CAT8_YEAST - dbPTM
CAT8_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CAT8_YEAST
UniProt AC P39113
Protein Name Regulatory protein CAT8
Gene Name CAT8
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1433
Subcellular Localization Nucleus.
Protein Description Activator of the gluconeogenic enzymes FBP1 and PCK1 genes..
Protein Sequence MANNNSDRQGLEPRVIRTLGSQALSGPSISNRTSSSEANPHFSKNVKEAMIKTASPTPLSTPIYRIAQACDRCRSKKTRCDGKRPQCSQCAAVGFECRISDKLLRKAYPKGYTESLEERVRELEAENKRLLALCDIKEQQISLVSQSRPQTSTDNTINGNFKHDLKDAPLNLSSTNIYLLNQTVNKQLQNGKMDGDNSGSAMSPLGAPPPPPHKDHLCDGVSCTNHLHVKPTSTSLNDPTAISFEQDEAPGLPAVKALKSMTTHQRSTQLATLVSLSIPRSTEEILFIPQLLTRIRQIFGFNSKQCLYTVSLLSSLKNRLPAPRLLAPSTSTKLKEKDEDKKLDDDSAFVKRFQSTNLSEFVDLKKFLISLKFNINSFSKQSEKPANDQDDELLSLTEIKELLHLFFKFWSNQVPILNNDHFLIYFNNFVEVVKHLSTENLETNNTTKSTVTTNHEIFALKLLMMLQMGLLVKIKMEKIKYTVPKNPKAKYARLMAYYHQLSLIIPKNPYFLNMSTTSLPSLQLLSLASFYYLNVGDISAIYGVRGRIVSMAQQLRLHRCPSAVLSVHSNPVLQKFEQSERRLLFWAIYYVDVFASLQLGVPRLLKDFDIECALPISDVEYKDQLSMENEKADKKAKKIQLQGQVSSFSLQIIRFAKILGNILDSIFKRGMMDERITSEVALVHENALDNWRNQLPEMYYFQITVNGTVNLDEIRATNQRNTETKFDKKDIILFEKKILLLFYFLAKSMIHLPVIATKPLPKNVDNATKKKQSMFNNDSKGATNQDHMILDVDMTSPAIRTSSSYIILQQATNATLTIFQAINSMYLPLPLNVSRTLIRFSLLCARGSLEYTKGGALFLDNKNLLLDTIKDIENDRLLDLPGIASWHTLKLFDMSINLLLKAPNVKVERLDKFLEKKLNYYNRLMGLPPATTTSLKPLFGSQSKNSLENRQRTPNVKRENPEHEYLYGNDSNNNNNSEAGHSPMTNTTNGNKRLKYEKDAKRNAKDGGISKGENAHNFQNDTKKNMSTSNLFPFSFSNTDLTALFTHPEGPNCTNTNNGNVDVCNRASTDATDANIENLSFLNMAPFLQTGNSNIGQNTIENKPMHMDAIFSLPSNLDLMKDNMDSKPEQLEPVIKQNPENSKNNQFHQKGKSTNMEKNNLSFNNKSNYSLTKLMRLLNNDNSFSNISINNFLYQNDQNSASADPGTNKKAVTNAGANFKPPSTGSNTSQGSILGSTKHGMDNCDFNDLGNFNNFMTNVNYSGVDYDYIVDASLGLAPLLVDTPDISNTNTTSTTSNRSKNSIILDTTFNDDLDRSRMNAREVLNPTDSILSQGMVSSVSTRNTSNQRSLSSGNDSKGDSSSQENSKSATGNQLDTPSTLFQMRRTSSGPSASHRGPRRPQKNRYNTDRSKSSGGGSSNTDNVSDLFQWQNAK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
25PhosphorylationTLGSQALSGPSISNR
HHCHHHHCCCCCCCC		52.2330377154
28PhosphorylationSQALSGPSISNRTSS
HHHHCCCCCCCCCCC		42.0230377154
30PhosphorylationALSGPSISNRTSSSE
HHCCCCCCCCCCCCC		25.2919779198
35PhosphorylationSISNRTSSSEANPHF
CCCCCCCCCCCCCCC		31.4227214570
43PhosphorylationSEANPHFSKNVKEAM
CCCCCCCCCCHHHHH		21.9319779198
53PhosphorylationVKEAMIKTASPTPLS
HHHHHHHHCCCCCCC		22.8028889911
55PhosphorylationEAMIKTASPTPLSTP
HHHHHHCCCCCCCCH		34.2429136822
113PhosphorylationKAYPKGYTESLEERV
HHCCCCCCHHHHHHH		27.9730377154
147PhosphorylationQISLVSQSRPQTSTD
HEEEEECCCCCCCCC		38.1227214570
173PhosphorylationKDAPLNLSSTNIYLL
CCCCCCCCCCEEEEE		33.7621440633
174PhosphorylationDAPLNLSSTNIYLLN
CCCCCCCCCEEEEEE		28.7421440633
175PhosphorylationAPLNLSSTNIYLLNQ
CCCCCCCCEEEEEEH		23.4321440633
203PhosphorylationDNSGSAMSPLGAPPP
CCCCCCCCCCCCCCC		19.3829734811
329PhosphorylationAPRLLAPSTSTKLKE
CCCCCCCCCCCCCCC		29.4130377154
332PhosphorylationLLAPSTSTKLKEKDE
CCCCCCCCCCCCCCC		40.2519779198
370PhosphorylationDLKKFLISLKFNINS
CHHHHHHHHHCCCCC		27.8828889911
377PhosphorylationSLKFNINSFSKQSEK
HHHCCCCCCCCCCCC		27.4028889911
379PhosphorylationKFNINSFSKQSEKPA
HCCCCCCCCCCCCCC		29.6128889911
481PhosphorylationIKMEKIKYTVPKNPK
HHHHHCCCCCCCCHH		19.2219779198
562PhosphorylationLRLHRCPSAVLSVHS
HHHHCCCCCHHCCCC		34.3428889911
965PhosphorylationRENPEHEYLYGNDSN
CCCCCCCCCCCCCCC		13.7130377154
967PhosphorylationNPEHEYLYGNDSNNN
CCCCCCCCCCCCCCC		17.0029136822
971PhosphorylationEYLYGNDSNNNNNSE
CCCCCCCCCCCCCCC		45.5229136822
977PhosphorylationDSNNNNNSEAGHSPM
CCCCCCCCCCCCCCC		30.8329136822
982PhosphorylationNNSEAGHSPMTNTTN
CCCCCCCCCCCCCCC		18.5627214570
985PhosphorylationEAGHSPMTNTTNGNK
CCCCCCCCCCCCCCC		32.5627214570
987PhosphorylationGHSPMTNTTNGNKRL
CCCCCCCCCCCCCCC		16.6930377154
988PhosphorylationHSPMTNTTNGNKRLK
CCCCCCCCCCCCCCC		43.1030377154
1162PhosphorylationNMEKNNLSFNNKSNY
CHHHCCCCCCCCCCC		28.2230377154
1167PhosphorylationNLSFNNKSNYSLTKL
CCCCCCCCCCHHHHH		43.0221440633
1170PhosphorylationFNNKSNYSLTKLMRL
CCCCCCCHHHHHHHH		33.5425752575
1172PhosphorylationNKSNYSLTKLMRLLN
CCCCCHHHHHHHHHC		19.0521440633
1229PhosphorylationPSTGSNTSQGSILGS
CCCCCCCCCCCCCCC		36.4723749301
1232PhosphorylationGSNTSQGSILGSTKH
CCCCCCCCCCCCCCC		13.6523749301
1337PhosphorylationILSQGMVSSVSTRNT
HHHHCCCCCCCCCCC		19.0119779198
1338PhosphorylationLSQGMVSSVSTRNTS
HHHCCCCCCCCCCCC		14.5319779198
1344PhosphorylationSSVSTRNTSNQRSLS
CCCCCCCCCCCCCCC		26.2627017623
1349PhosphorylationRNTSNQRSLSSGNDS
CCCCCCCCCCCCCCC		23.8828889911
1351PhosphorylationTSNQRSLSSGNDSKG
CCCCCCCCCCCCCCC		37.1323749301
1362PhosphorylationDSKGDSSSQENSKSA
CCCCCCCCCCCCCCC		45.5323749301
1368PhosphorylationSSQENSKSATGNQLD
CCCCCCCCCCCCCCC		30.7729136822
1370PhosphorylationQENSKSATGNQLDTP
CCCCCCCCCCCCCCH		43.7029136822
1376PhosphorylationATGNQLDTPSTLFQM
CCCCCCCCHHHHHHH		27.9429136822
1378PhosphorylationGNQLDTPSTLFQMRR
CCCCCCHHHHHHHHC		39.5729136822
1379PhosphorylationNQLDTPSTLFQMRRT
CCCCCHHHHHHHHCC		32.5629136822
1386PhosphorylationTLFQMRRTSSGPSAS
HHHHHHCCCCCCCCC		19.5130377154
1387PhosphorylationLFQMRRTSSGPSASH
HHHHHCCCCCCCCCC		31.3330377154
1388PhosphorylationFQMRRTSSGPSASHR
HHHHCCCCCCCCCCC		54.8625752575
1420PhosphorylationSGGGSSNTDNVSDLF
CCCCCCCCCCHHHHH		30.7919779198
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CAT8_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CAT8_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CAT8_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CAT8_YEASTCAT8physical
11486018
SIP4_YEASTSIP4physical
11486018
CAT8_YEASTCAT8physical
11967834
SIP4_YEASTSIP4genetic
9843506
ADR1_YEASTADR1genetic
11495982
ESF1_YEASTESF1physical
16554755
STD1_YEASTSTD1physical
11283351
ADR1_YEASTADR1genetic
18197247
AATC_YEASTAAT2genetic
20959818
YP015_YEASTYPR015Cgenetic
20959818
MTH1_YEASTMTH1genetic
21127252
SLT2_YEASTSLT2genetic
21127252
SPR3_YEASTSPR3physical
22875988
RE107_YEASTREC107physical
22875988
CAT8_YEASTCAT8physical
22875988
BMH1_YEASTBMH1genetic
25355315
ADR1_YEASTADR1genetic
25355315
MIG1_YEASTMIG1genetic
27770224
MTU1_YEASTSLM3genetic
27708008
RM49_YEASTMRP49genetic
27708008
SPO1_YEASTSPO1genetic
27708008
HAP3_YEASTHAP3genetic
27708008
SIF2_YEASTSIF2genetic
27708008
HPC2_YEASTHPC2genetic
27708008
SLX5_YEASTSLX5genetic
27708008
S2538_YEASTYDL119Cgenetic
27708008
PEX5_YEASTPEX5genetic
27708008
PEX10_YEASTPEX10genetic
27708008
KC13_YEASTYCK3genetic
27708008
RTR1_YEASTRTR1genetic
27708008
PT122_YEASTPET122genetic
27708008
GCN20_YEASTGCN20genetic
27708008
YFI8_YEASTYFR018Cgenetic
27708008
SGF73_YEASTSGF73genetic
27708008
HOS2_YEASTHOS2genetic
27708008
MDM34_YEASTMDM34genetic
27708008
MTC3_YEASTMTC3genetic
27708008
ASK10_YEASTASK10genetic
27708008
ERC1_YEASTERC1genetic
27708008
COX23_YEASTCOX23genetic
27708008
CSK21_YEASTCKA1genetic
27708008
FLX1_YEASTFLX1genetic
27708008
BLI1_YEASTBLI1genetic
27708008
COX12_YEASTCOX12genetic
27708008
HRT3_YEASTHRT3genetic
27708008
MMR1_YEASTMMR1genetic
27708008
COA4_YEASTCOA4genetic
27708008
TOP3_YEASTTOP3genetic
27708008
LIPB_YEASTLIP2genetic
27708008
PET8_YEASTPET8genetic
27708008
SWS2_YEASTSWS2genetic
27708008
PHO80_YEASTPHO80genetic
27708008
IZH2_YEASTIZH2genetic
27708008
RTG1_YEASTRTG1genetic
27708008
RRP6_YEASTRRP6genetic
27708008
CY1_YEASTCYT1genetic
27708008
COQ7_YEASTCAT5genetic
27708008
LIPA_YEASTLIP5genetic
27708008
MNE1_YEASTMNE1genetic
27708008
BRR1_YEASTBRR1genetic
27708008
ADR1_YEASTADR1genetic
28373292
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CAT8_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-173; THR-175 ANDSER-1170, AND MASS SPECTROMETRY.

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