| UniProt ID | BRX1_YEAST | |
|---|---|---|
| UniProt AC | Q08235 | |
| Protein Name | Ribosome biogenesis protein BRX1 | |
| Gene Name | BRX1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 291 | |
| Subcellular Localization | Nucleus, nucleolus . | |
| Protein Description | Required for biogenesis of the 60S ribosomal subunit.. | |
| Protein Sequence | MSSIYKALAGKSKDNKSEKKQGNVKQFMNKQRTLLISSRGVNYRHRHLIQDLSGLLPHSRKEPKLDTKKDLQQLNEIAELYNCNNVLFFEARKHQDLYLWLSKPPNGPTIKFYIQNLHTMDELNFTGNCLKGSRPVLSFDQRFESSPHYQLIKELLVHNFGVPPNARKSKPFIDHVMSFSIVDDKIWVRTYEISHSTKNKEEYEDGEEDISLVEIGPRFVMTVILILEGSFGGPKIYENKQYVSPNVVRAQIKQQAAEEAKSRAEAAVERKIKRRENVLAADPLSNDALFK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 6 | Acetylation | --MSSIYKALAGKSK --CCHHHHHHCCCCC | 34.94 | 22865919 | |
| 11 | Acetylation | IYKALAGKSKDNKSE HHHHHCCCCCCCCCH | 49.04 | 25381059 | |
| 98 | Phosphorylation | ARKHQDLYLWLSKPP EECCCCEEEEECCCC | 12.24 | 27017623 | |
| 109 | Phosphorylation | SKPPNGPTIKFYIQN CCCCCCCCEEEEEEC | 37.89 | 27017623 | |
| 200 | Acetylation | ISHSTKNKEEYEDGE EEECCCCHHHCCCCC | 54.18 | 24489116 | |
| 240 | Acetylation | GPKIYENKQYVSPNV CCHHHCCCCCCCHHH | 30.94 | 24489116 | |
| 240 | Succinylation | GPKIYENKQYVSPNV CCHHHCCCCCCCHHH | 30.94 | 23954790 | |
| 285 | Phosphorylation | VLAADPLSNDALFK- CCCCCCCCCCCCCC- | 37.74 | 19823750 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of BRX1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of BRX1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of BRX1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-285, AND MASSSPECTROMETRY. | |
