| UniProt ID | TCD2_YEAST | |
|---|---|---|
| UniProt AC | P36101 | |
| Protein Name | tRNA threonylcarbamoyladenosine dehydratase 2 | |
| Gene Name | TCD2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 447 | |
| Subcellular Localization |
Mitochondrion outer membrane Multi-pass membrane protein . |
|
| Protein Description | Catalyzes the ATP-dependent dehydration of threonylcarbamoyladenosine at position 37 (t(6)A37) to form cyclic t(6)A37 (ct(6)A37) in tRNAs that read codons beginning with adenine.. | |
| Protein Sequence | MVEKDTWKLITATALFTVAVTTITDYAWTSWQAQKQVIAQQKNKNKGGQTKSDTDKYHQYDEQFIRQSLKNNVEFLGEDTIEKLSNQYVVVVGAGGVGSWVVNSLVRSGCRKIRVVDFDQVSLSSLNRHSCAILNDVGTPKVECLRRHMREIAPWCEIDPINELWTLQNGERLTLGNGTPDFIVDCIDNIDTKVDLLEFAYNHGIKVISSMGASAKSDPTKLNVGDLATTEEDPLARVVRRKLKKRGILSGIPVVFSAEKPDPKKAKLLPLPDEEYERGKVDELSALKDFRVRILPVLGTMPSLFGLTITTWILSNISDKPLEPVEGKNRIKVYDGIYQSLAGQMSRVGIPSQRIPLALKDVSYLVEEVFKGKSPISGISTRLTLTKWDPSKPISLQNVVVLTKNEQKVHEDRVLKGKESLQDVYDAKVLKLVSQRFREEAYYSQFR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 50 | Phosphorylation | NKNKGGQTKSDTDKY CCCCCCCCCCCHHHH | 22369663 | ||
| 52 | Phosphorylation | NKGGQTKSDTDKYHQ CCCCCCCCCHHHHHH | 22369663 | ||
| 54 | Phosphorylation | GGQTKSDTDKYHQYD CCCCCCCHHHHHHHC | 22369663 | ||
| 56 | Acetylation | QTKSDTDKYHQYDEQ CCCCCHHHHHHHCHH | 24489116 | ||
| 57 | Phosphorylation | TKSDTDKYHQYDEQF CCCCHHHHHHHCHHH | 22369663 | ||
| 60 | Phosphorylation | DTDKYHQYDEQFIRQ CHHHHHHHCHHHHHH | 19823750 | ||
| 68 | Phosphorylation | DEQFIRQSLKNNVEF CHHHHHHHHHHCCEE | 19823750 | ||
| 141 | Ubiquitination | LNDVGTPKVECLRRH ECCCCCCHHHHHHHH | 17644757 | ||
| 209 | Phosphorylation | NHGIKVISSMGASAK HCCCEEEECCCCCCC | 19779198 | ||
| 210 | Phosphorylation | HGIKVISSMGASAKS CCCEEEECCCCCCCC | 19779198 | ||
| 221 | Ubiquitination | SAKSDPTKLNVGDLA CCCCCCCCCCHHHCC | 23749301 | ||
| 230 | Phosphorylation | NVGDLATTEEDPLAR CHHHCCCCCCCHHHH | 19779198 | ||
| 260 | Ubiquitination | PVVFSAEKPDPKKAK CEEEECCCCCCCCCC | 17644757 | ||
| 264 | Ubiquitination | SAEKPDPKKAKLLPL ECCCCCCCCCCCCCC | 17644757 | ||
| 265 | Ubiquitination | AEKPDPKKAKLLPLP CCCCCCCCCCCCCCC | 17644757 | ||
| 420 | Phosphorylation | RVLKGKESLQDVYDA HCCCCCHHHHHHHHH | 25704821 | ||
| 428 | Acetylation | LQDVYDAKVLKLVSQ HHHHHHHHHHHHHHH | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TCD2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TCD2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TCD2_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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