FUS1_YEAST - dbPTM
FUS1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FUS1_YEAST
UniProt AC P11710
Protein Name Nuclear fusion protein FUS1
Gene Name FUS1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 512
Subcellular Localization Membrane
Single-pass membrane protein .
Protein Description Required for cell fusion. Negatively regulates Sho1p signaling to ensure efficient cell fusion.; Interacts with SHO1..
Protein Sequence MVATIMQTTTTVLTTVAAMSTTLASNYISSQASSSTSVTTVTTIATSIRSTPSNLLFSNVAAQPKSSSASTIGLSIGLPIGIFCFGLLILLCYFYLKRNSVSISNPPMSATIPREEEYCRRTNWFSRLFWQSKCEDQNSYSNRDIEKYNDTQWTSGDNMSSKIQYKISKPIIPQHILTPKKTVKNPYAWSGKNISLDPKVNEMEEEKVVDAFLYTKPPNIVHIESSMPSYNDLPSQKTVSSKKTALKTSEKWSYESPLSRWFLRGSTYFKDYGLSKTSLKTPTGAPQLKQMKMLSRISKGYFNESDIMPDERSPILEYNNTPLDANDSVNNLGNTTPDSQITSYRNNNIDLITARPHSVIYGTTAQQTLETNFNDHHDCNKSTEKHELIIPTPSKPLKKRKKRRQSKMYQHLQHLSRSKPLPLTPNSKYNGEASVQLGKTYTVIQDYEPRLTDEIRISLGEKVKILATHTDGWCLVEKCNTQKGSIHVSVDDKRYLNEDRGIVPGDCLQEYD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
102PhosphorylationYLKRNSVSISNPPMS
HHHHCCCCCCCCCCC		21.8128132839
139PhosphorylationSKCEDQNSYSNRDIE
HHCCCCCCCCCCCHH		25.0621551504
147UbiquitinationYSNRDIEKYNDTQWT
CCCCCHHHHCCCCCC		50.0823749301
160PhosphorylationWTSGDNMSSKIQYKI
CCCCCCCCCCEEEEE		34.4317330950
161PhosphorylationTSGDNMSSKIQYKIS
CCCCCCCCCEEEEEC		24.0228889911
162UbiquitinationSGDNMSSKIQYKISK
CCCCCCCCEEEEECC		26.9024961812
178PhosphorylationIIPQHILTPKKTVKN
CCCCCCCCCCCCCCC		32.2417330950
190PhosphorylationVKNPYAWSGKNISLD
CCCCCCCCCCCCCCC		31.5517330950
256PhosphorylationSEKWSYESPLSRWFL
CCCCCCCCCCHHHHH		23.9417330950
275PhosphorylationYFKDYGLSKTSLKTP
CCCCCCCCCCCCCCC		29.5317330950
277PhosphorylationKDYGLSKTSLKTPTG
CCCCCCCCCCCCCCC		35.6017330950
281PhosphorylationLSKTSLKTPTGAPQL
CCCCCCCCCCCCHHH		31.2317330950
301PhosphorylationLSRISKGYFNESDIM
HHHHHCCCCCHHHCC		13.6317330950
358PhosphorylationLITARPHSVIYGTTA
EEEECCCCEEEECCC		16.9417330950
424PhosphorylationRSKPLPLTPNSKYNG
CCCCCCCCCCCCCCC		20.6317330950
427PhosphorylationPLPLTPNSKYNGEAS
CCCCCCCCCCCCEEE		37.4128132839
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FUS1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FUS1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FUS1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SHO1_YEASTSHO1physical
15020407
SPA2_YEASTSPA2physical
15020407
PEA2_YEASTPEA2physical
11743162
SHO1_YEASTSHO1physical
11743162
BNI1_YEASTBNI1physical
11743162
BNR1_YEASTBNR1physical
11743162
PSK1_YEASTPSK1physical
11743162
KPC1_YEASTPKC1physical
11743162
ROM1_YEASTROM1physical
11743162
BUD2_YEASTBUD2physical
11743162
FIR1_YEASTFIR1physical
11743162
GIP4_YEASTGIP4physical
11743162
SEG2_YEASTSEG2physical
11743162
VAC7_YEASTVAC7physical
11743162
SIR1_YEASTSIR1physical
11743162
HAA1_YEASTHAA1physical
11743162
YNF8_YEASTYNL058Cphysical
11743162
PT127_YEASTPET127physical
11743162
IMP4_YEASTIMP4physical
11743162
CLF1_YEASTCLF1physical
11743162
YK03_YEASTYKR023Wphysical
11743162
FUS2_YEASTFUS2genetic
9614182
RV161_YEASTRVS161genetic
9614182
SPA2_YEASTSPA2genetic
9614182
FUS2_YEASTFUS2genetic
3302672
BNR1_YEASTBNR1physical
18280496
STE5_YEASTSTE5physical
18280496
BNR1_YEASTBNR1physical
19841731
EAF3_YEASTEAF3physical
19841731
GIP4_YEASTGIP4physical
19841731
HAA1_YEASTHAA1physical
19841731
PEA2_YEASTPEA2physical
19841731
SHO1_YEASTSHO1physical
19841731
SIP5_YEASTSIP5physical
19841731
SIR1_YEASTSIR1physical
19841731
SEG2_YEASTSEG2physical
19841731
EI2BB_YEASTGCD7physical
19841731
MET31_YEASTMET31physical
19841731
PIK1_YEASTPIK1physical
19841731
YRB1_YEASTYRB1genetic
11238397
BEM1_YEASTBEM1genetic
15514049
MID1_YEASTMID1physical
16093310
FUS2_YEASTFUS2genetic
20460435
SEC1_YEASTSEC1genetic
20460435
PRM1_YEASTPRM1genetic
20460435
HSP72_YEASTSSA2physical
22940862
EF1A_YEASTTEF2physical
22940862
HSP71_YEASTSSA1physical
22940862
GPR1_YEASTGPR1genetic
27708008
RAD4_YEASTRAD4genetic
27708008
ASK10_YEASTASK10genetic
27708008
IME2_YEASTIME2genetic
27708008
PER33_YEASTPER33genetic
27708008
TMN1_YEASTEMP70genetic
27708008
VTA1_YEASTVTA1genetic
27708008
YL194_YEASTYLR194Cgenetic
27708008
ARV1_YEASTARV1genetic
27708008
INO4_YEASTINO4genetic
27708008
PCL8_YEASTPCL8genetic
27708008
MMT2_YEASTMMT2genetic
27708008
FUS2_YEASTFUS2genetic
26865368
KEL1_YEASTKEL1genetic
26865368
MPS1_YEASTMPS1genetic
26865368
KEL2_YEASTKEL2genetic
26865368
FUS2_YEASTFUS2genetic
29066609
INO2_YEASTINO2genetic
29674565
PT122_YEASTPET122genetic
29674565
VAM7_YEASTVAM7genetic
29674565
APQ12_YEASTAPQ12genetic
29674565
CFT2_YEASTCFT2genetic
29674565
JNM1_YEASTJNM1genetic
29674565
CAP_YEASTSRV2genetic
29674565
MED10_YEASTNUT2genetic
29674565
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FUS1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-178; SER-190; SER-256;THR-281 AND THR-424, AND MASS SPECTROMETRY.

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