| UniProt ID | PHB1_YEAST | |
|---|---|---|
| UniProt AC | P40961 | |
| Protein Name | Prohibitin-1 | |
| Gene Name | PHB1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 287 | |
| Subcellular Localization |
Mitochondrion inner membrane Peripheral membrane protein Intermembrane side . |
|
| Protein Description | Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins. Has an antiproliferative activity. Regulates replicative life span.. | |
| Protein Sequence | MSNSAKLIDVITKVALPIGIIASGIQYSMYDVKGGSRGVIFDRINGVKQQVVGEGTHFLVPWLQKAIIYDVRTKPKSIATNTGTKDLQMVSLTLRVLHRPEVLQLPAIYQNLGLDYDERVLPSIGNEVLKSIVAQFDAAELITQREIISQKIRKELSTRANEFGIKLEDVSITHMTFGPEFTKAVEQKQIAQQDAERAKFLVEKAEQERQASVIRAEGEAESAEFISKALAKVGDGLLLIRRLEASKDIAQTLANSSNVVYLPSQHSGGGNSESSGSPNSLLLNIGR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 6 | Acetylation | --MSNSAKLIDVITK --CCCHHHHHHHHHH | 45.88 | 22865919 | |
| 91 | Phosphorylation | TKDLQMVSLTLRVLH CCCHHHEEEEEHHHC | 15.42 | 22369663 | |
| 93 | Phosphorylation | DLQMVSLTLRVLHRP CHHHEEEEEHHHCCH | 12.66 | 22369663 | |
| 183 | Acetylation | TFGPEFTKAVEQKQI ECCHHHHHHHHHHHH | 56.61 | 24489116 | |
| 188 | Ubiquitination | FTKAVEQKQIAQQDA HHHHHHHHHHHHHHH | 30.11 | 23749301 | |
| 204 | Acetylation | RAKFLVEKAEQERQA HHHHHHHHHHHHHHH | 50.14 | 24489116 | |
| 228 | Acetylation | ESAEFISKALAKVGD HHHHHHHHHHHHHCC | 42.47 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PHB1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PHB1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PHB1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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