ADE_YEAST - dbPTM
ADE_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ADE_YEAST
UniProt AC P53909
Protein Name Adenine deaminase {ECO:0000255|HAMAP-Rule:MF_03145}
Gene Name AAH1 {ECO:0000255|HAMAP-Rule:MF_03145}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 347
Subcellular Localization Cytoplasm . Nucleus .
Protein Description Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. Also exhibits a low activity towards N(6)-substituted adenines that are commonly known as the plant hormones cytokinins..
Protein Sequence MVSVEFLQELPKCEHHLHLEGTLEPDLLFPLAKRNDIILPEGFPKSVEELNEKYKKFRDLQDFLDYYYIGTNVLISEQDFFDLAWAYFKKVHKQGLVHAEVFYDPQSHTSRGISIETVTKGFQRACDKAFSEFGITSKLIMCLLRHIEPEECLKTIEEATPFIKDGTISALGLDSAEKPFPPHLFVECYGKAASLNKDLKLTAHAGEEGPAQFVSDALDLLQVTRIDHGINSQYDEELLDRLSRDQTMLTICPLSNVKLQVVQSVSELPLQKFLDRDVPFSLNSDDPAYFGGYILDVYTQVSKDFPHWDHETWGRIAKNAIKGSWCDDKRKNGLLSRVDEVVTKYSH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
12UbiquitinationEFLQELPKCEHHLHL
HHHHHCCCCCCEEEC		65.9515699485
33UbiquitinationDLLFPLAKRNDIILP
HHHHHHHHCCCEECC		60.4617644757
45UbiquitinationILPEGFPKSVEELNE
ECCCCCCCCHHHHHH		65.9417644757
93UbiquitinationAYFKKVHKQGLVHAE
HHHHHHHHCCCEEEE		49.3917644757
107PhosphorylationEVFYDPQSHTSRGIS
EEEECCCCCCCCCEE		33.8319823750
109PhosphorylationFYDPQSHTSRGISIE
EECCCCCCCCCEEHH		25.9319823750
110PhosphorylationYDPQSHTSRGISIET
ECCCCCCCCCEEHHH		24.0819823750
114PhosphorylationSHTSRGISIETVTKG
CCCCCCEEHHHHHHH		19.7319823750
117PhosphorylationSRGISIETVTKGFQR
CCCEEHHHHHHHHHH		31.6319823750
120UbiquitinationISIETVTKGFQRACD
EEHHHHHHHHHHHHH		54.0815699485
128AcetylationGFQRACDKAFSEFGI
HHHHHHHHHHHHHCH		51.7424489116
128UbiquitinationGFQRACDKAFSEFGI
HHHHHHHHHHHHHCH		51.7417644757
138UbiquitinationSEFGITSKLIMCLLR
HHHCHHHHHHHHHHH		33.1217644757
154UbiquitinationIEPEECLKTIEEATP
CCHHHHHHHHHHHCC		60.1524961812
164UbiquitinationEEATPFIKDGTISAL
HHHCCCCCCCCEEEC		50.9517644757
178UbiquitinationLGLDSAEKPFPPHLF
CCCCCCCCCCCCCEE		52.2317644757
191UbiquitinationLFVECYGKAASLNKD
EEEEEECHHHHCCCC		17.8217644757
197UbiquitinationGKAASLNKDLKLTAH
CHHHHCCCCCCEEEC		70.5015699485
200UbiquitinationASLNKDLKLTAHAGE
HHCCCCCCEEECCCC		54.6617644757
258UbiquitinationICPLSNVKLQVVQSV
EECCCCCEEEEEECH		37.1417644757
272UbiquitinationVSELPLQKFLDRDVP
HHHCCHHHHHCCCCC		56.4224961812
303UbiquitinationDVYTQVSKDFPHWDH
EEEEEECCCCCCCCH		65.6117644757
329UbiquitinationKGSWCDDKRKNGLLS
CCCCCCHHHHCCCHH		52.6123749301
331UbiquitinationSWCDDKRKNGLLSRV
CCCCHHHHCCCHHHH		62.1922817900
344UbiquitinationRVDEVVTKYSH----
HHHHHHHHCCC----		32.9015699485
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseSAF1P38352
PMID:22199232
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ADE_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ADE_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ADE_YEASTAAH1physical
14759368
APT1_YEASTAPT1genetic
16941010
APT2_YEASTAPT2genetic
16941010
ADK_YEASTADO1genetic
16941010
SAF1_YEASTSAF1physical
17517885
VIP1_YEASTVIP1genetic
28520786
RL36B_YEASTRPL36Bgenetic
28520786
PHO4_YEASTPHO4genetic
28520786
TMA23_YEASTTMA23genetic
28520786
BUD31_YEASTBUD31genetic
28520786
PHO81_YEASTPHO81genetic
28520786
YG188_YEASTYGL188C-Agenetic
28520786
RS17A_YEASTRPS17Agenetic
28520786
ACON2_YEASTACO2genetic
28520786
TUP1_YEASTTUP1genetic
28520786
THP3_YEASTTHP3genetic
28520786
UBP4_YEASTDOA4genetic
28520786
BRO1_YEASTBRO1genetic
28520786
RS8A_YEASTRPS8Agenetic
28520786
RS8B_YEASTRPS8Agenetic
28520786
RLA4_YEASTRPP2Bgenetic
28520786
RL19A_YEASTRPL19Bgenetic
28520786
RL19B_YEASTRPL19Bgenetic
28520786
NSR1_YEASTNSR1genetic
28520786
ARP8_YEASTARP8genetic
28520786
GSH1_YEASTGSH1genetic
28520786
MRT4_YEASTMRT4genetic
28520786
PIH1_YEASTPIH1genetic
28520786
IPT1_YEASTIPT1genetic
28520786
ELP6_YEASTELP6genetic
28520786
RS10A_YEASTRPS10Agenetic
28520786
ADA2_YEASTADA2genetic
28520786
RSA1_YEASTRSA1genetic
28520786
GCN4_YEASTGCN4genetic
28520786
AROC_YEASTARO2genetic
28520786
RPC8_YEASTRPC25genetic
28520786
SSF1_YEASTSSF1genetic
28520786
RL22A_YEASTRPL22Agenetic
28520786
ARO1_YEASTARO1genetic
28520786
ARGJ_YEASTARG7genetic
28520786
BUD23_YEASTBUD23genetic
28520786
RS7A_YEASTRPS7Agenetic
28520786
DPH3_YEASTKTI11genetic
28520786
TKT1_YEASTTKL1genetic
28520786
RL6B_YEASTRPL6Bgenetic
28520786
BUD27_YEASTBUD27genetic
28520786
WHI5_YEASTWHI5genetic
28520786
SKI3_YEASTSKI3genetic
28520786
HSC82_YEASTHSC82genetic
28520786
IF6_YEASTTIF6genetic
28520786
LDB16_YEASTLDB16genetic
28520786
RL26B_YEASTRPL26Bgenetic
28520786
YM242_YEASTYMR242W-Agenetic
28520786
SCW10_YEASTSCW10genetic
28520786
THO2_YEASTTHO2genetic
28520786
FABD_YEASTMCT1genetic
28520786
SGF29_YEASTSGF29genetic
28520786
POC3_YEASTIRC25genetic
28520786
DLDH_YEASTLPD1genetic
28520786
NAA30_YEASTMAK3genetic
28520786
DBP3_YEASTDBP3genetic
28520786
SPB4_YEASTSPB4genetic
28520786
SPT4_YEASTSPT4genetic
28520786
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ADE_YEAST

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory