDEPDDFSQPIHLRLERYLRLLNIALCLRPHANRLFEFYELSPLGNLLSRESGFQGKQGYLVIRSTAKAQGWRVSHFGKHAFKDMIDRHTTKWFLVRNSYLTYVSDLSSTTPLDVFLIDWKFKVRFSGNKNNILDNENEINWIIHDPNLEINDELEEFGIENDANNILDKNGKSKTHQKKSNISSKLLLLTLENSERKLKIICKSESSLKQWMSSIIKMSTSTPWSKPNRFGSFAPVRTNSFCKFLVDGRDYFWSLSEALLMAKDVIYIHDWWLSPELYLRRPVKGNQGFRIDRMLKSCAEKGIKIFIVIYRNVGNIVGTDSLWTKHSMLNLHPNIHIIRSPNQWLQNTYFWAHHEKFVVIDETFAFIGGTDLCYGRYDTFEHVLRDDAESLLDQNFPGKDYSNARIADFHDLDKPFESMYDRKVIPRMPWHDVQMMTLGEPARDLARHFVQRWNYLLRAKRPSRLTPLLTPPSDLTAEELKSLPMFEILREKSTCETQILRSAGNWSLGLKETECSIQNAYLKLIEQSEHFIYIENQFFITSTVWNGTCVLNKIGDALVDRIVKANQEKKPWKAFILIPLMPGFDSPVDTAEASSLRLIMQFQYQSISRGEHSTFSKLKKLNIDPAQYIQFFSLRKWSTFAPNERLITEQLYVHAKILIADDRRCIIGSANINERSQLGNRDSEVAILIRDTDLIKTKMNGDDYYAGKFPWELRQRLMREHLGCDVDLVEFVEKKFERFEKFAAKNYEKLHTLSKEGDSGNNWSDREMIDSAMIELGYREIFGCKFSPQWKSGHGNSVDDGSTQCGINEKEVGREDENVYEKFFNSVDYGKSSRKRTPLPKHNFASLGLTFNHRAGIENVGIRDHKVLSTDPRLRKNDEHKKEVDGYGPDCWKKESNKKFKADATEQLKEWALNSLASKVLDDKEMIKSEIPEGFSNYLPNEKDLEMYLTDKTVTNRNKWSMLKRICYLQYLSHKLDERKTQRLKKIKDMRRHLSSSTESTRNGSNSLPLNEKSNEGESTNVDQDIEGDEYHRLHEDILKNQELDDGSLDDLLSQIIPKITNFNSGEIDDAKKEELLKLNFIDPYSFEDPLISSFSEGLWFTIALRNTLLYKLVFHCQPDNAVQNWKEYGEFTELEQEFQINQEKLIDLEAENINSTTTNVVDKDREKEKMRKAAELRMKLSGSLLYGFNQKVFDKHTAQRILERIHGHLVIFPTEWLAKEVESRNWIFNSDRLSPMEIYN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSNVSTASG
------CCCCCCCCC		58.1922814378
2Phosphorylation------MSNVSTASG
------CCCCCCCCC		58.1922369663
5Phosphorylation---MSNVSTASGTHF
---CCCCCCCCCCCC		23.6222369663
6Phosphorylation--MSNVSTASGTHFA
--CCCCCCCCCCCCC		22.1422369663
8PhosphorylationMSNVSTASGTHFAPP
CCCCCCCCCCCCCCC		44.2922369663
10PhosphorylationNVSTASGTHFAPPQA
CCCCCCCCCCCCCCC		16.0122369663
20PhosphorylationAPPQADRSVTEEVDR
CCCCCCCCCHHHHHH		33.6628889911
22PhosphorylationPQADRSVTEEVDRVN
CCCCCCCHHHHHHHH		27.8929688323
30PhosphorylationEEVDRVNSRPDELEN
HHHHHHHCCCHHHHC		42.1917330950
52PhosphorylationPENGNLTSSLQREKR
CCCCCCCHHHHHHHH		32.0228132839
53PhosphorylationENGNLTSSLQREKRR
CCCCCCHHHHHHHHC		24.2428889911
106PhosphorylationEHDPRRGSDEENMHR
CCCCCCCCCHHHHHH		39.7828889911
143PhosphorylationERAPQRRSSSVAYTQ
HHCCCHHHHHHHHHH		29.2019779198
144PhosphorylationRAPQRRSSSVAYTQQ
HCCCHHHHHHHHHHH		27.3328889911
145PhosphorylationAPQRRSSSVAYTQQQ
CCCHHHHHHHHHHHH		16.4128889911
148PhosphorylationRRSSSVAYTQQQFNG
HHHHHHHHHHHHHHC		11.7019779198
263PhosphorylationDNNILDITNSNHNHR
CCCCEECCCCCCCCC		32.0627214570
265PhosphorylationNILDITNSNHNHRGN
CCEECCCCCCCCCCC		30.7125005228
281PhosphorylationNNNTGENSDRRPSIP
CCCCCCCCCCCCCCC		28.3528889911
286PhosphorylationENSDRRPSIPRSSSI
CCCCCCCCCCCCCCE		43.3325005228
426PhosphorylationTLSSSEISEFNIDNV
ECCCCCCCCCCCCCH		31.8927214570
544PhosphorylationVRNSYLTYVSDLSST
EECCEEEEHHCCCCC		8.7219779198
549PhosphorylationLTYVSDLSSTTPLDV
EEEHHCCCCCCCCCE		30.5419779198
625PhosphorylationHQKKSNISSKLLLLT
HHCCCCCCHHHHHHH		26.1828889911
626PhosphorylationQKKSNISSKLLLLTL
HCCCCCCHHHHHHHH		24.4328889911
627UbiquitinationKKSNISSKLLLLTLE
CCCCCCHHHHHHHHC		36.0417644757
639UbiquitinationTLENSERKLKIICKS
HHCCCCCCEEEEECC		50.5117644757
646PhosphorylationKLKIICKSESSLKQW
CEEEEECCHHHHHHH		38.0027017623
655PhosphorylationSSLKQWMSSIIKMST
HHHHHHHHHHHHHHC		18.5421551504
656PhosphorylationSLKQWMSSIIKMSTS
HHHHHHHHHHHHHCC		16.5421551504
659UbiquitinationQWMSSIIKMSTSTPW
HHHHHHHHHHCCCCC		25.7317644757
662PhosphorylationSSIIKMSTSTPWSKP
HHHHHHHCCCCCCCC		32.8727017623
668UbiquitinationSTSTPWSKPNRFGSF
HCCCCCCCCCCCCCC		42.3017644757
705UbiquitinationSEALLMAKDVIYIHD
HHHHHHHCCEEEEEC		38.2617644757
739PhosphorylationRIDRMLKSCAEKGIK
CHHHHHHHHHHHCCE		18.0126447709
767AcetylationGTDSLWTKHSMLNLH
CCCCHHCCCCHHCCC		23.3124489116
832PhosphorylationVLRDDAESLLDQNFP
HHHHCHHHHHHCCCC		35.6327214570
860PhosphorylationDLDKPFESMYDRKVI
CCCCCCHHCCCCCCC		24.0327017623
862PhosphorylationDKPFESMYDRKVIPR
CCCCHHCCCCCCCCC		23.1327017623
1061UbiquitinationHSTFSKLKKLNIDPA
CCHHHHHHHCCCCHH		59.9717644757
1062UbiquitinationSTFSKLKKLNIDPAQ
CHHHHHHHCCCCHHH		58.1417644757
1078UbiquitinationIQFFSLRKWSTFAPN
HHHHCCCCCCCCCCC		51.2817644757
1206PhosphorylationGDSGNNWSDREMIDS
CCCCCCCCCHHHHHH		28.9828889911
1239PhosphorylationWKSGHGNSVDDGSTQ
CCCCCCCCCCCCCCC		31.3621551504
1244PhosphorylationGNSVDDGSTQCGINE
CCCCCCCCCCCCCCH		23.4623749301
1245PhosphorylationNSVDDGSTQCGINEK
CCCCCCCCCCCCCHH		33.1521551504
1268PhosphorylationVYEKFFNSVDYGKSS
HHHHHHHHCCCCCCC		15.9422369663
1341UbiquitinationWKKESNKKFKADATE
CCHHCCCCCCCHHHH		57.2417644757
1343UbiquitinationKESNKKFKADATEQL
HHCCCCCCCHHHHHH		54.9917644757
1351UbiquitinationADATEQLKEWALNSL
CHHHHHHHHHHHHHH		51.4023749301
1357PhosphorylationLKEWALNSLASKVLD
HHHHHHHHHHHHHCC		26.6021440633
1360PhosphorylationWALNSLASKVLDDKE
HHHHHHHHHHCCCHH		28.7021440633
1361UbiquitinationALNSLASKVLDDKEM
HHHHHHHHHCCCHHH		41.0117644757
1366UbiquitinationASKVLDDKEMIKSEI
HHHHCCCHHHHHHHC		49.1821427232
1401UbiquitinationKTVTNRNKWSMLKRI
CCCCCCCHHHHHHHH		37.0922817900
1406UbiquitinationRNKWSMLKRICYLQY
CCHHHHHHHHHHHHH		30.9522817900
1437PhosphorylationKDMRRHLSSSTESTR
HHHHHHHHCCCCCCC		19.0023749301
1438PhosphorylationDMRRHLSSSTESTRN
HHHHHHHCCCCCCCC		47.8727214570
1439PhosphorylationMRRHLSSSTESTRNG
HHHHHHCCCCCCCCC		32.5828889911
1440PhosphorylationRRHLSSSTESTRNGS
HHHHHCCCCCCCCCC		35.5819779198
1442PhosphorylationHLSSSTESTRNGSNS
HHHCCCCCCCCCCCC		32.5227214570
1443PhosphorylationLSSSTESTRNGSNSL
HHCCCCCCCCCCCCC		23.1727214570
1447PhosphorylationTESTRNGSNSLPLNE
CCCCCCCCCCCCCCC		27.1322369663
1449PhosphorylationSTRNGSNSLPLNEKS
CCCCCCCCCCCCCCC		32.8222369663
1455UbiquitinationNSLPLNEKSNEGEST
CCCCCCCCCCCCCCC		58.4723749301
1456PhosphorylationSLPLNEKSNEGESTN
CCCCCCCCCCCCCCC		33.6622369663
1461PhosphorylationEKSNEGESTNVDQDI
CCCCCCCCCCCCCCC		35.8222369663
1462PhosphorylationKSNEGESTNVDQDIE
CCCCCCCCCCCCCCC		34.6522369663
1482UbiquitinationRLHEDILKNQELDDG
HHHHHHHHCCCCCCC		57.8524961812
1501UbiquitinationLLSQIIPKITNFNSG
HHHHHHHHHHCCCCC		52.3217644757
1514UbiquitinationSGEIDDAKKEELLKL
CCCCCHHHHHHHHHC		68.6517644757
1515UbiquitinationGEIDDAKKEELLKLN
CCCCHHHHHHHHHCC		59.1317644757
1520UbiquitinationAKKEELLKLNFIDPY
HHHHHHHHCCCCCCC		54.7517644757
1622UbiquitinationKAAELRMKLSGSLLY
HHHHHHHHHHHHHHH		32.8217644757
1626PhosphorylationLRMKLSGSLLYGFNQ
HHHHHHHHHHHHCCH		16.3030377154
1634UbiquitinationLLYGFNQKVFDKHTA
HHHHCCHHHCCHHHH		46.0717644757
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SPO14_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SPO14_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SPO14_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SEC14_YEASTSEC14genetic
11973292
SEC14_YEASTSEC14genetic
15560781
KICH_YEASTCKI1genetic
15560781
SSP2_YEASTSSP2physical
17110477
OSW1_YEASTOSW1physical
17110477
SMA1_YEASTSMA1physical
16148007
VPS64_YEASTVPS64genetic
20526336
VPS5_YEASTVPS5genetic
20526336
SWA2_YEASTSWA2genetic
20526336
CSR1_YEASTCSR1genetic
15560781
RPB4_YEASTRPB4genetic
21954159
SPC72_YEASTSPC72physical
22875988
ARE1_YEASTARE1physical
22875988
SEC9_YEASTSEC9physical
22875988
ETP1_YEASTETP1physical
22875988
PLMT_YEASTOPI3genetic
23891562
PSD1_YEASTPSD1genetic
23891562
GET2_YEASTGET2genetic
23891562
SRO7_YEASTSRO7genetic
23891562
MSMO_YEASTERG25genetic
23891562
ERG3_YEASTERG3genetic
23891562
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SPO14_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-30; SER-1268 ANDSER-1447, AND MASS SPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1268, AND MASSSPECTROMETRY.

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