dbPTM

TRM11_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TRM11_YEAST
UniProt AC	Q12463
Protein Name	tRNA (guanine(10)-N2)-methyltransferase
Gene Name	TRM11
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	433
Subcellular Localization	Cytoplasm .
Protein Description	Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs..
Protein Sequence	MKKYLLYMVQVHLNFRRAELESLADLYNLSIDFSQYDANSPFFIVELENDQQAKDWIKRSILTRGIYEYWGQGTTLDELHKDIQRQSNFEQDLQLKFKHSTFKFEFECYKGNSKAKRVEQIETFRYLGFEGKIDMKHPQEVFTVIEEYTPISENVGGKTPTRIYFGRQVQMSNRSAMEKYDLKKRPYKGTTSFEAELSLVSANIAQVKPGTIMYDPFAGTGSFLVAGGHFGSLVIGSDIDGRMIRGKGAQVNISANFKKYGESSQFLDVLTMDFTNNALRNNLVIDTILCDPPYGIRESIKVLGAKDPERFLGKEDMEIDGEKAYLRRDYIPTKKPYALDSLLDDLLQYSSERLPIGGRLAFWMPTANDANIETIVPMHENLELKYNCVQEFNKWSRRLLVYINRGSTFNGSSNHGIKRSKDNFRERYFNNFN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
96	Acetylation	FEQDLQLKFKHSTFK CCHHHHHHHCCCEEE	39.13	24489116
314	Acetylation	DPERFLGKEDMEIDG CHHHHCCCCCCEECC	53.33	24489116

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TRM11_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TRM11_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TRM11_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TR112_YEAST	TRM112	physical	16429126
TRM10_YEAST	TRM10	genetic	19061648
SYNC_YEAST	DED81	genetic	19061648
TR112_YEAST	TRM112	physical	15899842
DAL81_YEAST	DAL81	genetic	27708008
THI73_YEAST	THI73	genetic	27708008
GIS3_YEAST	GIS3	genetic	27708008
ENT2_YEAST	ENT2	genetic	27708008
PP2B1_YEAST	CNA1	genetic	27708008
ELOC_YEAST	ELC1	genetic	27708008
SSU1_YEAST	SSU1	genetic	27708008
GPR1_YEAST	GPR1	genetic	27708008
PEX19_YEAST	PEX19	genetic	27708008
TRM1_YEAST	TRM1	genetic	27708008
SAC3_YEAST	SAC3	genetic	27708008
SEM1_YEAST	SEM1	genetic	27708008
TCD1_YEAST	TCD1	genetic	27708008
MED20_YEAST	SRB2	genetic	27708008
RPA34_YEAST	RPA34	genetic	27708008
UBI4P_YEAST	UBI4	genetic	27708008
ENV10_YEAST	ENV10	genetic	27708008
NU188_YEAST	NUP188	genetic	27708008
RIM11_YEAST	RIM11	genetic	27708008
RAD14_YEAST	RAD14	genetic	27708008
SCS7_YEAST	SCS7	genetic	27708008
CAT8_YEAST	CAT8	genetic	27708008
PMS1_YEAST	PMS1	genetic	27708008
NM111_YEAST	NMA111	genetic	27708008
KC12_YEAST	YCK2	genetic	27708008
RCN2_YEAST	RCN2	genetic	27708008
MRX11_YEAST	YPL041C	genetic	27708008
WDR6_YEAST	RTT10	genetic	27708008
TR112_YEAST	TRM112	physical	27986851

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TRM11_YEAST

Related Literatures of Post-Translational Modification