HXT6_YEAST - dbPTM
HXT6_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HXT6_YEAST
UniProt AC P39003
Protein Name High-affinity hexose transporter HXT6
Gene Name HXT6
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 570
Subcellular Localization Membrane
Multi-pass membrane protein.
Protein Description High-affinity glucose transporter..
Protein Sequence MSQDAAIAEQTPVEHLSAVDSASHSVLSTPSNKAERDEIKAYGEGEEHEPVVEIPKRPASAYVTVSIMCIMIAFGGFVFGWDTGTISGFINQTDFIRRFGMKHKDGTNYLSKVRTGLIVSIFNIGCAIGGIILSKLGDMYGRKVGLIVVVVIYIIGIIIQIASINKWYQYFIGRIISGLGVGGIAVLSPMLISEVSPKHLRGTLVSCYQLMITAGIFLGYCTNFGTKNYSNSVQWRVPLGLCFAWALFMIGGMTFVPESPRYLAEVGKIEEAKRSIAVSNKVAVDDPSVLAEVEAVLAGVEAEKLAGNASWGELFSSKTKVLQRLIMGAMIQSLQQLTGDNYFFYYGTTIFKAVGLSDSFETSIVLGIVNFASTFVGIYVVERYGRRTCLLWGAASMTACMVVYASVGVTRLWPNGQDQPSSKGAGNCMIVFACFYIFCFATTWAPIPYVVVSETFPLRVKSKAMSIATAANWLWGFLIGFFTPFITGAINFYYGYVFMGCLVFMFFYVLLVVPETKGLTLEEVNTMWEEGVLPWKSASWVPPSRRGANYDAEEMAHDDKPLYKRMFSTK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSQDAAIAE
------CCHHHHHHH		36.4522369663
11PhosphorylationDAAIAEQTPVEHLSA
HHHHHHCCCHHHHHH		22.3222369663
17PhosphorylationQTPVEHLSAVDSASH
CCCHHHHHHHCCCCC		28.3122369663
21PhosphorylationEHLSAVDSASHSVLS
HHHHHHCCCCCCCCC		25.6822369663
23PhosphorylationLSAVDSASHSVLSTP
HHHHCCCCCCCCCCC		21.9022369663
25PhosphorylationAVDSASHSVLSTPSN
HHCCCCCCCCCCCCC		23.4322369663
28PhosphorylationSASHSVLSTPSNKAE
CCCCCCCCCCCCHHH		35.8022369663
29PhosphorylationASHSVLSTPSNKAER
CCCCCCCCCCCHHHH		26.9522369663
31PhosphorylationHSVLSTPSNKAERDE
CCCCCCCCCHHHHHH		51.5622369663
33UbiquitinationVLSTPSNKAERDEIK
CCCCCCCHHHHHHHH		56.8324961812
40UbiquitinationKAERDEIKAYGEGEE
HHHHHHHHHCCCCCC		33.2423749301
91N-linked_GlycosylationGTISGFINQTDFIRR
CCHHHHCCHHHHHHH		36.12-
177PhosphorylationYFIGRIISGLGVGGI
HHHHHHHCCCCCCHH		26.1223749301
193PhosphorylationVLSPMLISEVSPKHL
HHCCHHHCCCCHHHH		28.1623749301
198UbiquitinationLISEVSPKHLRGTLV
HHCCCCHHHHHHHHH		48.0023749301
228N-linked_GlycosylationCTNFGTKNYSNSVQW
HCCCCCCCCCCCCCC		45.35-
229PhosphorylationTNFGTKNYSNSVQWR
CCCCCCCCCCCCCCC		15.7028889911
268UbiquitinationRYLAEVGKIEEAKRS
HHHHHHCCHHHHHHH		52.7123749301
2682-HydroxyisobutyrylationRYLAEVGKIEEAKRS
HHHHHHCCHHHHHHH		52.71-
2732-HydroxyisobutyrylationVGKIEEAKRSIAVSN
HCCHHHHHHHHEECC		50.38-
288PhosphorylationKVAVDDPSVLAEVEA
CEECCCHHHHHHHHH		36.4421440633
318UbiquitinationWGELFSSKTKVLQRL
HHHHHCCHHHHHHHH		51.6812872131
3202-HydroxyisobutyrylationELFSSKTKVLQRLIM
HHHCCHHHHHHHHHH		44.69-
544PhosphorylationSASWVPPSRRGANYD
CCCCCCCCCCCCCCC		28.6519779198
560UbiquitinationEEMAHDDKPLYKRMF
HHHCCCCCCHHHHHH		42.8712872131
564AcetylationHDDKPLYKRMFSTK-
CCCCCHHHHHHCCC-		45.1024489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseRSP5P39940
PMID:22199232
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HXT6_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HXT6_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HXT7_YEASTHXT7genetic
9151960
IAH1_YEASTIAH1genetic
21623372
SERB_YEASTSER2genetic
21623372
ARGJ_YEASTARG7genetic
21623372
KCS1_YEASTKCS1genetic
21623372
NRK1_YEASTNRK1genetic
21623372
ELO3_YEASTELO3genetic
21623372
MED8_YEASTMED8genetic
27708008
APC11_YEASTAPC11genetic
27708008
RPB1_YEASTRPO21genetic
27708008
ACT_YEASTACT1genetic
27708008
TAF6_YEASTTAF6genetic
27708008
SN114_YEASTSNU114genetic
27708008
PRP19_YEASTPRP19genetic
27708008
NEP1_YEASTEMG1genetic
27708008
XRN2_YEASTRAT1genetic
27708008
PROF_YEASTPFY1genetic
27708008
RPB2_YEASTRPB2genetic
27708008
SWC3_YEASTSWC3genetic
27708008
DEP1_YEASTDEP1genetic
27708008
SHE1_YEASTSHE1genetic
27708008
ECM8_YEASTECM8genetic
27708008
RXT2_YEASTRXT2genetic
27708008
SIF2_YEASTSIF2genetic
27708008
ADH5_YEASTADH5genetic
27708008
SWC5_YEASTSWC5genetic
27708008
RMD9L_YEASTYBR238Cgenetic
27708008
FUS1_YEASTFUS1genetic
27708008
MGR1_YEASTMGR1genetic
27708008
THRC_YEASTTHR4genetic
27708008
MTU1_YEASTSLM3genetic
27708008
BRE1_YEASTBRE1genetic
27708008
RLA1_YEASTRPP1Agenetic
27708008
YD157_YEASTYDL157Cgenetic
27708008
FMP45_YEASTFMP45genetic
27708008
RM01_YEASTMRPL1genetic
27708008
INO2_YEASTINO2genetic
27708008
AIM11_YEASTAIM11genetic
27708008
PT122_YEASTPET122genetic
27708008
YGY5_YEASTYGL235Wgenetic
27708008
RTF1_YEASTRTF1genetic
27708008
CHO2_YEASTCHO2genetic
27708008
CBP4_YEASTCBP4genetic
27708008
PHB2_YEASTPHB2genetic
27708008
SNF6_YEASTSNF6genetic
27708008
SDS3_YEASTSDS3genetic
27708008
ICE2_YEASTICE2genetic
27708008
FLX1_YEASTFLX1genetic
27708008
RM49_YEASTMRP49genetic
27708008
FMP46_YEASTFMP46genetic
27708008
PAM17_YEASTPAM17genetic
27708008
ERG3_YEASTERG3genetic
27708008
HOG1_YEASTHOG1genetic
27708008
UPS2_YEASTUPS2genetic
27708008
UPS1_YEASTUPS1genetic
27708008
RSA3_YEASTRSA3genetic
27708008
YL278_YEASTYLR278Cgenetic
27708008
ATP10_YEASTATP10genetic
27708008
SAM37_YEASTSAM37genetic
27708008
MGR3_YEASTMGR3genetic
27708008
MLH1_YEASTMLH1genetic
27708008
SWS2_YEASTSWS2genetic
27708008
MSN1_YEASTMSN1genetic
27708008
CY1_YEASTCYT1genetic
27708008
COQ7_YEASTCAT5genetic
27708008
MSC6_YEASTMSC6genetic
27708008
MGR2_YEASTMGR2genetic
27708008
YME1_YEASTYME1genetic
27708008
MSS18_YEASTMSS18genetic
27708008
KAR3_YEASTKAR3genetic
27708008
QCR2_YEASTQCR2genetic
27708008
CSR2_YEASTCSR2physical
28468835
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HXT6_YEAST

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Related Literatures of Post-Translational Modification
Ubiquitylation
ReferencePubMed
"A proteomics approach to understanding protein ubiquitination.";
Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D.,Marsischky G., Roelofs J., Finley D., Gygi S.P.;
Nat. Biotechnol. 21:921-926(2003).
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-560, AND MASSSPECTROMETRY.

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