ARE1_YEAST - dbPTM
ARE1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ARE1_YEAST
UniProt AC P25628
Protein Name Sterol O-acyltransferase 1
Gene Name ARE1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 610
Subcellular Localization Endoplasmic reticulum membrane
Multi-pass membrane protein.
Protein Description
Protein Sequence MTETKDLLQDEEFLKIRRLNSAEANKRHSVTYDNVILPQESMEVSPRSSTTSLVEPVESTEGVESTEAERVAGKQEQEEEYPVDAHMQKYLSHLKSKSRSRFHRKDASKYVSFFGDVSFDPRPTLLDSAINVPFQTTFKGPVLEKQLKNLQLTKTKTKATVKTTVKTTEKTDKADAPPGEKLESNFSGIYVFAWMFLGWIAIRCCTDYYASYGSAWNKLEIVQYMTTDLFTIAMLDLAMFLCTFFVVFVHWLVKKRIINWKWTGFVAVSIFELAFIPVTFPIYVYYFDFNWVTRIFLFLHSVVFVMKSHSFAFYNGYLWDIKQELEYSSKQLQKYKESLSPETREILQKSCDFCLFELNYQTKDNDFPNNISCSNFFMFCLFPVLVYQINYPRTSRIRWRYVLEKVCAIIGTIFLMMVTAQFFMHPVAMRCIQFHNTPTFGGWIPATQEWFHLLFDMIPGFTVLYMLTFYMIWDALLNCVAELTRFADRYFYGDWWNCVSFEEFSRIWNVPVHKFLLRHVYHSSMGALHLSKSQATLFTFFLSAVFHEMAMFAIFRRVRGYLFMFQLSQFVWTALSNTKFLRARPQLSNVVFSFGVCSGPSIIMTLYLTL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
21PhosphorylationLKIRRLNSAEANKRH
HHHHCCCCHHHHHCC		31.8825521595
29PhosphorylationAEANKRHSVTYDNVI
HHHHHCCCCEECCEE		21.8628889911
31PhosphorylationANKRHSVTYDNVILP
HHHCCCCEECCEEEC		28.3326447709
32PhosphorylationNKRHSVTYDNVILPQ
HHCCCCEECCEEECH		11.9019779198
41PhosphorylationNVILPQESMEVSPRS
CEEECHHHCCCCCCC		18.2622369663
45PhosphorylationPQESMEVSPRSSTTS
CHHHCCCCCCCCCCC		10.9922369663
48PhosphorylationSMEVSPRSSTTSLVE
HCCCCCCCCCCCCEE		35.1122369663
49PhosphorylationMEVSPRSSTTSLVEP
CCCCCCCCCCCCEEC		36.6623749301
50PhosphorylationEVSPRSSTTSLVEPV
CCCCCCCCCCCEECC		22.9622369663
51PhosphorylationVSPRSSTTSLVEPVE
CCCCCCCCCCEECCC		23.2423749301
52PhosphorylationSPRSSTTSLVEPVES
CCCCCCCCCEECCCC		30.4222369663
209PhosphorylationIRCCTDYYASYGSAW
HHHHHHHHHHCCHHH		7.5927738172
211PhosphorylationCCTDYYASYGSAWNK
HHHHHHHHCCHHHHH		17.5727738172
214PhosphorylationDYYASYGSAWNKLEI
HHHHHCCHHHHHHHH		23.1327738172
514AcetylationIWNVPVHKFLLRHVY
HHCCCHHHHHHHHHH		37.6324489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ARE1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ARE1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ARE1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ARE2_YEASTARE2genetic
8650549
ARE2_YEASTARE2genetic
10672016
ARV1_YEASTARV1genetic
11063737
ARE2_YEASTARE2genetic
11741946
DGAT2_YEASTDGA1genetic
11741946
PDAT_YEASTLRO1genetic
11741946
CHO2_YEASTCHO2genetic
16269340
OST5_YEASTOST5genetic
16269340
ARV1_YEASTARV1genetic
16269340
IZH4_YEASTIZH4genetic
16269340
PMA1_YEASTPMA1genetic
16269340
ARE2_YEASTARE2genetic
19608739
DGAT2_YEASTDGA1genetic
19608739
PDAT_YEASTLRO1genetic
19608739
ARE2_YEASTARE2genetic
19690167
DGAT2_YEASTDGA1genetic
19690167
PDAT_YEASTLRO1genetic
19690167
CHO2_YEASTCHO2genetic
19690167
RIC1_YEASTRIC1genetic
20526336
PAH1_YEASTPAH1genetic
21422231
PDX3_YEASTPDX3genetic
21623372
IPT1_YEASTIPT1genetic
21623372
FOLE_YEASTMET7genetic
21623372
SKN1_YEASTSKN1genetic
21623372
SPEE_YEASTSPE3genetic
21623372
UGA4_YEASTUGA4genetic
21623372
GAL2_YEASTGAL2genetic
21623372
SYSM_YEASTDIA4genetic
21623372
ATP14_YEASTATP14genetic
21623372
CBS_YEASTCYS4genetic
21623372
ARE2_YEASTARE2genetic
21693588
DGAT2_YEASTDGA1genetic
21693588
PDAT_YEASTLRO1genetic
21693588
PDAT_YEASTLRO1genetic
22738231
ARE2_YEASTARE2genetic
22738231
DGAT2_YEASTDGA1genetic
22738231
DOA10_YEASTSSM4genetic
23898401
ARE2_YEASTARE2genetic
23898401
UBC7_YEASTUBC7genetic
23898401
BAP3_YEASTBAP3genetic
27708008
SKN1_YEASTSKN1genetic
27708008
SUR7_YEASTSUR7genetic
27708008
AIM39_YEASTAIM39genetic
27708008
MKK2_YEASTMKK2genetic
27708008
CGS5_YEASTCLB5genetic
27708008
LTE1_YEASTLTE1genetic
27708008
NCL1_YEASTNCL1genetic
27708008
YPQ3_YEASTRTC2genetic
27708008
AIM4_YEASTAIM4genetic
27708008
GPR1_YEASTGPR1genetic
27708008
MRH1_YEASTMRH1genetic
27708008
RAD4_YEASTRAD4genetic
27708008
HSP12_YEASTHSP12genetic
27708008
SA155_YEASTSAP155genetic
27708008
RAD54_YEASTRAD54genetic
27708008
HFM1_YEASTHFM1genetic
27708008
MUP1_YEASTMUP1genetic
27708008
YG3A_YEASTYGR130Cgenetic
27708008
RL24B_YEASTRPL24Bgenetic
27708008
CHO2_YEASTCHO2genetic
27708008
TBP7_YEASTYTA7genetic
27708008
YKZ5_YEASTYKR015Cgenetic
27708008
SUMT_YEASTMET1genetic
27708008
BPT1_YEASTBPT1genetic
27708008
ARV1_YEASTARV1genetic
27708008
YL287_YEASTYLR287Cgenetic
27708008
RAD52_YEASTRAD52genetic
27708008
PRM6_YEASTPRM6genetic
27708008
YML9_YEASTYML119Wgenetic
27708008
IRC21_YEASTIRC21genetic
27708008
YM59_YEASTYMR209Cgenetic
27708008
TMA23_YEASTTMA23genetic
27708008
FAP1_YEASTFAP1genetic
27708008
EOS1_YEASTEOS1genetic
27708008
ADE_YEASTAAH1genetic
27708008
YNO4_YEASTYNL144Cgenetic
27708008
PEX15_YEASTPEX15genetic
27708008
MET22_YEASTMET22genetic
27708008
RRP6_YEASTRRP6genetic
27708008
ATX2_YEASTATX2genetic
27708008
LEO1_YEASTLEO1genetic
27708008
KIN4_YEASTKIN4genetic
27708008
RDL1_YEASTRDL1genetic
27708008
MUM3_YEASTMUM3genetic
27708008
SVL3_YEASTSVL3genetic
27708008
PMA2_YEASTPMA2genetic
27708008
CWC27_YEASTCWC27genetic
27708008
RL21B_YEASTRPL21Bgenetic
27708008
DBP1_YEASTDBP1genetic
27708008
H1_YEASTHHO1genetic
27708008
TGS1_YEASTTGS1genetic
27708008
RU2A_YEASTLEA1genetic
27708008
THP3_YEASTTHP3genetic
27708008
NAA30_YEASTMAK3genetic
27708008
BRR1_YEASTBRR1genetic
27708008
CHMU_YEASTARO7genetic
27708008
SPEE_YEASTSPE3genetic
27708008
PHSG_YEASTGPH1genetic
27708008
DGAT2_YEASTDGA1genetic
26432634
PDAT_YEASTLRO1genetic
26432634
PCY1_YEASTPCT1genetic
26269581
DGK1_YEASTDGK1genetic
26269581
DGAT2_YEASTDGA1genetic
27170177
PDAT_YEASTLRO1genetic
27170177
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ARE1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45 AND SER-48, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21 AND SER-45, AND MASSSPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45, AND MASSSPECTROMETRY.

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