dbPTM

EFM4_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	EFM4_YEAST
UniProt AC	P40516
Protein Name	Protein-lysine N-methyltransferase EFM4 {ECO:0000255\|HAMAP-Rule:MF_03188, ECO:0000305\|PubMed:25231983}
Gene Name	EFM4 {ECO:0000255\|HAMAP-Rule:MF_03188, ECO:0000303\|PubMed:25231983}
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	257
Subcellular Localization	Cytoplasm .
Protein Description	S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono- and dimethylates elongation factor 1-alpha (TEF1 and TEF2) at 'Lys-316'. May play a role in intracellular transport..
Protein Sequence	MKRSEKKSMSSALKNGIMERTQPEKVVQMQGTADLSTSKLGTKKYWDELYALELENFRRNPQDTGDCWFSDSDAEQKMIDFLVDNIGAYRISENASVVDLGTGNGHMLFELHQTEFQGKLVGIDYSEESVKLASNIAEATGVDNFISFQQADIFSGDWKPGKYDIVLDKGTLDAISLSGMKINGKLDVVDVYAGVVERILKKDGIFLITSCNFTQDELVKIIETDNLKMWKTIKYPVFQFGGVQGATICSVAFVKQN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
72	Phosphorylation	GDCWFSDSDAEQKMI CCCCCCCCHHHHHHH	23749301
171	Phosphorylation	DIVLDKGTLDAISLS EEEECCCCCEEEECC	19823750
176	Phosphorylation	KGTLDAISLSGMKIN CCCCEEEECCCCEEC	19823750
178	Phosphorylation	TLDAISLSGMKINGK CCEEEECCCCEECCE	19823750

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of EFM4_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of EFM4_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of EFM4_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EF1A_YEAST	TEF2	physical	20510667
MGR1_YEAST	MGR1	genetic	27708008
RV167_YEAST	RVS167	genetic	27708008
PHB2_YEAST	PHB2	genetic	27708008
YOR1_YEAST	YOR1	genetic	27708008
PTH_YEAST	PTH1	genetic	27708008
PIR5_YEAST	YJL160C	genetic	27708008
ENV10_YEAST	ENV10	genetic	27708008
UBX2_YEAST	UBX2	genetic	27708008
MSC6_YEAST	MSC6	genetic	27708008
UBA3_YEAST	UBA3	genetic	27708008
MAK5_YEAST	MAK5	genetic	29674565
SSF1_YEAST	SSF1	genetic	29674565
MDM10_YEAST	MDM10	genetic	29674565
TCPZ_YEAST	CCT6	genetic	29674565
MAK16_YEAST	MAK16	genetic	29674565
RFA1_YEAST	RFA1	genetic	29674565
SLX5_YEAST	SLX5	genetic	29674565
DPOD_YEAST	POL3	genetic	29674565
RAD61_YEAST	RAD61	genetic	29674565
TAF12_YEAST	TAF12	genetic	29674565
PRP3_YEAST	PRP3	genetic	29674565
KRE28_YEAST	KRE28	genetic	29674565
KIP3_YEAST	KIP3	genetic	29674565
TIM16_YEAST	PAM16	genetic	29674565
VPS24_YEAST	VPS24	genetic	29674565
FEN1_YEAST	RAD27	genetic	29674565
ORN_YEAST	REX2	genetic	29674565
GSP1_YEAST	GSP1	genetic	29674565
BUB3_YEAST	BUB3	genetic	29674565
PUS1_YEAST	PUS1	genetic	29674565
BRR1_YEAST	BRR1	genetic	29674565
KAR3_YEAST	KAR3	genetic	29674565
HDA3_YEAST	HDA3	genetic	29674565
GLU2A_YEAST	ROT2	genetic	29674565
NUM1_YEAST	NUM1	genetic	29674565
RTG2_YEAST	RTG2	genetic	29674565
RPN10_YEAST	RPN10	genetic	29674565
ELM1_YEAST	ELM1	genetic	29674565
SPA2_YEAST	SPA2	genetic	29674565
YPT7_YEAST	YPT7	genetic	29674565
PSP2_YEAST	PSP2	genetic	29674565
NEW1_YEAST	NEW1	genetic	29674565

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of EFM4_YEAST

Related Literatures of Post-Translational Modification