DAD1_YEAST - dbPTM
DAD1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DAD1_YEAST
UniProt AC Q12248
Protein Name DASH complex subunit DAD1
Gene Name DAD1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 94
Subcellular Localization Nucleus . Cytoplasm, cytoskeleton, spindle . Chromosome, centromere, kinetochore . Associates with the mitotic spindle and the kinetochore.
Protein Description Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. The DASH ring complex may both stabilize microtubules during chromosome attachment in anaphase A, and allow the chromosome to remain attached to the depolymerizing microtubule in anaphase B. Microtubule depolymerization proceeds by protofilament splaying and induces the kinetochore-attached ring to slide longitudinally, thereby helping to transduce depolymerization energy into pulling forces to disjoin chromatids..
Protein Sequence MMASTSNDEEKLISTTDKYFIEQRNIVLQEINETMNSILNGLNGLNISLESSIAVGREFQSVSDLWKTLYDGLESLSDEAPIDEQPTLSQSKTK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
68PhosphorylationSVSDLWKTLYDGLES
CHHHHHHHHHHHHHH		20.9722369663
75PhosphorylationTLYDGLESLSDEAPI
HHHHHHHHCCCCCCC		37.9122369663
77PhosphorylationYDGLESLSDEAPIDE
HHHHHHCCCCCCCCC		42.5622369663
87PhosphorylationAPIDEQPTLSQSKTK
CCCCCCCCCCCCCCC		38.4421440633
89PhosphorylationIDEQPTLSQSKTK--
CCCCCCCCCCCCC--		34.5825752575
91PhosphorylationEQPTLSQSKTK----
CCCCCCCCCCC----		38.6328889911
93PhosphorylationPTLSQSKTK------
CCCCCCCCC------		47.4327017623
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DAD1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DAD1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DAD1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DUO1_YEASTDUO1physical
11283351
ASK1_YEASTASK1physical
12408861
DAD2_YEASTDAD2physical
12408861
DAD3_YEASTDAD3physical
12408861
DAD4_YEASTDAD4physical
12408861
DAM1_YEASTDAM1physical
12408861
DUO1_YEASTDUO1physical
12408861
SPC19_YEASTSPC19physical
12408861
SPC34_YEASTSPC34physical
12408861
ASK1_YEASTASK1physical
11782438
DAD2_YEASTDAD2physical
11782438
DUO1_YEASTDUO1physical
11782438
SPC19_YEASTSPC19physical
11782438
SPC34_YEASTSPC34physical
11782438
DAM1_YEASTDAM1physical
11553702
DUO1_YEASTDUO1physical
11553702
NDC80_YEASTNDC80physical
12925767
ASK1_YEASTASK1physical
11756468
DAD2_YEASTDAD2physical
11756468
DAM1_YEASTDAM1physical
11756468
DUO1_YEASTDUO1physical
11756468
SPC19_YEASTSPC19physical
11756468
SPC34_YEASTSPC34physical
11756468
DAD3_YEASTDAD3physical
12925767
BIM1_YEASTBIM1genetic
11553702
BUB1_YEASTBUB1genetic
11553702
BUB3_YEASTBUB3genetic
11553702
DAM1_YEASTDAM1genetic
11553702
DUO1_YEASTDUO1genetic
11553702
STU1_YEASTSTU1genetic
11553702
SPC19_YEASTSPC19physical
16554755
DUO1_YEASTDUO1physical
16554755
SPC34_YEASTSPC34physical
16554755
AHC2_YEASTAHC2physical
17634282
MED3_YEASTPGD1physical
17634282
DUO1_YEASTDUO1physical
17634282
YL031_YEASTYLR031Wphysical
17634282
CLF1_YEASTCLF1physical
17634282
YM46_YEASTYMR181Cphysical
17634282
ASK1_YEASTASK1physical
15640796
DAM1_YEASTDAM1physical
15640796
SPC34_YEASTSPC34physical
15640796
DUO1_YEASTDUO1physical
15640796
SPC19_YEASTSPC19physical
15640796
DAD2_YEASTDAD2physical
15640796
DAD3_YEASTDAD3physical
15640796
DAD4_YEASTDAD4physical
15640796
HSK3_YEASTHSK3physical
15640796
DAD3_YEASTDAD3physical
17460120
DAD1_YEASTDAD1physical
19065263
DUO1_YEASTDUO1physical
20730753
DAM1_YEASTDAM1physical
20730753
SPC34_YEASTSPC34physical
20730753
STU1_YEASTSTU1genetic
27708008
TIM22_YEASTTIM22genetic
27708008
RPB7_YEASTRPB7genetic
27708008
RSP5_YEASTRSP5genetic
27708008
PP12_YEASTGLC7genetic
27708008
MOB2_YEASTMOB2genetic
27708008
DUO1_YEASTDUO1genetic
27708008
SP105_YEASTSPC105genetic
27708008
DAM1_YEASTDAM1genetic
27708008
SPC24_YEASTSPC24genetic
27708008
HRP1_YEASTHRP1genetic
27708008
ARP7_YEASTARP7genetic
27708008
DCC1_YEASTDCC1genetic
27708008
MAD1_YEASTMAD1genetic
27708008
CTF8_YEASTCTF8genetic
27708008
MAD2_YEASTMAD2genetic
27708008
CTK1_YEASTCTK1genetic
27708008
RL22A_YEASTRPL22Agenetic
27708008
ALAM_YEASTALT1genetic
27708008
CTF18_YEASTCTF18genetic
27708008
BUD21_YEASTBUD21genetic
27708008
KAR3_YEASTKAR3genetic
27708008
ASK1_YEASTASK1genetic
29674565
STU1_YEASTSTU1genetic
29674565
DCC1_YEASTDCC1genetic
29674565
KRE28_YEASTKRE28genetic
29674565
MAD1_YEASTMAD1genetic
29674565
MMS2_YEASTMMS2genetic
29674565
DAM1_YEASTDAM1genetic
29674565
CTF8_YEASTCTF8genetic
29674565
DSN1_YEASTDSN1genetic
29674565
MAD2_YEASTMAD2genetic
29674565
SMC3_YEASTSMC3genetic
29674565
YJ9I_YEASTYJR141Wgenetic
29674565
PRS7_YEASTRPT1genetic
29674565
TAD3_YEASTTAD3genetic
29674565
PDS5_YEASTPDS5genetic
29674565
CTF18_YEASTCTF18genetic
29674565
BUB3_YEASTBUB3genetic
29674565
NEW1_YEASTNEW1genetic
29674565
YAR1_YEASTYAR1genetic
29674565
KAR3_YEASTKAR3genetic
29674565
TTL_YEASTPBY1genetic
29674565
YMW4_YEASTYMR074Cgenetic
29674565
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DAD1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-87; SER-89 AND SER-91,AND MASS SPECTROMETRY.

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