MNN9_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MNN9_YEAST
• UniProt AC: P39107
• Protein Name: Mannan polymerase complexes subunit MNN9
• Gene Name: MNN9
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 395
• Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass type II membrane protein . Golgi apparatus membrane ; Single-pass type II membrane protein . Cis-Golgi (PubMed:9430634). Recycles between endoplasmic reticulum and Golgi (PubMed:11095735).
• Protein Description: The M-Pol I and M-Pol II complexes possess alpha-1,6-mannosyltransferase activity and are probably involved in the elongation of the mannan backbone of N-linked glycans on cell wall and periplasmic proteins. May also provide alpha-1,2-mannosyltransferase activity to the M-Pol I complex..
• Protein Sequence: MSLSLVSYRLRKNPWVNIFLPVLAIFLIYIIFFQRDQSLLGLNGQSISQHKWAHEKENTFYFPFTKKYKMPKYSYKKKSGWLFNDHVEDIIPEGHIAHYDLNKLHSTSEAAVNKEHILILTPMQTFHQQYWDNLLQLNYPRELIELGFITPRTATGDLALKKLENAIKKVQTDKKTQRFSKITILRQNSQSFDKLMEKERHALDVQKERRAAMALARNELLFSTIGPHTSWVLWLDADIIETPPSLIQDMTKHNKAILAANIYQRFYDEEKKQPSIRPYDFNNWQESDTGLEIASQMGDDEIIVEGYAEIATYRPLMAHFYDANGVPGEEMALDGVGGGCTLVKAEVHRDGAMFPNFPFYHLIETEGFAKMAKRLNYDVFGLPNYLVYHIEEENH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
56	Acetylation	QHKWAHEKENTFYFP CCCCCHHCCCCEEEC	46.53	24489116
66	Acetylation	TFYFPFTKKYKMPKY CEEECCCCCCCCCCC	55.26	24489116
78	Ubiquitination	PKYSYKKKSGWLFND CCCCCCCCCCCCCCC	50.47	17644757
103	Ubiquitination	IAHYDLNKLHSTSEA EEEEEHHHCCCCCCH	55.67	17644757
155	Phosphorylation	FITPRTATGDLALKK CCCCCCCCCHHHHHH	30.53	28889911
198	Ubiquitination	SFDKLMEKERHALDV HHHHHHHHHHHHHHH	46.19	17644757
207	Ubiquitination	RHALDVQKERRAAMA HHHHHHHHHHHHHHH	53.70	17644757
255	Ubiquitination	QDMTKHNKAILAANI HHHHHHCHHHHHHHH	36.20	17644757
373	Ubiquitination	EGFAKMAKRLNYDVF HHHHHHHHHCCCEEC	54.65	17644757

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MNN9_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MNN9_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MNN9_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VAN1_YEAST	VAN1	physical	9756928
VAN1_YEAST	VAN1	physical	9434768
ANP1_YEAST	ANP1	physical	9434768
VAN1_YEAST	VAN1	physical	9430634
VAN1_YEAST	VAN1	physical	10037752
ANP1_YEAST	ANP1	physical	9430634
ANP1_YEAST	ANP1	physical	10037752
HOC1_YEAST	HOC1	physical	9430634
HOC1_YEAST	HOC1	physical	10037752
MNN11_YEAST	MNN11	physical	9430634
MNN11_YEAST	MNN11	physical	10037752
HOC1_YEAST	HOC1	physical	9434768
MNN10_YEAST	MNN10	physical	16429126
MNN11_YEAST	MNN11	physical	16429126
SPO14_YEAST	SPO14	physical	16429126
ANP1_YEAST	ANP1	physical	16429126
PHB1_YEAST	PHB1	physical	16429126
PHB2_YEAST	PHB2	physical	16429126
RL4B_YEAST	RPL4B	physical	16429126
ANP1_YEAST	ANP1	physical	10635561
HOC1_YEAST	HOC1	physical	10635561
VAN1_YEAST	VAN1	physical	10635561
VAN1_YEAST	VAN1	physical	19249370
HSP72_YEAST	SSA2	physical	22940862
HSP71_YEAST	SSA1	physical	22940862
MNN10_YEAST	MNN10	physical	22940862
VAN1_YEAST	VAN1	physical	24026536

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.