LCF4_YEAST - dbPTM
LCF4_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LCF4_YEAST
UniProt AC P47912
Protein Name Long-chain-fatty-acid--CoA ligase 4
Gene Name FAA4
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 694
Subcellular Localization
Protein Description Esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. Contributes, with FAA1, to the activation of imported myristate..
Protein Sequence MTEQYSVAVGEAANEHETAPRRNIRVKDQPLIRPINSSASTLYEFALECFTKGGKRDGMAWRDIIDIHETKKTIVKRVDGKDKPIEKTWLYYELTPYITMTYEEMICVMHDIGRGLIKIGVKPNGENKFHIFASTSHKWMKTFLGCMSQGIPVVTAYDTLGESGLIHSMVETDSVAIFTDNQLLSKLAVPLKTAKNVKFVIHNEPIDPSDKRQNGKLYKAAKDAVDKIKEVRPDIKIYSFDEIIEIGKKAKDEVELHFPKPEDPACIMYTSGSTGTPKGVVLTHYNIVAGIGGVGHNVIGWIGPTDRIIAFLPLAHIFELTFEFEAFYWNGILGYANVKTLTPTSTRNCQGDLMEFKPTVMVGVAAVWETVRKGILAKINELPGWSQTLFWTVYALKERNIPCSGLLSGLIFKRIREATGGNLRFILNGGSAISIDAQKFLSNLLCPMLIGYGLTEGVANACVLEPEHFDYGIAGDLVGTITAKLVDVEDLGYFAKNNQGELLFKGAPICSEYYKNPEETAAAFTDDGWFRTGDIAEWTPKGQVKIIDRKKNLVKTLNGEYIALEKLESIYRSNPYVQNICVYADENKVKPVGIVVPNLGHLSKLAIELGIMVPGEDVESYIHEKKLQDAVCKDMLSTAKSQGLNGIELLCGIVFFEEEWTPENGLVTSAQKLKRRDILAAVKPDVERVYKENT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
27UbiquitinationPRRNIRVKDQPLIRP
CCCCCCCCCCCCEEE		40.5717644757
52UbiquitinationFALECFTKGGKRDGM
HHHHHHHCCCCCCCC		45.4717644757
71UbiquitinationIIDIHETKKTIVKRV
EEEHHHCCCEEEEEC		44.9617644757
72UbiquitinationIDIHETKKTIVKRVD
EEHHHCCCEEEEECC		51.4017644757
83UbiquitinationKRVDGKDKPIEKTWL
EECCCCCCCCEEEEE		51.9223749301
192UbiquitinationSKLAVPLKTAKNVKF
HHHCCCCCCCCCEEE		40.1323749301
198UbiquitinationLKTAKNVKFVIHNEP
CCCCCCEEEEEECCC		43.2217644757
211AcetylationEPIDPSDKRQNGKLY
CCCCCCHHHHCCCHH		61.2924489116
211UbiquitinationEPIDPSDKRQNGKLY
CCCCCCHHHHCCCHH		61.2917644757
227UbiquitinationAAKDAVDKIKEVRPD
HHHHHHHHHHHHCCC		49.4217644757
229UbiquitinationKDAVDKIKEVRPDIK
HHHHHHHHHHCCCCE		56.7617644757
236UbiquitinationKEVRPDIKIYSFDEI
HHHCCCCEEEEHHHH		42.8617644757
248UbiquitinationDEIIEIGKKAKDEVE
HHHHHHHHHCCCEEE		56.0417644757
249UbiquitinationEIIEIGKKAKDEVEL
HHHHHHHHCCCEEEE		56.2917644757
251UbiquitinationIEIGKKAKDEVELHF
HHHHHHCCCEEEECC		64.4017644757
260UbiquitinationEVELHFPKPEDPACI
EEEECCCCCCCCCEE		61.1617644757
278UbiquitinationSGSTGTPKGVVLTHY
CCCCCCCCEEEEEEC		65.2617644757
378UbiquitinationVRKGILAKINELPGW
HHHCHHHHHHCCCCH		42.4917644757
397UbiquitinationFWTVYALKERNIPCS
HHHHHHHHHCCCCCC		46.5923749301
413AcetylationLLSGLIFKRIREATG
HHHHHHHHHHHHHCC		39.6624489116
413UbiquitinationLLSGLIFKRIREATG
HHHHHHHHHHHHHCC		39.6623749301
484UbiquitinationLVGTITAKLVDVEDL
HHHEEEEEEECHHHH		40.1517644757
496UbiquitinationEDLGYFAKNNQGELL
HHHCCEEECCCCCEE		46.6723749301
505UbiquitinationNQGELLFKGAPICSE
CCCCEEECCCCCCHH		54.8823749301
515UbiquitinationPICSEYYKNPEETAA
CCCHHHCCCHHHHHH		66.1923749301
541UbiquitinationDIAEWTPKGQVKIID
CCEECCCCCCEEEEE		55.3823749301
545UbiquitinationWTPKGQVKIIDRKKN
CCCCCCEEEEECCCC		26.5122817900
555UbiquitinationDRKKNLVKTLNGEYI
ECCCCHHHHHCCEEE		50.9217644757
566AcetylationGEYIALEKLESIYRS
CEEEEHHHHHHHHHC		59.4124489116
566UbiquitinationGEYIALEKLESIYRS
CEEEEHHHHHHHHHC		59.4117644757
588UbiquitinationCVYADENKVKPVGIV
EEEECCCCCCCEEEE		49.9817644757
590UbiquitinationYADENKVKPVGIVVP
EECCCCCCCEEEECC		35.2817644757
604UbiquitinationPNLGHLSKLAIELGI
CCCHHHHHHHHHHCC		48.5817644757
625UbiquitinationVESYIHEKKLQDAVC
HHHHHCHHHHHHHHH		44.6217644757
626UbiquitinationESYIHEKKLQDAVCK
HHHHCHHHHHHHHHH		48.6923749301
633UbiquitinationKLQDAVCKDMLSTAK
HHHHHHHHHHHHHHH		39.3023749301
640UbiquitinationKDMLSTAKSQGLNGI
HHHHHHHHHCCCCHH		43.3215699485
672UbiquitinationGLVTSAQKLKRRDIL
CCCCCHHHHCCCHHH		56.5515699485
674UbiquitinationVTSAQKLKRRDILAA
CCCHHHHCCCHHHHH		53.0417644757
683UbiquitinationRDILAAVKPDVERVY
CHHHHHHCCCHHHHH		30.6717644757
683AcetylationRDILAAVKPDVERVY
CHHHHHHCCCHHHHH		30.6724489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LCF4_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LCF4_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LCF4_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FIMB_YEASTSAC6physical
11805837
PSR2_YEASTPSR2physical
11805837
FAT1_YEASTFAT1physical
12601005
FAT1_YEASTFAT1genetic
12601005
ACON_YEASTACO1physical
16429126
CLU_YEASTCLU1physical
16429126
PGC1_YEASTPGC1physical
16429126
GCN1_YEASTGCN1physical
16429126
PYR1_YEASTURA2physical
16429126
SNC1_YEASTSNC1genetic
16233202
ACO1_YEASTOLE1genetic
20516150
DCOR_YEASTSPE1genetic
21623372
COX5A_YEASTCOX5Agenetic
21623372
SDHB_YEASTSDH2genetic
21623372
TGL2_YEASTTGL2genetic
21623372
ADH3_YEASTADH3genetic
21623372
OM14_YEASTOM14physical
21748599
PEX17_YEASTPEX17physical
21748599
PEX19_YEASTPEX19physical
21748599
LCF4_YEASTFAA4physical
22940862
SLG1_YEASTSLG1genetic
23891562
LCF1_YEASTFAA1genetic
23891562
ACOT5_MOUSEAcot5genetic
24769906
SEC7_YEASTSEC7genetic
27708008
CND2_YEASTBRN1genetic
27708008
TCPZ_YEASTCCT6genetic
27708008
RIFK_YEASTFMN1genetic
27708008
GPI11_YEASTGPI11genetic
27708008
STT3_YEASTSTT3genetic
27708008
PRP18_YEASTPRP18genetic
27708008
ARP4_YEASTARP4genetic
27708008
PRP21_YEASTPRP21genetic
27708008
SPC3_YEASTSPC3genetic
27708008
TAD3_YEASTTAD3genetic
27708008
DCP2_YEASTDCP2genetic
27708008
CAP_YEASTSRV2genetic
27708008
CH10_YEASTHSP10genetic
27708008
PMP1_YEASTPMP1physical
26404137
PRY1_YEASTPRY1genetic
28365570
PRY2_YEASTPRY2genetic
28365570
PRY3_YEASTPRY3genetic
28365570
DCAM_YEASTSPE2genetic
27453043
ERG26_YEASTERG26genetic
27453043
AAKG_YEASTSNF4genetic
27453043
HIR2_YEASTHIR2genetic
27453043
BRE1_YEASTBRE1genetic
27453043
SWI6_YEASTSWI6genetic
27453043
SCH9_YEASTSCH9genetic
27453043
CSK22_YEASTCKA2genetic
27453043
DCOR_YEASTSPE1genetic
27453043
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LCF4_YEAST

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Related Literatures of Post-Translational Modification

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