PSP2_YEAST - dbPTM
PSP2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PSP2_YEAST
UniProt AC P50109
Protein Name Protein PSP2
Gene Name PSP2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 593
Subcellular Localization Cytoplasm .
Protein Description DNA polymerase alpha mutation suppressor. Suppressor of group II intron splicing defects of a mutation in MRS2. May play a role in mitochondrial mRNA splicing..
Protein Sequence MGTNNTSNNNGTTKKMSLEEFLGNDTLGESVWDEEDINLDAISNTTNIDILKQTKAGEHQRDGHQQHPHGGHGPMNRSRFSNAGPFGGGSMGDFANHHHPLQHQQGPPYIVKFSDLPPRFSNFDIEDLFQAKFTKFIKFKLFWEINKNPSISTLKSGSIFDQNFKRDSKVAFVELYTSRDMDKILNYWTTPLKEIYHITTAPAEFEDFKDYSTKVKLLTDPKDDAGKPFITKTQRSKSNPFGSAKPVDTQSKILDIEEKMENLHVEDTTTLRASLIPSSDSMATTATGSKITILKKQTPTEEESHSATPTPKPLSYSEVVERSVVNETSKKGTPLSKLDSPALELQSKPDKSDEFKGGDEQGFEKGGDDKAQLDVSNDKDKGSETDVDKQFTFKNVEREHSMSRTKYNGNHNNNNGNFRGSNRYRGGPNGSSYKGGHNNRGNRGGYRGGSSYNNNNNNTNDNNNNNNNSSSNNNNGSRYHDRQNNEEGLTSDSSLDASGNKKNDFTNSTSNTQQYSIFKPASGFLGQGNNDSIRNNGRGNYNSSGMNGGSRGRGFGRGRGFGRGAYNNRGSRGGRGSSGNYSNYNNRTTDMPL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
147UbiquitinationKLFWEINKNPSISTL
EEEEECCCCCCCEEE		75.7324961812
150PhosphorylationWEINKNPSISTLKSG
EECCCCCCCEEECCC		38.2721440633
152PhosphorylationINKNPSISTLKSGSI
CCCCCCCEEECCCCC		31.8324961812
153PhosphorylationNKNPSISTLKSGSIF
CCCCCCEEECCCCCC		36.2124961812
155UbiquitinationNPSISTLKSGSIFDQ
CCCCEEECCCCCCCC		53.5124961812
178PhosphorylationAFVELYTSRDMDKIL
EEEEEEECCCHHHHH		16.8428889911
183AcetylationYTSRDMDKILNYWTT
EECCCHHHHHHHHCC		42.3224489116
209AcetylationPAEFEDFKDYSTKVK
CCCCCCCCCCCCEEE		68.9924489116
216UbiquitinationKDYSTKVKLLTDPKD
CCCCCEEEECCCCCC		39.0615699485
222AcetylationVKLLTDPKDDAGKPF
EEECCCCCCCCCCCC		71.6724489116
222UbiquitinationVKLLTDPKDDAGKPF
EEECCCCCCCCCCCC		71.6715699485
227UbiquitinationDPKDDAGKPFITKTQ
CCCCCCCCCCCCCCC		38.1815699485
232UbiquitinationAGKPFITKTQRSKSN
CCCCCCCCCCCCCCC		37.5315699485
233PhosphorylationGKPFITKTQRSKSNP
CCCCCCCCCCCCCCC		22.1421551504
236PhosphorylationFITKTQRSKSNPFGS
CCCCCCCCCCCCCCC		30.5322369663
237UbiquitinationITKTQRSKSNPFGSA
CCCCCCCCCCCCCCC		57.3415699485
238PhosphorylationTKTQRSKSNPFGSAK
CCCCCCCCCCCCCCC		51.4822369663
243PhosphorylationSKSNPFGSAKPVDTQ
CCCCCCCCCCCCCCH		33.2320377248
245UbiquitinationSNPFGSAKPVDTQSK
CCCCCCCCCCCCHHH		47.4715699485
249PhosphorylationGSAKPVDTQSKILDI
CCCCCCCCHHHCCCH		34.6721440633
251PhosphorylationAKPVDTQSKILDIEE
CCCCCCHHHCCCHHH		24.6119823750
252UbiquitinationKPVDTQSKILDIEEK
CCCCCHHHCCCHHHH		37.1515699485
281PhosphorylationSLIPSSDSMATTATG
ECCCCCCCCCEECCC		16.5619779198
292PhosphorylationTATGSKITILKKQTP
ECCCCEEEEEECCCC		24.8019779198
296UbiquitinationSKITILKKQTPTEEE
CEEEEEECCCCCCCC		56.8324961812
298PhosphorylationITILKKQTPTEEESH
EEEEECCCCCCCCCC		40.8520377248
300PhosphorylationILKKQTPTEEESHSA
EEECCCCCCCCCCCC		60.4620377248
304PhosphorylationQTPTEEESHSATPTP
CCCCCCCCCCCCCCC		26.4821440633
306PhosphorylationPTEEESHSATPTPKP
CCCCCCCCCCCCCCC		43.0228889911
308PhosphorylationEEESHSATPTPKPLS
CCCCCCCCCCCCCCC		30.6128889911
312UbiquitinationHSATPTPKPLSYSEV
CCCCCCCCCCCHHHH		62.1524961812
315PhosphorylationTPTPKPLSYSEVVER
CCCCCCCCHHHHHHH		34.8330377154
317PhosphorylationTPKPLSYSEVVERSV
CCCCCCHHHHHHHHH		22.1230377154
329PhosphorylationRSVVNETSKKGTPLS
HHHHCCCCCCCCCHH		26.6228889911
333PhosphorylationNETSKKGTPLSKLDS
CCCCCCCCCHHHCCC		29.9027214570
340PhosphorylationTPLSKLDSPALELQS
CCHHHCCCCCHHHCC		23.6222369663
347PhosphorylationSPALELQSKPDKSDE
CCCHHHCCCCCCCCC		59.8020377248
348UbiquitinationPALELQSKPDKSDEF
CCHHHCCCCCCCCCC		44.2524961812
351UbiquitinationELQSKPDKSDEFKGG
HHCCCCCCCCCCCCC		69.2224961812
356UbiquitinationPDKSDEFKGGDEQGF
CCCCCCCCCCCHHCC		60.9924961812
376PhosphorylationDKAQLDVSNDKDKGS
CCCEECCCCCCCCCC		38.6925704821
383PhosphorylationSNDKDKGSETDVDKQ
CCCCCCCCCCCCHHH		42.9628889911
385PhosphorylationDKDKGSETDVDKQFT
CCCCCCCCCCHHHCE		42.9128889911
401PhosphorylationKNVEREHSMSRTKYN
CCHHHCCCCCCEECC		17.4417287358
405PhosphorylationREHSMSRTKYNGNHN
HCCCCCCEECCCCCC		30.4921440633
491PhosphorylationNNEEGLTSDSSLDAS
CCCCCCCCCCCCCCC		40.3028889911
494PhosphorylationEGLTSDSSLDASGNK
CCCCCCCCCCCCCCC		34.9528889911
516PhosphorylationTSNTQQYSIFKPASG
CCCCCEEEEECCCCC		19.7430377154
519UbiquitinationTQQYSIFKPASGFLG
CCEEEEECCCCCCCC		37.6924961812
522PhosphorylationYSIFKPASGFLGQGN
EEEECCCCCCCCCCC		38.3124909858
577PhosphorylationGSRGGRGSSGNYSNY
CCCCCCCCCCCCCCC		33.4428889911
584PhosphorylationSSGNYSNYNNRTTDM
CCCCCCCCCCCCCCC		14.1027017623
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PSP2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PSP2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PSP2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
IF4F2_YEASTTIF4632physical
16554755
IF4E_YEASTCDC33physical
16554755
DBP1_YEASTDBP1physical
18467557
DED1_YEASTDED1physical
22615397
VPS8_YEASTVPS8genetic
27708008
RAD16_YEASTRAD16genetic
27708008
CCZ1_YEASTCCZ1genetic
27708008
AIM4_YEASTAIM4genetic
27708008
HPC2_YEASTHPC2genetic
27708008
SLX5_YEASTSLX5genetic
27708008
CRD1_YEASTCRD1genetic
27708008
AAKG_YEASTSNF4genetic
27708008
SKN1_YEASTSKN1genetic
27708008
VPS51_YEASTVPS51genetic
27708008
FUMH_YEASTFUM1genetic
27708008
EAF3_YEASTEAF3genetic
27708008
BDH1_YEASTBDH1genetic
27708008
YAJ9_YEASTYAR029Wgenetic
27708008
H2A2_YEASTHTA2genetic
27708008
PIN4_YEASTPIN4genetic
27708008
TEC1_YEASTTEC1genetic
27708008
FTH1_YEASTFTH1genetic
27708008
DUR1_YEASTDUR1,2genetic
27708008
SGF29_YEASTSGF29genetic
27708008
PAT1_YEASTPAT1genetic
27708008
CSM1_YEASTCSM1genetic
27708008
GPR1_YEASTGPR1genetic
27708008
CYK3_YEASTCYK3genetic
27708008
DTD_YEASTDTD1genetic
27708008
PP4C_YEASTPPH3genetic
27708008
VPS41_YEASTVPS41genetic
27708008
SWI5_YEASTSWI5genetic
27708008
MET32_YEASTMET32genetic
27708008
BL1S4_YEASTCNL1genetic
27708008
RAD51_YEASTRAD51genetic
27708008
RAD4_YEASTRAD4genetic
27708008
GCN20_YEASTGCN20genetic
27708008
MIG1_YEASTMIG1genetic
27708008
HUR1_YEASTHUR1genetic
27708008
RL26B_YEASTRPL26Bgenetic
27708008
DRN1_YEASTDRN1genetic
27708008
YG2W_YEASTYGR111Wgenetic
27708008
SNF6_YEASTSNF6genetic
27708008
DOG1_YEASTDOG1genetic
27708008
SSP1_YEASTSSP1genetic
27708008
CTF8_YEASTCTF8genetic
27708008
PSMD9_YEASTNAS2genetic
27708008
HPM1_YEASTHPM1genetic
27708008
IMPX_YEASTIMP2genetic
27708008
CUL8_YEASTRTT101genetic
27708008
IF4A_YEASTTIF2genetic
27708008
RL14A_YEASTRPL14Agenetic
27708008
IXR1_YEASTIXR1genetic
27708008
AIM26_YEASTAIM26genetic
27708008
VPS24_YEASTVPS24genetic
27708008
KKQ8_YEASTKKQ8genetic
27708008
PET10_YEASTPET10genetic
27708008
CCW12_YEASTCCW12genetic
27708008
SRN2_YEASTSRN2genetic
27708008
ACE2_YEASTACE2genetic
27708008
MMR1_YEASTMMR1genetic
27708008
CDA2_YEASTCDA2genetic
27708008
MMS22_YEASTMMS22genetic
27708008
FKS1_YEASTFKS1genetic
27708008
TSR2_YEASTTSR2genetic
27708008
OAT_YEASTCAR2genetic
27708008
CTL1_YEASTCTL1genetic
27708008
LCF4_YEASTFAA4genetic
27708008
TMA23_YEASTTMA23genetic
27708008
GAS1_YEASTGAS1genetic
27708008
BRE5_YEASTBRE5genetic
27708008
LAG2_YEASTLAG2genetic
27708008
HST1_YEASTHST1genetic
27708008
RRP6_YEASTRRP6genetic
27708008
2A5D_YEASTRTS1genetic
27708008
CY1_YEASTCYT1genetic
27708008
DIA2_YEASTDIA2genetic
27708008
VPH1_YEASTVPH1genetic
27708008
UME1_YEASTUME1genetic
27708008
KES1_YEASTKES1genetic
27708008
AIM44_YEASTAIM44genetic
27708008
YME1_YEASTYME1genetic
27708008
SPEE_YEASTSPE3genetic
27708008
AXL1_YEASTAXL1genetic
27708008
KAR3_YEASTKAR3genetic
27708008
MMS1_YEASTMMS1genetic
27708008
HDA3_YEASTHDA3genetic
27708008
MLC2_YEASTMLC2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PSP2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-236; SER-238 ANDSER-340, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-238, AND MASSSPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-401, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-238 AND SER-340, ANDMASS SPECTROMETRY.

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