NOP16_YEAST - dbPTM
NOP16_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NOP16_YEAST
UniProt AC P40007
Protein Name Nucleolar protein 16
Gene Name NOP16
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 231
Subcellular Localization Nucleus, nucleolus .
Protein Description Involved in the biogenesis of the 60S ribosomal subunit..
Protein Sequence MTSVRKRKMNRSSVGKATRRNKDKQRKINIQSNPIIAANWDYSLTMAQNYKKLGLRAKLQTPAGGKEADLSKVVKRIPLTKPVLDEDEDEDEGEDEQNDYNAATVELDENEIPEGGARIQRDKNGDVVRVVYGKKKNFDADEDVNEIKARDTTEETEVVKKLEELASRPVIRKERSQSEREEEWLEKLYKKHGDDYKKMFFDKKLNIYQQSEGDLKRRLLRWKKRNGIASK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
12PhosphorylationRKRKMNRSSVGKATR
HHHCCCHHHHHHHHH		25.1127717283
13PhosphorylationKRKMNRSSVGKATRR
HHCCCHHHHHHHHHC		31.4827717283
58AcetylationKKLGLRAKLQTPAGG
HHHCCEEEEECCCCC		34.3925381059
61PhosphorylationGLRAKLQTPAGGKEA
CCEEEEECCCCCCCC		26.0823749301
66AcetylationLQTPAGGKEADLSKV
EECCCCCCCCCHHHH		49.1324489116
72AcetylationGKEADLSKVVKRIPL
CCCCCHHHHHHHCCC		59.3422865919
134AcetylationVVRVVYGKKKNFDAD
EEEEEEECCCCCCCC		42.7725381059
135AcetylationVRVVYGKKKNFDADE
EEEEEECCCCCCCCC		48.8925381059
136AcetylationRVVYGKKKNFDADED
EEEEECCCCCCCCCC		67.3525381059
152PhosphorylationNEIKARDTTEETEVV
HHHHCCCCCHHHHHH		30.4722369663
153PhosphorylationEIKARDTTEETEVVK
HHHCCCCCHHHHHHH		35.7923749301
156PhosphorylationARDTTEETEVVKKLE
CCCCCHHHHHHHHHH		28.0422369663
160AcetylationTEETEVVKKLEELAS
CHHHHHHHHHHHHHC		57.7425381059
161AcetylationEETEVVKKLEELASR
HHHHHHHHHHHHHCC		49.9024489116
176PhosphorylationPVIRKERSQSEREEE
CCCCCCCCHHHHHHH		38.8725521595
178PhosphorylationIRKERSQSEREEEWL
CCCCCCHHHHHHHHH		39.6125521595
187AcetylationREEEWLEKLYKKHGD
HHHHHHHHHHHHHCC		55.7524489116
196PhosphorylationYKKHGDDYKKMFFDK
HHHHCCHHHHHHHHH		19.7627017623
208PhosphorylationFDKKLNIYQQSEGDL
HHHHCCEEECCHHHH		10.2230377154
211PhosphorylationKLNIYQQSEGDLKRR
HCCEEECCHHHHHHH		28.2030377154
216AcetylationQQSEGDLKRRLLRWK
ECCHHHHHHHHHHHH		39.9724489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NOP16_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NOP16_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NOP16_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
BRX1_YEASTBRX1physical
18467557
UBI4P_YEASTUBI4genetic
19061648
MRH4_YEASTMRH4genetic
19061648
NOP12_YEASTNOP12genetic
19061648
EIF3J_YEASTHCR1genetic
19061648
RRP8_YEASTRRP8genetic
19061648
LTV1_YEASTLTV1genetic
19061648
CHD1_YEASTCHD1genetic
19547744
UBC4_YEASTUBC4genetic
20093466
ZRC1_YEASTZRC1genetic
20093466
REXO4_YEASTREX4genetic
20093466
YP089_YEASTYPR089Wgenetic
20093466
BRX1_YEASTBRX1physical
22615397
LOC1_YEASTLOC1physical
25877921
MAK21_YEASTMAK21physical
25877921
EBP2_YEASTEBP2physical
25877921
NOP4_YEASTNOP4physical
25877921
UBC4_YEASTUBC4genetic
27708008
TPS1_YEASTTPS1genetic
27708008
YBY9_YEASTYBR139Wgenetic
27708008
UME6_YEASTUME6genetic
27708008
MED5_YEASTNUT1genetic
27708008
RMR1_YEASTRMR1genetic
27708008
RTG2_YEASTRTG2genetic
27708008
RL26B_YEASTRPL26Bgenetic
27708008
PEX8_YEASTPEX8genetic
27708008
PDC6_YEASTPDC6genetic
27708008
MED20_YEASTSRB2genetic
27708008
SSF1_YEASTSSF1genetic
27708008
PIR5_YEASTYJL160Cgenetic
27708008
IMA5_YEASTIMA5genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
SAC1_YEASTSAC1genetic
27708008
MMM1_YEASTMMM1genetic
27708008
CHA4_YEASTCHA4genetic
27708008
GBLP_YEASTASC1genetic
27708008
ZRC1_YEASTZRC1genetic
27708008
TMA23_YEASTTMA23genetic
27708008
SPO1_YEASTSPO1genetic
27708008
YNE0_YEASTYNL040Wgenetic
27708008
REXO4_YEASTREX4genetic
27708008
RRP6_YEASTRRP6genetic
27708008
YP089_YEASTYPR089Wgenetic
27708008
NOP4_YEASTNOP4physical
27077951
RL36A_YEASTRPL36Agenetic
29158977
MAK5_YEASTMAK5genetic
29674565
SSF1_YEASTSSF1genetic
29674565
MDM10_YEASTMDM10genetic
29674565
TCPZ_YEASTCCT6genetic
29674565
MAK16_YEASTMAK16genetic
29674565
CND2_YEASTBRN1genetic
29674565
CSG2_YEASTCSG2genetic
29674565
RS14A_YEASTRPS14Agenetic
29674565
SLX5_YEASTSLX5genetic
29674565
VAM6_YEASTVAM6genetic
29674565
TAF12_YEASTTAF12genetic
29674565
ERF3_YEASTSUP35genetic
29674565
DHSD_YEASTSDH4genetic
29674565
TCPA_YEASTTCP1genetic
29674565
FCF1_YEASTFCF1genetic
29674565
DBP3_YEASTDBP3genetic
29674565
VAM7_YEASTVAM7genetic
29674565
RPF1_YEASTRPF1genetic
29674565
VPS24_YEASTVPS24genetic
29674565
NOC3_YEASTNOC3genetic
29674565
POC3_YEASTIRC25genetic
29674565
RSSA2_YEASTRPS0Bgenetic
29674565
SIC1_YEASTSIC1genetic
29674565
PFD6_YEASTYKE2genetic
29674565
DBP9_YEASTDBP9genetic
29674565
PHO80_YEASTPHO80genetic
29674565
RRP44_YEASTDIS3genetic
29674565
NOP12_YEASTNOP12genetic
29674565
BRX1_YEASTBRX1genetic
29674565
REXO4_YEASTREX4genetic
29674565
BUB3_YEASTBUB3genetic
29674565
VPS5_YEASTVPS5genetic
29674565
APC5_YEASTAPC5genetic
29674565
SUR1_YEASTSUR1genetic
29674565
GLU2A_YEASTROT2genetic
29674565
NUM1_YEASTNUM1genetic
29674565
RTG2_YEASTRTG2genetic
29674565
RPN10_YEASTRPN10genetic
29674565
ELM1_YEASTELM1genetic
29674565
SPA2_YEASTSPA2genetic
29674565
YPT7_YEASTYPT7genetic
29674565
PSP2_YEASTPSP2genetic
29674565
NEW1_YEASTNEW1genetic
29674565
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NOP16_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-176, AND MASSSPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-176 AND SER-178, ANDMASS SPECTROMETRY.

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