PGC1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PGC1_YEAST
• UniProt AC: Q08959
• Protein Name: Phosphatidylglycerol phospholipase C
• Gene Name: PGC1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 321
• Subcellular Localization: Mitochondrion membrane ; Single-pass type IV membrane protein .
• Protein Description: Phosphatidylglycerol phospholipase required for the removal of excess phosphatidylglycerol (PG) via a phospholipase C-type degradation mechanism..
• Protein Sequence: MVEIVGHRAFKARYPENTLLAFEKAYAAGADVIETDLQMTSDGMVVVNHDSDTGRMWDKNLVIGESTWEEVKRLRCKEDGSLAMMTLKEILTWAVCHPGAKLMLDIKFTNEKIIMIKTFVIMLEVKNDLKFWQERITWGLWLLDWYDFGIETGVLKDFKVIVISLSLDIASQFVKRSLTLNDPHYKLFGISVHFVSSWTSQFRLRLLPVLMKNDIKVYLWTVNKPIDFKYLCELPIHGAITDDPIKARKLCDGHTVAKKPTAEKKFVAPSLASVDGLRFHAFIKVYNILCTLLYSKWVHIKLCGWSIAYVIFLFLRTIHFL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Ubiquitination	IVGHRAFKARYPENT EECCCHHHHCCCHHH	30.85	17644757
24	Ubiquitination	NTLLAFEKAYAAGAD HHHHHHHHHHHCCCC	40.00	17644757
40	Phosphorylation	IETDLQMTSDGMVVV EEEECEECCCCEEEE	15.65	27017623
41	Phosphorylation	ETDLQMTSDGMVVVN EEECEECCCCEEEEE	27.16	27017623
51	Phosphorylation	MVVVNHDSDTGRMWD EEEEECCCCCCCCCC	29.53	27017623
53	Phosphorylation	VVNHDSDTGRMWDKN EEECCCCCCCCCCCC	30.55	27017623
59	Ubiquitination	DTGRMWDKNLVIGES CCCCCCCCCEEEECC	36.35	17644757
72	Ubiquitination	ESTWEEVKRLRCKED CCCHHHHHHHCCCCC	49.33	17644757
88	Ubiquitination	SLAMMTLKEILTWAV CEEEEEHHHHHHHHH	33.28	17644757
101	Ubiquitination	AVCHPGAKLMLDIKF HHHCCCCEEEEEEEE	40.10	17644757
216	Ubiquitination	VLMKNDIKVYLWTVN HHCCCCEEEEEEECC	27.91	17644757
224	Ubiquitination	VYLWTVNKPIDFKYL EEEEECCCCCCHHHE	38.73	17644757
229	Ubiquitination	VNKPIDFKYLCELPI CCCCCCHHHEECCCC	33.30	17644757
246	Ubiquitination	AITDDPIKARKLCDG CCCCCCHHHHHHCCC	47.75	17644757
249	Ubiquitination	DDPIKARKLCDGHTV CCCHHHHHHCCCCCC	59.32	17644757
258	Ubiquitination	CDGHTVAKKPTAEKK CCCCCCCCCCCCCCC	55.75	17644757
259	Ubiquitination	DGHTVAKKPTAEKKF CCCCCCCCCCCCCCC	37.55	17644757

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PGC1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PGC1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PGC1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DAP1_YEAST	DAP1	genetic	16269340
RBD2_YEAST	RBD2	genetic	16269340
RRP1_YEAST	RRP1	genetic	27708008
RL24B_YEAST	RPL24B	genetic	27708008
CUE4_YEAST	CUE4	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.