| UniProt ID | DBP10_YEAST | |
|---|---|---|
| UniProt AC | Q12389 | |
| Protein Name | ATP-dependent RNA helicase DBP10 | |
| Gene Name | DBP10 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 995 | |
| Subcellular Localization | Nucleus, nucleolus . | |
| Protein Description | ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.. | |
| Protein Sequence | MAGVQKRKRDLEDQDDNGSEEDDIAFDIANEIALNDSESDANDSDSEVEADYGPNDVQDVIEYSSDEEEGVNNKKKAENKDIKKKKNSKKEIAAFPMLEMSDDENNASGKTQTGDDEDDVNEYFSTNNLEKTKHKKGSFPSFGLSKIVLNNIKRKGFRQPTPIQRKTIPLILQSRDIVGMARTGSGKTAAFILPMVEKLKSHSGKIGARAVILSPSRELAMQTFNVFKDFARGTELRSVLLTGGDSLEEQFGMMMTNPDVIIATPGRFLHLKVEMNLDLKSVEYVVFDEADRLFEMGFQEQLNELLASLPTTRQTLLFSATLPNSLVDFVKAGLVNPVLVRLDAETKVSENLEMLFLSSKNADREANLLYILQEIIKIPLATSEQLQKLQNSNNEADSDSDDENDRQKKRRNFKKEKFRKQKMPAANELPSEKATILFVPTRHHVEYISQLLRDCGYLISYIYGTLDQHARKRQLYNFRAGLTSILVVTDVAARGVDIPMLANVINYTLPGSSKIFVHRVGRTARAGNKGWAYSIVAENELPYLLDLELFLGKKILLTPMYDSLVDVMKKRWIDEGKPEYQFQPPKLSYTKRLVLGSCPRLDVEGLGDLYKNLMSSNFDLQLAKKTAMKAEKLYYRTRTSASPESLKRSKEIISSGWDAQNAFFGKNEEKEKLDFLAKLQNRRNKETVFEFTRNPDDEMAVFMKRRRKQLAPIQRKATERRELLEKERMAGLSHSIEDEILKGDDGETGYTVSEDALKEFEDADQLLEAQENENKKKKKPKSFKDPTFFLSHYAPAGDIQDKQLQITNGFANDAAQAAYDLNSDDKVQVHKQTATVKWDKKRKKYVNTQGIDNKKYIIGESGQKIAASFRSGRFDDWSKARNLKPLKVGSRETSIPSNLLEDPSQGPAANGRTVRGKFKHKQMKAPKMPDKHRDNYYSQKKKVEKALQSGISVKGYNNAPGLRSELKSTEQIRKDRIIAEKKRAKNARPSKKRKF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 6 | Acetylation | --MAGVQKRKRDLED --CCCCCCCCCCCCC | 58.44 | 25381059 | |
| 76 | Acetylation | EGVNNKKKAENKDIK CCCCCHHHHCCCHHH | 63.64 | 23572591 | |
| 101 | Phosphorylation | AFPMLEMSDDENNAS HEEEEECCCCCCCCC | 32.32 | 22369663 | |
| 108 | Phosphorylation | SDDENNASGKTQTGD CCCCCCCCCCCCCCC | 42.84 | 22890988 | |
| 111 | Phosphorylation | ENNASGKTQTGDDED CCCCCCCCCCCCCHH | 34.58 | 22369663 | |
| 113 | Phosphorylation | NASGKTQTGDDEDDV CCCCCCCCCCCHHHH | 48.05 | 22369663 | |
| 125 | Phosphorylation | DDVNEYFSTNNLEKT HHHHHHHHCCCHHHC | 29.35 | 21551504 | |
| 131 | Acetylation | FSTNNLEKTKHKKGS HHCCCHHHCCCCCCC | 67.07 | 24489116 | |
| 392 | Phosphorylation | QLQKLQNSNNEADSD HHHHHHHCCCCCCCC | 28.24 | 22890988 | |
| 398 | Phosphorylation | NSNNEADSDSDDEND HCCCCCCCCCCCHHH | 46.17 | 25521595 | |
| 400 | Phosphorylation | NNEADSDSDDENDRQ CCCCCCCCCCHHHHH | 51.41 | 25521595 | |
| 563 | Phosphorylation | LLTPMYDSLVDVMKK HHHHCCHHHHHHHHH | 16.89 | 20377248 | |
| 626 | Phosphorylation | DLQLAKKTAMKAEKL CHHHHHHHHHHHHHH | 31.14 | 19795423 | |
| 640 | Phosphorylation | LYYRTRTSASPESLK HHHHHCCCCCHHHHH | 24.37 | 21440633 | |
| 642 | Phosphorylation | YRTRTSASPESLKRS HHHCCCCCHHHHHHH | 29.03 | 23749301 | |
| 670 | Acetylation | FFGKNEEKEKLDFLA HCCCCHHHHHHHHHH | 54.71 | 25381059 | |
| 672 | Acetylation | GKNEEKEKLDFLAKL CCCHHHHHHHHHHHH | 65.51 | 24489116 | |
| 678 | Acetylation | EKLDFLAKLQNRRNK HHHHHHHHHHHCCCC | 53.40 | 24489116 | |
| 733 | Phosphorylation | KERMAGLSHSIEDEI HHHHHCCCCCHHHHH | 17.80 | 30377154 | |
| 735 | Phosphorylation | RMAGLSHSIEDEILK HHHCCCCCHHHHHHC | 25.05 | 30377154 | |
| 753 | Phosphorylation | GETGYTVSEDALKEF CCCCEECCHHHHHHC | 23.20 | 21551504 | |
| 784 | Acetylation | KKKPKSFKDPTFFLS CCCCCCCCCCCHHHH | 70.64 | 24489116 | |
| 819 | Phosphorylation | NDAAQAAYDLNSDDK CHHHHHHHHCCCCCC | 24.79 | 21440633 | |
| 823 | Phosphorylation | QAAYDLNSDDKVQVH HHHHHCCCCCCEEEE | 55.26 | 21440633 | |
| 837 | Acetylation | HKQTATVKWDKKRKK EEEEEEEECCHHCHH | 45.37 | 25381059 | |
| 868 | Phosphorylation | SGQKIAASFRSGRFD CCCCHHHHHHCCCCC | 16.51 | 21126336 | |
| 890 | Phosphorylation | LKPLKVGSRETSIPS CCCCCCCCCCCCCCC | 29.90 | 21440633 | |
| 893 | Phosphorylation | LKVGSRETSIPSNLL CCCCCCCCCCCCCCC | 30.74 | 21440633 | |
| 894 | Phosphorylation | KVGSRETSIPSNLLE CCCCCCCCCCCCCCC | 27.96 | 27017623 | |
| 940 | Acetylation | RDNYYSQKKKVEKAL CCCCHHHHHHHHHHH | 48.93 | 25381059 | |
| 949 | Phosphorylation | KVEKALQSGISVKGY HHHHHHHCCCCCCCC | 38.66 | 28889911 | |
| 952 | Phosphorylation | KALQSGISVKGYNNA HHHHCCCCCCCCCCC | 22.69 | 30377154 | |
| 968 | Phosphorylation | GLRSELKSTEQIRKD CHHHHHHCHHHHHHH | 50.21 | 30377154 | |
| 969 | Phosphorylation | LRSELKSTEQIRKDR HHHHHHCHHHHHHHH | 30.26 | 30377154 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DBP10_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DBP10_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DBP10_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-101; SER-398 ANDSER-400, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-398 AND SER-400, ANDMASS SPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-101, AND MASSSPECTROMETRY. | |
| "Phosphoproteome analysis by mass spectrometry and its application toSaccharomyces cerevisiae."; Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M.,Shabanowitz J., Hunt D.F., White F.M.; Nat. Biotechnol. 20:301-305(2002). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-398 AND SER-400, ANDMASS SPECTROMETRY. | |
