dbPTM

CSH1_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CSH1_YEAST
UniProt AC	P38287
Protein Name	Mannosyl phosphorylinositol ceramide synthase CSH1
Gene Name	CSH1
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	376
Subcellular Localization	Vacuole membrane Multi-pass membrane protein .
Protein Description	Involved in the synthesis of mannosyl phosphorylinositol ceramide. Catalyzes the addition of mannosyl to phosphorylinositol ceramide..
Protein Sequence	MKKELKILIIANIALLISIIHYTFDLLTLCIDDTSKDALTDEQLNPPNGFNSTFYESPPQLIPKIIHQTYKTNDIPEQWVKGRQKCIDLHPDYTYILWTDEMSDTFIKQEYPWFLDTFRSYEYPIERADAIRYFILSHYGGIYIDLDDGCERRLDPLLKVPAFLRKTSPTGVSNDVMGSVPRHPFFLKVIKSLKHYKKNWYIPYMTIMGSTGPLFISVVWKQYKRWSNTAENGAVRILQPADYKMHNNSFFSISKGSSWHTGDANFMKTLENHILSCVVTGFIFGFFILYGEFTFYTWLCSGPFNNKRYYIQWLSDKFKLHKWKLTSSYKNKEKRRNPTRHEYNSRGKRLRKDSNIPYDSVFLDIEKNHAKFTDLT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
166	Ubiquitination	KVPAFLRKTSPTGVS CCCCHHHCCCCCCCC	56.34	23749301
330	Ubiquitination	WKLTSSYKNKEKRRN CCCCHHCCCHHHHCC	64.59	23749301
354	Phosphorylation	GKRLRKDSNIPYDSV CCHHCCCCCCCCCEE	39.43	17330950
371	Ubiquitination	DIEKNHAKFTDLT-- EHHHHCCCCCCCC--	41.04	23749301

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CSH1_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CSH1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CSH1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CSG2_YEAST	CSG2	physical	12954640
SUR1_YEAST	SUR1	genetic	12954640
HOR7_YEAST	HOR7	genetic	15208314
GDA1_YEAST	GDA1	physical	16093310
AVT1_YEAST	AVT1	physical	16093310
FTH1_YEAST	FTH1	genetic	20526336
SUR1_YEAST	SUR1	genetic	20526336
SUR1_YEAST	SUR1	genetic	21623372
THDH_YEAST	ILV1	genetic	21623372
QCR7_YEAST	QCR7	genetic	21623372
ATPF_YEAST	ATP4	genetic	21623372
COQ7_YEAST	CAT5	genetic	21623372
SUR1_YEAST	SUR1	genetic	23891562
MNN11_YEAST	MNN11	genetic	25471153
KTR6_YEAST	KTR6	genetic	25471153
VPS74_YEAST	VPS74	genetic	25471153
PDR12_YEAST	PDR12	genetic	25471153
VPS1_YEAST	VPS1	genetic	25471153
VPS9_YEAST	VPS9	genetic	25471153
ODPB_YEAST	PDB1	genetic	25471153
ODP2_YEAST	LAT1	genetic	25471153
DLDH_YEAST	LPD1	genetic	25471153
MPC1_YEAST	MPC1	genetic	25471153
TOS1_YEAST	TOS1	genetic	25471153
SAC1_YEAST	SAC1	genetic	25471153
GCSH_YEAST	GCV3	genetic	25471153
MNL2_YEAST	MNL2	genetic	25471153
SYS1_YEAST	SYS1	genetic	25471153
OCH1_YEAST	OCH1	genetic	25471153
MNN2_YEAST	MNN2	genetic	25471153
MNN9_YEAST	MNN9	genetic	25471153
SLT2_YEAST	SLT2	genetic	25471153
RLM1_YEAST	RLM1	genetic	25471153
SUR2_YEAST	SUR2	genetic	23692275
SUR2_YEAST	SUR2	genetic	26404656
SCS7_YEAST	SCS7	genetic	26404656
BLM10_YEAST	BLM10	genetic	27708008
CWH41_YEAST	CWH41	genetic	27708008
IXR1_YEAST	IXR1	genetic	27708008
GBLP_YEAST	ASC1	genetic	27708008
PMT2_YEAST	PMT2	genetic	27708008
SWD1_YEAST	SWD1	genetic	27708008
GAL7_YEAST	GAL7	genetic	27708008
STDH_YEAST	CHA1	genetic	27708008
CWH43_YEAST	CWH43	genetic	27708008
PAT1_YEAST	PAT1	genetic	27708008
NHP10_YEAST	NHP10	genetic	27708008
BDF2_YEAST	BDF2	genetic	27708008
VAM6_YEAST	VAM6	genetic	27708008
FADH_YEAST	SFA1	genetic	27708008
YD061_YEAST	YDR061W	genetic	27708008
OCA6_YEAST	OCA6	genetic	27708008
IPT1_YEAST	IPT1	genetic	27708008
AFR1_YEAST	AFR1	genetic	27708008
GIS1_YEAST	GIS1	genetic	27708008
ECM18_YEAST	ECM18	genetic	27708008
ARO1_YEAST	ARO1	genetic	27708008
YD131_YEAST	YDR131C	genetic	27708008
CSN9_YEAST	CSN9	genetic	27708008
YPQ2_YEAST	YPQ2	genetic	27708008
LCMT1_YEAST	PPM1	genetic	27708008
SDC1_YEAST	SDC1	genetic	27708008
IES5_YEAST	IES5	genetic	27708008
BEM2_YEAST	BEM2	genetic	27708008
BCK2_YEAST	BCK2	genetic	27708008
IES1_YEAST	IES1	genetic	27708008
KA122_YEAST	KAP122	genetic	27708008
CSK2B_YEAST	CKB1	genetic	27708008
CGR1_YEAST	CGR1	genetic	27708008
MON1_YEAST	MON1	genetic	27708008
MRM2_YEAST	MRM2	genetic	27708008
MED5_YEAST	NUT1	genetic	27708008
HUR1_YEAST	HUR1	genetic	27708008
RTF1_YEAST	RTF1	genetic	27708008
COS12_YEAST	COS12	genetic	27708008
EFM5_YEAST	AML1	genetic	27708008
PEX31_YEAST	PEX31	genetic	27708008
MTL1_YEAST	MTL1	genetic	27708008
KSP1_YEAST	KSP1	genetic	27708008
ARP1_YEAST	ARP1	genetic	27708008
DOA10_YEAST	SSM4	genetic	27708008
REV7_YEAST	REV7	genetic	27708008
LSM1_YEAST	LSM1	genetic	27708008
MRS3_YEAST	MRS3	genetic	27708008
KAPA_YEAST	TPK1	genetic	27708008
HOC1_YEAST	HOC1	genetic	27708008
HIR3_YEAST	HIR3	genetic	27708008
UFD4_YEAST	UFD4	genetic	27708008
MNR2_YEAST	MNR2	genetic	27708008
YKH5_YEAST	YKL075C	genetic	27708008
HSL1_YEAST	HSL1	genetic	27708008
DGR2_YEAST	DGR2	genetic	27708008
CTK1_YEAST	CTK1	genetic	27708008
NNRD_YEAST	YKL151C	genetic	27708008
KAPC_YEAST	TPK3	genetic	27708008
KKQ8_YEAST	KKQ8	genetic	27708008
LST4_YEAST	LST4	genetic	27708008
DYHC_YEAST	DYN1	genetic	27708008
RHO4_YEAST	RHO4	genetic	27708008
MSA2_YEAST	MSA2	genetic	27708008
RT109_YEAST	RTT109	genetic	27708008
LDB18_YEAST	LDB18	genetic	27708008
YL012_YEAST	YLR012C	genetic	27708008
BRE2_YEAST	BRE2	genetic	27708008
YL177_YEAST	YLR177W	genetic	27708008
VTA1_YEAST	VTA1	genetic	27708008
ROM2_YEAST	ROM2	genetic	27708008
CDC73_YEAST	CDC73	genetic	27708008
PSP2_YEAST	PSP2	genetic	27708008
YM22_YEAST	YMR144W	genetic	27708008
ZRC1_YEAST	ZRC1	genetic	27708008
DYN3_YEAST	DYN3	genetic	27708008
NST1_YEAST	NST1	genetic	27708008
YN87_YEAST	YNR014W	genetic	27708008
NOP12_YEAST	NOP12	genetic	27708008
ALG6_YEAST	ALG6	genetic	27708008
YO059_YEAST	LPL1	genetic	27708008
ALG8_YEAST	ALG8	genetic	27708008
DIA2_YEAST	DIA2	genetic	27708008
LPX1_YEAST	LPX1	genetic	27708008
YOR97_YEAST	YOR097C	genetic	27708008
RUD3_YEAST	RUD3	genetic	27708008
ATF1_YEAST	ATF1	genetic	27708008
SUR1_YEAST	SUR1	genetic	27708008
GGPPS_YEAST	BTS1	genetic	27708008
RNY1_YEAST	RNY1	genetic	27708008
BRR1_YEAST	BRR1	genetic	27708008
MED1_YEAST	MED1	genetic	27708008
DBF20_YEAST	DBF20	genetic	27708008
HDA3_YEAST	HDA3	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CSH1_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-354, AND MASSSPECTROMETRY.	17330950 [Abstract]