MEP2_YEAST - dbPTM
MEP2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MEP2_YEAST
UniProt AC P41948
Protein Name Ammonium transporter MEP2
Gene Name MEP2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 499
Subcellular Localization Membrane
Multi-pass membrane protein.
Protein Description Transporter for ammonium (both charged and uncharged NH3 and NH4) to use as a nitrogen source. The affinity of MEP2 is about twenty times higher than that of MEP1. MEP3 has the lowest affinity. Under ammonium limitation acts as an ammonium sensor, generating a signal that leads to pseudohyphal growth..
Protein Sequence MSYNFTGTPTGEGTGGNSLTTDLNTQFDLANMGWIGVASAGVWIMVPGIGLLYSGLSRKKHALSLLWASMMASAVCIFQWFFWGYSLAFSHNTRGNGFIGTLEFFGFRNVLGAPSSVSSLPDILFAVYQGMFAAVTGALMLGGACERARLFPMMVFLFLWMTIVYCPIACWVWNAEGWLVKLGSLDYAGGLCVHLTSGHGGLVYALILGKRNDPVTRKGMPKYKPHSVTSVVLGTVFLWFGWMFFNGGSAGNATIRAWYSIMSTNLAAACGGLTWMVIDYFRCGRKWTTVGLCSGIIAGLVGITPAAGFVPIWSAVVIGVVTGAGCNLAVDLKSLLRIDDGLDCYSIHGVGGCIGSVLTGIFAADYVNATAGSYISPIDGGWINHHYKQVGYQLAGICAALAWTVTVTSILLLTMNAIPFLKLRLSADEEELGTDAAQIGEFTYEESTAYIPEPIRSKTSAQMPPPHENIDDKIVGNTDAEKNSTPSDASSTKNTDHIV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4N-linked_Glycosylation----MSYNFTGTPTG
----CCCCCCCCCCC		22.2411069679
422UbiquitinationMNAIPFLKLRLSADE
HCHHCHHHHHCCCCH		31.7517644757
426PhosphorylationPFLKLRLSADEEELG
CHHHHHCCCCHHHHC		27.5228889911
448PhosphorylationEFTYEESTAYIPEPI
CCEECCCCEECCCCC		27.1028889911
457PhosphorylationYIPEPIRSKTSAQMP
ECCCCCCCCCCCCCC		40.7928747907
458UbiquitinationIPEPIRSKTSAQMPP
CCCCCCCCCCCCCCC		36.3317644757
459PhosphorylationPEPIRSKTSAQMPPP
CCCCCCCCCCCCCCC		30.4627821475
460PhosphorylationEPIRSKTSAQMPPPH
CCCCCCCCCCCCCCC		21.9027821475
473UbiquitinationPHENIDDKIVGNTDA
CCCCCCCCCCCCCCH		35.2317644757
478PhosphorylationDDKIVGNTDAEKNST
CCCCCCCCCHHCCCC		30.5627214570
482UbiquitinationVGNTDAEKNSTPSDA
CCCCCHHCCCCCCCC		58.9023749301
484PhosphorylationNTDAEKNSTPSDASS
CCCHHCCCCCCCCCC		53.4127214570
485PhosphorylationTDAEKNSTPSDASST
CCHHCCCCCCCCCCC		35.8828152593
487PhosphorylationAEKNSTPSDASSTKN
HHCCCCCCCCCCCCC		45.9928152593
490PhosphorylationNSTPSDASSTKNTDH
CCCCCCCCCCCCCCC		43.4628152593
491PhosphorylationSTPSDASSTKNTDHI
CCCCCCCCCCCCCCC		45.1625005228
492PhosphorylationTPSDASSTKNTDHIV
CCCCCCCCCCCCCCC		26.3125005228
493UbiquitinationPSDASSTKNTDHIV-
CCCCCCCCCCCCCC-		60.8517644757
495PhosphorylationDASSTKNTDHIV---
CCCCCCCCCCCC---		30.4327214570
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MEP2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MEP2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MEP2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MSS11_YEASTMSS11genetic
9987114
MEP3_YEASTMEP3genetic
9234685
MEP3_YEASTMEP3genetic
9482721
MEP1_YEASTMEP1genetic
16468990
PHD1_YEASTPHD1genetic
9832522
MGA1_YEASTMGA1genetic
9832522
CDC6_YEASTCDC6genetic
9832522
TEC1_YEASTTEC1genetic
9832522
MSN1_YEASTMSN1genetic
9832522
MSS1_YEASTMSS1genetic
9832522
SKN7_YEASTSKN7genetic
9832522
MSN5_YEASTMSN5genetic
9832522
DOT6_YEASTDOT6genetic
9832522
HMS1_YEASTHMS1genetic
9832522
HMS2_YEASTHMS2genetic
9832522
MEP1_YEASTMEP1genetic
9832522
MSS11_YEASTMSS11genetic
9832522
MEP3_YEASTMEP3genetic
9832522
SSD1_YEASTSSD1genetic
9832522
DAL80_YEASTDAL80genetic
9832522
URE2_YEASTURE2genetic
9832522
MEP2_YEASTMEP2physical
18434596
MEP3_YEASTMEP3genetic
16941010
RAS2_YEASTRAS2genetic
9482721
GPA2_YEASTGPA2genetic
9482721
MSN1_YEASTMSN1genetic
9987114
PFKA1_YEASTPFK1genetic
21623372
ACON2_YEASTACO2genetic
21623372
TAL1_YEASTTAL1genetic
21623372
SYSM_YEASTDIA4genetic
21623372
DCAM_YEASTSPE2genetic
21623372
ORT1_YEASTORT1genetic
21623372
CY1_YEASTCYT1genetic
21623372
FOLE_YEASTMET7genetic
21623372
GPR1_YEASTGPR1genetic
18622617
HACD_YEASTPHS1physical
21912684
ZEO1_YEASTZEO1physical
21912684
HXT2_YEASTHXT2physical
21912684
CBF5_YEASTCBF5physical
21912684
VATE_YEASTVMA4physical
21912684
GUP1_YEASTGUP1physical
21912684
PMT1_YEASTPMT1physical
21912684
VTC1_YEASTVTC1physical
21912684
VTC4_YEASTVTC4physical
21912684
LST4_YEASTLST4genetic
24415948
MEP2_YEASTMEP2physical
27088325
SWC5_YEASTSWC5genetic
27708008
RS29B_YEASTRPS29Bgenetic
27708008
BAP3_YEASTBAP3genetic
27708008
PEX5_YEASTPEX5genetic
27708008
MPCP_YEASTMIR1genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
PUR91_YEASTADE16genetic
27708008
MLH1_YEASTMLH1genetic
27708008
BUD21_YEASTBUD21genetic
27708008
NCBP2_YEASTCBC2genetic
27708008
RU2A_YEASTLEA1genetic
27708008
FCY1_YEASTFCY1genetic
27708008
BOL3_YEASTAIM1genetic
27708008
FMT_YEASTFMT1genetic
27708008
URA7_YEASTURA7genetic
27708008
FUI1_YEASTFUI1genetic
27708008
RS8A_YEASTRPS8Agenetic
27708008
RS8B_YEASTRPS8Agenetic
27708008
SHE3_YEASTSHE3genetic
27708008
RIM1_YEASTRIM1genetic
27708008
SLX5_YEASTSLX5genetic
27708008
PHM6_YEASTPHM6genetic
27708008
IPK1_YEASTIPK1genetic
27708008
MCM21_YEASTMCM21genetic
27708008
HSP31_YEASTHSP31genetic
27708008
RAD54_YEASTRAD54genetic
27708008
RT13_YEASTMRP13genetic
27708008
YG5Q_YEASTYGR273Cgenetic
27708008
PTH_YEASTPTH1genetic
27708008
TED1_YEASTTED1genetic
27708008
EFM4_YEASTEFM4genetic
27708008
SDHX_YEASTYJL045Wgenetic
27708008
3HAO_YEASTBNA1genetic
27708008
CBF1_YEASTCBF1genetic
27708008
RL14A_YEASTRPL14Agenetic
27708008
KDX1_YEASTKDX1genetic
27708008
TPO5_YEASTTPO5genetic
27708008
CAF4_YEASTCAF4genetic
27708008
MTD1_YEASTMTD1genetic
27708008
SIC1_YEASTSIC1genetic
27708008
BUD8_YEASTBUD8genetic
27708008
VPS9_YEASTVPS9genetic
27708008
NDI1_YEASTNDI1genetic
27708008
RE114_YEASTREC114genetic
27708008
NDH1_YEASTNDE1genetic
27708008
YM35_YEASTYMR160Wgenetic
27708008
YM16A_YEASTYMR316C-Agenetic
27708008
YP063_YEASTYPR063Cgenetic
27708008
GPB1_YEASTGPB1genetic
28247024
MEP3_YEASTMEP3genetic
26172854
MEP1_YEASTMEP1genetic
26172854
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MEP2_YEAST

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Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"In vivo N-glycosylation of the mep2 high-affinity ammoniumtransporter of Saccharomyces cerevisiae reveals an extracytosolic N-terminus.";
Marini A.-M., Andre B.;
Mol. Microbiol. 38:552-564(2000).
Cited for: FUNCTION, TOPOLOGY, MUTAGENESIS OF ASN-4; ASN-252; ASN-368 ANDASN-483, AND GLYCOSYLATION AT ASN-4.

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