| UniProt ID | SPB4_YEAST | |
|---|---|---|
| UniProt AC | P25808 | |
| Protein Name | ATP-dependent rRNA helicase SPB4 {ECO:0000305} | |
| Gene Name | SPB4 {ECO:0000303|PubMed:2408148} | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 606 | |
| Subcellular Localization | Nucleus, nucleolus . | |
| Protein Description | ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. [PubMed: 2408148] | |
| Protein Sequence | MSKSLEWDNLGFSLLPWIRTGLDVMGFETMTPVQASTIPMLAGNKDVVVDSVTGSGKTAAFVIPVLEKVVKEEANTSKFKKAHFHSLIIAPTRELSRQIESVVLSFLEHYPSDLFPIKCQLLVGTNEATVRDDVSNFLRNRPQILIGTPGRVLDFLQMPAVKTSACSMVVMDEADRLLDMSFIKDTEKILRLLPKQRRTGLFSATMRSAGSDIFKTGLRNPVRITVNSKNQAPSSLKLNYCVVNPAEKLQLLVSILNNYKFKKCIVYFPTCVSVSYFYSFIQYLGKRNILVNEVEIFSLHGKLQTSARTKTLTAFTDSLSNSVLFTTDVAARGIDIPDVDLVIQLDPPTNTDMFMHRCGRTGRANRVGKAITFLNEGREEDFIPFMQVKNVELEELDLEVKGITTNFYEDFRNWILEDRDRFDKGVKAYVAFIKYYSNHSATSIFRLQSLDYVGIAKLYGLFRLPRMPEITKYLATEKQEGIFPGNWLVDPPVNMDEYKYKDKKREKERQETLKNISLINDKKKLKSELKKKNLAWSDKTLTKERKLERKEKMSLKRKAIEEELKAEELDENAEEERIKEDWKEIVLQNKRKKVSSKAIQGNFDDL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 68 | Acetylation | FVIPVLEKVVKEEAN EHHHHHHHHHHHHHC | 48.44 | 24489116 | |
| 199 | Phosphorylation | LLPKQRRTGLFSATM HCCCCCHHCCCHHHH | 40.19 | 26447709 | |
| 203 | Phosphorylation | QRRTGLFSATMRSAG CCHHCCCHHHHHHCC | 28.07 | 26447709 | |
| 205 | Phosphorylation | RTGLFSATMRSAGSD HHCCCHHHHHHCCCC | 16.36 | 26447709 | |
| 208 | Phosphorylation | LFSATMRSAGSDIFK CCHHHHHHCCCCHHH | 26.59 | 26447709 | |
| 211 | Phosphorylation | ATMRSAGSDIFKTGL HHHHHCCCCHHHCCC | 27.52 | 27214570 | |
| 254 | Phosphorylation | EKLQLLVSILNNYKF HHHHHHHHHHHCCCC | 22.71 | 17287358 | |
| 539 | Acetylation | KNLAWSDKTLTKERK CCCCCCCCCCCHHHH | 39.66 | 24489116 | |
| 597 | Acetylation | KRKKVSSKAIQGNFD CCHHHCHHHHCCCCC | 41.84 | 22865919 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SPB4_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SPB4_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SPB4_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-254, AND MASSSPECTROMETRY. | |
