FIR1_YEAST - dbPTM
FIR1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FIR1_YEAST
UniProt AC P40020
Protein Name Factor interacting with REF2
Gene Name FIR1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 876
Subcellular Localization Bud neck .
Protein Description Involved in 3' mRNA processing. Positively regulates poly(A) synthesis..
Protein Sequence MSLPVTPVKSKVCSTLSIQHEMDHDQCRDVLCPRENLLAINRTNNIESVAIPRQRSSKNKKPHEHTQSQVRFSIPDPNEISQDSPLKIVFPKSGNETERRMSTSSLLMNSHGHLVDMHSKILVDVPKEVWKFHHNRRKKCESRHRKTRSDVRSNTSSSGKEPNHSRSKSLQSIIVDTMNTYRATEVETSINENTSNISQVSPLNLSFDRPPPLTPEKNLYLTPESPLNRYHLPVPLEISLPPYLSPQNKDKKRSSLVYDGDGYSQFQEGNTSSSTESSLEQPSSSYSDEDDSIPYAHHDVSFELNNADADKLLGIDENANVNLKIQRRNLKNPQHIKSKTDRECEEKNTEKNVSLKILSTPNKLIDIPDLEHMKSPPSTGLNGTLKFFQQFEPSEEPTSPTRQVNPESLDKLDMSFKFPSSTTNNNVDKVHENRNSGDTNNEDFLKVDTSPVNQSFESRRQMLIDLQKSPTNNNPRIHKHRRSRSVHNIDDISLNFEATSTPPAPTSAPSIPVEHSNPCTSIEIPKRSPLRFTSSPKTSDIPPEAQSPKNGSFLQEISVPSIQIIPDESISHTREPSPSLIECPEDENEAFSTEVADHSIAIISETKSVPSIEPFKPLSSFNSFGQEIQNKEPTPLNQTPTDLIGKQRNCVNPHSIPFSVLSSNSQSSQSGSSKSSYNSEFSSNTAITDTTSQPSVTINRSTLEHNFIEEKRSIKNLGHGPPSQKNNYSFPRNKNTPSNRHDLDFNTIYEKRDGKMVEVILLDEDEDVGLKNNDISRTRVCHAQKAKNEQQKKRLSHCNEILGMCDKTADDAKRIIYQLVNEKHKFSEKGQQTKPKKSRVLPPLPFPLYDEKGNSLIPNKYQSSIHNDIPSHRKLK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSLPVTPVK
------CCCCCCCCC		41.1828152593
6Phosphorylation--MSLPVTPVKSKVC
--CCCCCCCCCCCCC		22.0328152593
66PhosphorylationNKKPHEHTQSQVRFS
CCCCCCCCCCEEEEE		27.2523749301
73PhosphorylationTQSQVRFSIPDPNEI
CCCEEEEECCCHHHC		23.7328132839
81PhosphorylationIPDPNEISQDSPLKI
CCCHHHCCCCCCEEE		23.0424909858
84PhosphorylationPNEISQDSPLKIVFP
HHHCCCCCCEEEEEC		25.2122369663
102PhosphorylationNETERRMSTSSLLMN
CHHHHCHHHHHHHHC		24.2723749301
103PhosphorylationETERRMSTSSLLMNS
HHHHCHHHHHHHHCC		17.0027017623
104PhosphorylationTERRMSTSSLLMNSH
HHHCHHHHHHHHCCC		16.2223749301
105PhosphorylationERRMSTSSLLMNSHG
HHCHHHHHHHHCCCC		26.1323749301
110PhosphorylationTSSLLMNSHGHLVDM
HHHHHHCCCCCCCCC		19.5127017623
119PhosphorylationGHLVDMHSKILVDVP
CCCCCCCCCEEEECC		18.1127017623
120UbiquitinationHLVDMHSKILVDVPK
CCCCCCCCEEEECCH		25.9417644757
127UbiquitinationKILVDVPKEVWKFHH
CEEEECCHHHHHHHH		65.8217644757
131UbiquitinationDVPKEVWKFHHNRRK
ECCHHHHHHHHHHHH		39.7417644757
167PhosphorylationKEPNHSRSKSLQSII
CCCCCCCCHHHHHHH		29.6123749301
169PhosphorylationPNHSRSKSLQSIIVD
CCCCCCHHHHHHHHC		32.6523749301
172PhosphorylationSRSKSLQSIIVDTMN
CCCHHHHHHHHCCHH		21.4123749301
217UbiquitinationPPPLTPEKNLYLTPE
CCCCCCCCCEEECCC		54.1517644757
222PhosphorylationPEKNLYLTPESPLNR
CCCCEEECCCCCCCC		16.0828889911
225PhosphorylationNLYLTPESPLNRYHL
CEEECCCCCCCCCCC		35.5724930733
243PhosphorylationLEISLPPYLSPQNKD
EEEECCCCCCCCCCC		20.1922369663
245PhosphorylationISLPPYLSPQNKDKK
EECCCCCCCCCCCCC		20.7022369663
274PhosphorylationQEGNTSSSTESSLEQ
CCCCCCCCCCCCCCC		35.6419779198
349PhosphorylationRECEEKNTEKNVSLK
HHHHHHHCCCCEEEE		60.4421440633
359PhosphorylationNVSLKILSTPNKLID
CEEEEEECCCCCEEC		45.3421440633
360PhosphorylationVSLKILSTPNKLIDI
EEEEEECCCCCEECC		27.6921440633
375PhosphorylationPDLEHMKSPPSTGLN
CCHHHCCCCCCCCCC		34.1721440633
378PhosphorylationEHMKSPPSTGLNGTL
HHCCCCCCCCCCCCH		38.1921440633
379PhosphorylationHMKSPPSTGLNGTLK
HCCCCCCCCCCCCHH		52.0021440633
384PhosphorylationPSTGLNGTLKFFQQF
CCCCCCCCHHHHHCC		26.2121551504
386UbiquitinationTGLNGTLKFFQQFEP
CCCCCCHHHHHCCCC		43.9317644757
394PhosphorylationFFQQFEPSEEPTSPT
HHHCCCCCCCCCCCC		47.6022890988
398PhosphorylationFEPSEEPTSPTRQVN
CCCCCCCCCCCCCCC		51.0922890988
399PhosphorylationEPSEEPTSPTRQVNP
CCCCCCCCCCCCCCH		34.6825521595
401PhosphorylationSEEPTSPTRQVNPES
CCCCCCCCCCCCHHH		33.2422890988
408PhosphorylationTRQVNPESLDKLDMS
CCCCCHHHHHCCCEE		43.0322369663
417UbiquitinationDKLDMSFKFPSSTTN
HCCCEEEECCCCCCC		49.4017644757
429UbiquitinationTTNNNVDKVHENRNS
CCCCCCHHHHHCCCC		41.0017644757
436PhosphorylationKVHENRNSGDTNNED
HHHHCCCCCCCCCCC		34.5021440633
449PhosphorylationEDFLKVDTSPVNQSF
CCCEECCCCCCCCCH		37.6121440633
450PhosphorylationDFLKVDTSPVNQSFE
CCEECCCCCCCCCHH		23.5323749301
455PhosphorylationDTSPVNQSFESRRQM
CCCCCCCCHHHHHHH		26.2728889911
458PhosphorylationPVNQSFESRRQMLID
CCCCCHHHHHHHHHH		30.6529688323
469PhosphorylationMLIDLQKSPTNNNPR
HHHHHHCCCCCCCCH		24.8125704821
471PhosphorylationIDLQKSPTNNNPRIH
HHHHCCCCCCCCHHH		58.6427717283
485PhosphorylationHKHRRSRSVHNIDDI
HHHHCCCCCCCCCCE		29.0423749301
528PhosphorylationSIEIPKRSPLRFTSS
EEECCCCCCCCCCCC		34.1221440633
533PhosphorylationKRSPLRFTSSPKTSD
CCCCCCCCCCCCCCC		23.1222890988
534PhosphorylationRSPLRFTSSPKTSDI
CCCCCCCCCCCCCCC		41.7622890988
535PhosphorylationSPLRFTSSPKTSDIP
CCCCCCCCCCCCCCC		27.6222890988
537UbiquitinationLRFTSSPKTSDIPPE
CCCCCCCCCCCCCCC		63.7115699485
538PhosphorylationRFTSSPKTSDIPPEA
CCCCCCCCCCCCCCC		34.7122890988
539PhosphorylationFTSSPKTSDIPPEAQ
CCCCCCCCCCCCCCC		39.4021440633
547PhosphorylationDIPPEAQSPKNGSFL
CCCCCCCCCCCCCCC		44.9122890988
549UbiquitinationPPEAQSPKNGSFLQE
CCCCCCCCCCCCCEE		78.2615699485
607UbiquitinationIAIISETKSVPSIEP
EEEEECCCCCCCCCC		45.4617644757
616UbiquitinationVPSIEPFKPLSSFNS
CCCCCCCCCHHHCCC		56.6217644757
623PhosphorylationKPLSSFNSFGQEIQN
CCHHHCCCCCHHHHC		28.8321440633
631UbiquitinationFGQEIQNKEPTPLNQ
CCHHHHCCCCCCCCC		49.0117644757
646UbiquitinationTPTDLIGKQRNCVNP
CCCHHHCCCCCCCCC		38.8124961812
659PhosphorylationNPHSIPFSVLSSNSQ
CCCCCCCEEECCCCC		19.4529734811
663PhosphorylationIPFSVLSSNSQSSQS
CCCEEECCCCCCCCC		36.0229734811
665PhosphorylationFSVLSSNSQSSQSGS
CEEECCCCCCCCCCC		33.1329734811
711UbiquitinationEHNFIEEKRSIKNLG
CCCHHHHHHCHHCCC		38.3623749301
715UbiquitinationIEEKRSIKNLGHGPP
HHHHHCHHCCCCCCC		47.5723749301
723PhosphorylationNLGHGPPSQKNNYSF
CCCCCCCCCCCCCCC		57.8530377154
734UbiquitinationNYSFPRNKNTPSNRH
CCCCCCCCCCCCCCC		64.5817644757
751UbiquitinationDFNTIYEKRDGKMVE
CHHHEEECCCCCEEE		38.5317644757
807UbiquitinationEILGMCDKTADDAKR
HHHHCCCCCHHHHHH		40.4617644757
813UbiquitinationDKTADDAKRIIYQLV
CCCHHHHHHHHHHHH		51.6417644757
823UbiquitinationIYQLVNEKHKFSEKG
HHHHHHHHHCCCCCC		47.0617644757
860UbiquitinationGNSLIPNKYQSSIHN
CCCCCCCCHHHCCCC		39.0317644757
874UbiquitinationNDIPSHRKLK-----
CCCCCCCCCC-----		56.0317644757
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FIR1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FIR1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FIR1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PRI1_YEASTPRI1genetic
8668138
SYDC_YEASTDPS1genetic
19061648
NOP16_YEASTNOP16genetic
19061648
CSK22_YEASTCKA2genetic
19061648
SWC5_YEASTSWC5genetic
20093466
SGF29_YEASTSGF29genetic
20093466
YD180_YEASTYDL180Wgenetic
20093466
CYK3_YEASTCYK3genetic
20093466
NHP10_YEASTNHP10genetic
20093466
PAA1_YEASTPAA1genetic
20093466
SWI5_YEASTSWI5genetic
20093466
SSD1_YEASTSSD1genetic
20093466
SHE9_YEASTSHE9genetic
20093466
ZRT1_YEASTZRT1genetic
20093466
VAM7_YEASTVAM7genetic
20093466
DBF2_YEASTDBF2genetic
20093466
SMI1_YEASTSMI1genetic
20093466
FMC1_YEASTFMC1genetic
20093466
SDS3_YEASTSDS3genetic
20093466
DCOR_YEASTSPE1genetic
20093466
MMS22_YEASTMMS22genetic
20093466
FKS1_YEASTFKS1genetic
20093466
TSA1_YEASTTSA1genetic
20093466
PFKA2_YEASTPFK2genetic
20093466
MRE11_YEASTMRE11genetic
20093466
EOS1_YEASTEOS1genetic
20093466
TPM1_YEASTTPM1genetic
20093466
IRA2_YEASTIRA2genetic
20093466
VAM3_YEASTVAM3genetic
20093466
VPH1_YEASTVPH1genetic
20093466
YAR1_YEASTYAR1genetic
20093466
AIM44_YEASTAIM44genetic
20093466
HSP7F_YEASTSSE1genetic
20093466
YP066_YEASTRGL1genetic
20093466
RTC6_YEASTRTC6genetic
20691087
STE50_YEASTSTE50genetic
27708008
XRN1_YEASTXRN1genetic
27708008
KPC1_YEASTPKC1genetic
27708008
APC11_YEASTAPC11genetic
27708008
MPS1_YEASTMPS1genetic
27708008
ACT_YEASTACT1genetic
27708008
PSB1_YEASTPRE3genetic
27708008
ETR1_YEASTETR1genetic
27708008
SGF29_YEASTSGF29genetic
27708008
NHP10_YEASTNHP10genetic
27708008
PP2C1_YEASTPTC1genetic
27708008
SLX5_YEASTSLX5genetic
27708008
CYK3_YEASTCYK3genetic
27708008
YD180_YEASTYDL180Wgenetic
27708008
PAA1_YEASTPAA1genetic
27708008
VPS41_YEASTVPS41genetic
27708008
SWI5_YEASTSWI5genetic
27708008
MDM34_YEASTMDM34genetic
27708008
DBF2_YEASTDBF2genetic
27708008
ASK10_YEASTASK10genetic
27708008
SMI1_YEASTSMI1genetic
27708008
SDS3_YEASTSDS3genetic
27708008
FMC1_YEASTFMC1genetic
27708008
HPM1_YEASTHPM1genetic
27708008
ELM1_YEASTELM1genetic
27708008
FKS1_YEASTFKS1genetic
27708008
UBX2_YEASTUBX2genetic
27708008
TSA1_YEASTTSA1genetic
27708008
PFKA2_YEASTPFK2genetic
27708008
MRE11_YEASTMRE11genetic
27708008
TPM1_YEASTTPM1genetic
27708008
IRA2_YEASTIRA2genetic
27708008
VPH1_YEASTVPH1genetic
27708008
SUR1_YEASTSUR1genetic
27708008
YP066_YEASTRGL1genetic
27708008
HSP7F_YEASTSSE1genetic
27708008
AIM44_YEASTAIM44genetic
27708008
CSR2_YEASTCSR2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FIR1_YEAST

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Related Literatures of Post-Translational Modification

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