HRT3_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HRT3_YEAST
• UniProt AC: Q12347
• Protein Name: F-box protein HRT3
• Gene Name: HRT3
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 344
• Protein Description: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity)..
• Protein Sequence: MIVDYEKDPRAKEAIAIWEKGVLKEKDGSMSDAINFYRSALKIHDNVESLYRKKILDEWMLHKKLSGLSMTTDAPDEQNETGKDDLSVEENAELQPCWILEILPDDILLRIIKKVILMSGESWVNLSMTCSTFSKLCFHDSVPFKTFAKYIYSKQIYDKMAMDLNGITDINTFEKEIWRGDDYRMLRERPYIKFEGVYISVVNYVRYGSNAESSLSLLKPVHMITYYRYFRFYENGQCLRLLSTDEPSAVVKHFSKENKPRHSHMCYWSLGFDYDFGHLKITRSDEKYTFIEEFQIKNQGNKRYQRLKWLSSIVVDKEGNASNCSLRNEKSFFFSRVKSFKDPG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	Phosphorylation	VLKEKDGSMSDAINF CEEECCCCHHHHHHH	25.83	27017623
37	Phosphorylation	MSDAINFYRSALKIH HHHHHHHHHHHHHHC	10.12	27017623

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	HRT3	Q12347	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HRT3_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HRT3_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SKP1_YEAST	SKP1	physical	11805837
UBI4P_YEAST	UBI4	physical	11805837
GUF1_YEAST	GUF1	physical	11805837
ADH2_YEAST	ADH2	physical	11805837
IDH1_YEAST	IDH1	physical	11805837
CDC53_YEAST	CDC53	physical	11805837
CDC53_YEAST	CDC53	physical	10582239
SKP1_YEAST	SKP1	physical	10582239
TXTP_YEAST	CTP1	genetic	20093466
CG23_YEAST	CLB3	genetic	20093466
SLX5_YEAST	SLX5	genetic	20093466
SC6B1_YEAST	SBH1	genetic	20093466
SCS2_YEAST	SCS2	genetic	20093466
PEX31_YEAST	PEX31	genetic	20093466
SAC1_YEAST	SAC1	genetic	20093466
UBI4P_YEAST	UBI4	genetic	20093466
HRT3_YEAST	HRT3	physical	14747994
DLD3_YEAST	DLD3	physical	26297823
SYG_YEAST	GRS1	physical	26297823
IZH2_YEAST	IZH2	genetic	27708008
PUS9_YEAST	PUS9	genetic	27708008
RRP8_YEAST	RRP8	genetic	27708008
HRQ1_YEAST	HRQ1	genetic	27708008
PHB2_YEAST	PHB2	genetic	27708008
BRE2_YEAST	BRE2	genetic	27708008
PHO23_YEAST	PHO23	genetic	27708008
SNU66_YEAST	SNU66	genetic	27708008
CIN1_YEAST	CIN1	genetic	27708008
CTI6_YEAST	CTI6	genetic	27708008
TBCC_YEAST	CIN2	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.