GUF1_YEAST - dbPTM
GUF1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GUF1_YEAST
UniProt AC P46943
Protein Name Translation factor GUF1, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03137}
Gene Name GUF1 {ECO:0000255|HAMAP-Rule:MF_03137}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 645
Subcellular Localization Mitochondrion inner membrane
Peripheral membrane protein
Matrix side .
Protein Description Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner..
Protein Sequence MLKFRIRPVRHIRCYKRHAYFLRYNHTTTPAQKLQAQIEQIPLENYRNFSIVAHVDHGKSTLSDRLLEITHVIDPNARNKQVLDKLEVERERGITIKAQTCSMFYKDKRTGKNYLLHLIDTPGHVDFRGEVSRSYASCGGAILLVDASQGIQAQTVANFYLAFSLGLKLIPVINKIDLNFTDVKQVKDQIVNNFELPEEDIIGVSAKTGLNVEELLLPAIIDRIPPPTGRPDKPFRALLVDSWYDAYLGAVLLVNIVDGSVRKNDKVICAQTKEKYEVKDIGIMYPDRTSTGTLKTGQVGYLVLGMKDSKEAKIGDTIMHLSKVNETEVLPGFEEQKPMVFVGAFPADGIEFKAMDDDMSRLVLNDRSVTLERETSNALGQGWRLGFLGSLHASVFRERLEKEYGSKLIITQPTVPYLVEFTDGKKKLITNPDEFPDGATKRVNVAAFHEPFIEAVMTLPQEYLGSVIRLCDSNRGEQIDITYLNTNGQVMLKYYLPLSHLVDDFFGKLKSVSRGFASLDYEDAGYRISDVVKLQLLVNGNAIDALSRVLHKSEVERVGREWVKKFKEYVKSQLYEVVIQARANNKIIARETIKARRKDVLQKLHASDVSRRKKLLAKQKEGKKHMKTVGNIQINQEAYQAFLRR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
414PhosphorylationKLIITQPTVPYLVEF
EEEEECCCCCEEEEE		25.0527017623
417PhosphorylationITQPTVPYLVEFTDG
EECCCCCEEEEECCC		21.0227017623
422PhosphorylationVPYLVEFTDGKKKLI
CCEEEEECCCCEEEC		30.2727017623
607PhosphorylationVLQKLHASDVSRRKK
HHHHHHHHHHHHHHH		28.0027017623
613UbiquitinationASDVSRRKKLLAKQK
HHHHHHHHHHHHHHH		46.8117644757
614UbiquitinationSDVSRRKKLLAKQKE
HHHHHHHHHHHHHHC		47.0917644757
618UbiquitinationRRKKLLAKQKEGKKH
HHHHHHHHHHCCHHC		62.9717644757
6182-HydroxyisobutyrylationRRKKLLAKQKEGKKH
HHHHHHHHHHCCHHC		62.97-
620UbiquitinationKKLLAKQKEGKKHMK
HHHHHHHHCCHHCCE		68.6617644757
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GUF1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GUF1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GUF1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
OXA1_YEASTOXA1genetic
18442968
RM36_YEASTMRPL36genetic
19339279
CND2_YEASTBRN1genetic
27708008
KPC1_YEASTPKC1genetic
27708008
CALM_YEASTCMD1genetic
27708008
CDC10_YEASTCDC10genetic
27708008
CDC13_YEASTCDC13genetic
27708008
DAD1_YEASTDAD1genetic
27708008
CDC1_YEASTCDC1genetic
27708008
PRP3_YEASTPRP3genetic
27708008
RMRP_YEASTSNM1genetic
27708008
PRS8_YEASTRPT6genetic
27708008
PRP18_YEASTPRP18genetic
27708008
SMD1_YEASTSMD1genetic
27708008
MPPA_YEASTMAS2genetic
27708008
CDC12_YEASTCDC12genetic
27708008
MOB1_YEASTMOB1genetic
27708008
EXO70_YEASTEXO70genetic
27708008
DPB11_YEASTDPB11genetic
27708008
PRP21_YEASTPRP21genetic
27708008
HSP77_YEASTSSC1genetic
27708008
CDC11_YEASTCDC11genetic
27708008
IPL1_YEASTIPL1genetic
27708008
MED10_YEASTNUT2genetic
27708008
PRP4_YEASTPRP4genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GUF1_YEAST

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Related Literatures of Post-Translational Modification

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