| UniProt ID | PRM1_YEAST | |
|---|---|---|
| UniProt AC | P53835 | |
| Protein Name | Plasma membrane fusion protein PRM1 | |
| Gene Name | PRM1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 661 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein . Localizes at sites of cell fusion during mating. |
|
| Protein Description | Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.. | |
| Protein Sequence | MSGFKCYLQLGDRLSQIWLNKYTLVLLLAMLKLLFFSKSIQHAIEVSETYILSNCYSIDSLYSKMTDNTPHYLGIMGNYLIEKGMEETVKATLETLSLIVYASEGLVNFAIDLYLGTYACLIVSAVDGTVDVATNITEKLISLVNDTVSSVANELDTGLNDISKIINKVIKAASKVENFFTGDDDDSNMTSSIKSVNLTISALHNLYIPSSINDKLEELSAKTPDFAQVKNTTKNLISVPFNEVRKNIKAVNASNIIGDTSVLYVPPVSLDNSTGICSSNQSEILAFYSILGHVLKIATVVCITVLICFAVGAMAPVAWNEIKLWRRLCGMRDHYMLSRQDSYTSFSSENTHELKDPFRDPPIQNGQYDVIASYQQCFQTWNTRIAGWMTNLVTFGKSPENIDPKTKQKIEWVVAYMTSERALCVLGIGLLGILVCICQFVMIALLKHKISHSLTSNDGDGVQNLLKSSTAVDIENQMSLWSVQTNKYINTTETNINQEVFGWINTTTLSVNNTVATMISDIDTTLADVFNGTLLYNPMKTVVGCAIENKLYTIEKAMTWIHDKAQLHIPRINGTQIKQALAKQTDNSTIPTASSTSAATENLLENLVNDMREGLLKILRAYHRITLGELTVALVILAVWLVQLPIALVILRLRLRKATFD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSGFKCYLQ ------CCCCEEEEE | 53.59 | 26447709 | |
| 7 | Phosphorylation | -MSGFKCYLQLGDRL -CCCCEEEEECCHHH | 9.70 | 26447709 | |
| 15 | Phosphorylation | LQLGDRLSQIWLNKY EECCHHHHHHHHCHH | 22.10 | 26447709 | |
| 66 | Phosphorylation | DSLYSKMTDNTPHYL HHHHHHCCCCCCCCC | 29.81 | 27017623 | |
| 79 | Phosphorylation | YLGIMGNYLIEKGME CCCHHHHHHHHHCCH | 11.88 | 27017623 | |
| 88 | Phosphorylation | IEKGMEETVKATLET HHHCCHHHHHHHHHH | 17.63 | 27017623 | |
| 135 | N-linked_Glycosylation | GTVDVATNITEKLIS CCCCHHHHHHHHHHH | 29.46 | - | |
| 145 | N-linked_Glycosylation | EKLISLVNDTVSSVA HHHHHHHHHHHHHHH | 44.52 | - | |
| 188 | N-linked_Glycosylation | TGDDDDSNMTSSIKS CCCCCCCCCCHHCHH | 44.75 | - | |
| 197 | N-linked_Glycosylation | TSSIKSVNLTISALH CHHCHHHEEEHHHHH | 38.26 | - | |
| 231 | N-linked_Glycosylation | PDFAQVKNTTKNLIS CCHHHHCCCCCCEEE | 54.87 | - | |
| 252 | N-linked_Glycosylation | RKNIKAVNASNIIGD HHHCCCCCHHHHCCC | 42.38 | - | |
| 272 | N-linked_Glycosylation | VPPVSLDNSTGICSS ECCCCCCCCCCCCCC | 46.92 | - | |
| 280 | N-linked_Glycosylation | STGICSSNQSEILAF CCCCCCCCHHHHHHH | 32.86 | - | |
| 338 | Phosphorylation | MRDHYMLSRQDSYTS CCCCHHCCCCCCCCC | 16.03 | 27017623 | |
| 348 | Phosphorylation | DSYTSFSSENTHELK CCCCCCCCCCCCCCC | 32.62 | 27017623 | |
| 351 | Phosphorylation | TSFSSENTHELKDPF CCCCCCCCCCCCCCC | 16.81 | 27017623 | |
| 490 | N-linked_Glycosylation | VQTNKYINTTETNIN HCCCCEECCCCCCCC | 37.55 | - | |
| 505 | N-linked_Glycosylation | QEVFGWINTTTLSVN HHHHEEEECCEEEEC | 25.51 | - | |
| 512 | N-linked_Glycosylation | NTTTLSVNNTVATMI ECCEEEECCHHHHHH | 34.77 | - | |
| 531 | N-linked_Glycosylation | TTLADVFNGTLLYNP CHHHHHCCCEECCCC | 42.25 | - | |
| 573 | N-linked_Glycosylation | QLHIPRINGTQIKQA HHCCCCCCHHHHHHH | 49.06 | - | |
| 587 | N-linked_Glycosylation | ALAKQTDNSTIPTAS HHHHCCCCCCCCCCC | 44.43 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PRM1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PRM1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PRM1_YEAST !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ERG6_YEAST | ERG6 | genetic | 18299351 | |
| ERG2_YEAST | ERG2 | genetic | 18299351 | |
| ERG3_YEAST | ERG3 | genetic | 18299351 | |
| PRM1_YEAST | PRM1 | physical | 19933274 | |
| ERG4_YEAST | ERG4 | genetic | 20150508 | |
| MKAR_YEAST | IFA38 | physical | 16093310 | |
| OST4_YEAST | OST4 | physical | 16093310 | |
| ERG6_YEAST | ERG6 | genetic | 20460435 | |
| PRM1_YEAST | PRM1 | physical | 20485669 | |
| SEC22_YEAST | SEC22 | physical | 20729291 | |
| ERG6_YEAST | ERG6 | genetic | 20729291 | |
| AYR1_YEAST | AYR1 | genetic | 23891562 | |
| TAF12_YEAST | TAF12 | genetic | 27708008 | |
| COG3_YEAST | COG3 | genetic | 27708008 | |
| GPI10_YEAST | GPI10 | genetic | 27708008 | |
| YIP1_YEAST | YIP1 | genetic | 27708008 | |
| SC61A_YEAST | SEC61 | genetic | 27708008 | |
| ORC1_YEAST | ORC1 | genetic | 27708008 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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