| UniProt ID | PSR2_YEAST | |
|---|---|---|
| UniProt AC | Q07949 | |
| Protein Name | Probable phosphatase PSR2 | |
| Gene Name | PSR2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 397 | |
| Subcellular Localization | Cell membrane. | |
| Protein Description | Probable phosphatase. Involved in the response to sodium and lithium ion stress (but not to potassium or sorbitol stress) by inducing transcription of the sodium pump ENA1/PMR2. Acts through a calcineurin-independent pathway and is functionally redundant with PSR1. Also involved in the general stress response; acts together with WHI2 to activate stress response element (STRE)-mediated gene expression, possibly through dephosphorylation of MSN2.. | |
| Protein Sequence | MGFIANILCCSSDTSKTHRQRQPPETNHNRNRNRKHSSNKAQTQGRKQKATPNGDKMQYSTPEILLSSSDSGSNAGSKTMQENGNSGNGKLAPLSRDHSNNSYDEEKEYEDYNEGDVEMTEVNNAGEEEEEDDEAKEKQDHVVHEYNVDADRNSSINDEAPPQQGLYQVGQEDMNPQYVASSPDNDLNLIPTTEEDFSDLTHLQPDQYHAPGYDTLLPPKLQEFQQKKCLILDLDETLVHSSFKYMHSADFVLPVEIDDQVHNVYVIKRPGVDEFLNRVSQLYEVVVFTASVSRYANPLLDTLDPNGTIHHRLFREACYNYEGNYIKNLSQIGRPLSETIILDNSPASYIFHPQHAVPISSWFSDTHDNELLDIIPLLEDLSSGNVLDVGSVLDVTI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 9 | S-palmitoylation | GFIANILCCSSDTSK CCEEEEEEECCCCCH | 1.55 | 10777497 | |
| 10 | S-palmitoylation | FIANILCCSSDTSKT CEEEEEEECCCCCHH | 3.80 | 10777497 | |
| 56 | Ubiquitination | KATPNGDKMQYSTPE CCCCCCCCCCCCCCE | 29.33 | 23749301 | |
| 59 | Phosphorylation | PNGDKMQYSTPEILL CCCCCCCCCCCEEEE | 15.83 | 19779198 | |
| 67 | Phosphorylation | STPEILLSSSDSGSN CCCEEEECCCCCCCC | 25.09 | 23749301 | |
| 68 | Phosphorylation | TPEILLSSSDSGSNA CCEEEECCCCCCCCC | 37.83 | 23749301 | |
| 69 | Phosphorylation | PEILLSSSDSGSNAG CEEEECCCCCCCCCC | 32.21 | 21551504 | |
| 71 | Phosphorylation | ILLSSSDSGSNAGSK EEECCCCCCCCCCCC | 46.17 | 21440633 | |
| 73 | Phosphorylation | LSSSDSGSNAGSKTM ECCCCCCCCCCCCCC | 27.71 | 20377248 | |
| 77 | Phosphorylation | DSGSNAGSKTMQENG CCCCCCCCCCCHHCC | 23.65 | 20377248 | |
| 79 | Phosphorylation | GSNAGSKTMQENGNS CCCCCCCCCHHCCCC | 26.28 | 23749301 | |
| 90 | Ubiquitination | NGNSGNGKLAPLSRD CCCCCCCCCCCCCCC | 45.54 | 23749301 | |
| 95 | Phosphorylation | NGKLAPLSRDHSNNS CCCCCCCCCCCCCCC | 34.30 | 19823750 | |
| 99 | Phosphorylation | APLSRDHSNNSYDEE CCCCCCCCCCCCCHH | 41.83 | 20377248 | |
| 102 | Phosphorylation | SRDHSNNSYDEEKEY CCCCCCCCCCHHHHH | 37.91 | 21440633 | |
| 103 | Phosphorylation | RDHSNNSYDEEKEYE CCCCCCCCCHHHHHC | 29.51 | 20377248 | |
| 138 | Ubiquitination | EDDEAKEKQDHVVHE CCHHHHHHHCCEEEE | 61.39 | 24961812 | |
| 228 | Ubiquitination | LQEFQQKKCLILDLD HHHHHHCCCEEEECC | 29.90 | 17644757 | |
| 244 | Ubiquitination | TLVHSSFKYMHSADF HHHHHHHCCCCCCCE | 43.54 | 17644757 | |
| 293 | Phosphorylation | VVFTASVSRYANPLL HEEEECHHHHCCHHH | 19.65 | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PSR2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PSR2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PSR2_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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