DLD3_YEAST - dbPTM
DLD3_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DLD3_YEAST
UniProt AC P39976
Protein Name D-2-hydroxyglutarate--pyruvate transhydrogenase DLD3 {ECO:0000305}
Gene Name DLD3
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 496
Subcellular Localization Cytoplasm .
Protein Description Catalyzes the reversible oxidation of (R)-2-hydroxyglutarate to 2-oxoglutarate coupled to reduction of pyruvate to (R)-lactate. Can also use oxaloacetate as electron acceptor instead of pyruvate producing (R)-malate..
Protein Sequence MTAAHPVAQLTAEAYPKVKRNPNFKVLDSEDLAYFRSILSNDEILNSQAPEELASFNQDWMKKYRGQSNLILLPNSTDKVSKIMKYCNDKKLAVVPQGGNTDLVGASVPVFDEIVLSLRNMNKVRDFDPVSGTFKCDAGVVMRDAHQFLHDHDHIFPLDLPSRNNCQVGGVVSTNAGGLNFLRYGSLHGNVLGLEVVLPNGEIISNINALRKDNTGYDLKQLFIGAEGTIGVVTGVSIVAAAKPKALNAVFFGIENFDTVQKLFVKAKSELSEILSAFEFMDRGSIECTIEYLKDLPFPLENQHNFYVLIETSGSNKRHDDEKLTAFLKDTTDSKLISEGMMAKDKADFDRLWTWRKSVPTACNSYGGMYKYDMSLQLKDLYSVSAAVTERLNAAGLIGDAPKPVVKSCGYGHVGDGNIHLNIAVREFTKQIEDLLEPFVYEYIASKKGSISAEHGIGFHKKGKLHYTRSDIEIRFMKDIKNHYDPNGILNPYKYI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
11PhosphorylationAHPVAQLTAEAYPKV
CCHHHHHHHHHCCHH		15.4630377154
15PhosphorylationAQLTAEAYPKVKRNP
HHHHHHHCCHHCCCC		8.6230377154
17UbiquitinationLTAEAYPKVKRNPNF
HHHHHCCHHCCCCCC		47.9512872131
25UbiquitinationVKRNPNFKVLDSEDL
HCCCCCCCCCCHHHH		48.8317644757
29PhosphorylationPNFKVLDSEDLAYFR
CCCCCCCHHHHHHHH		28.9322369663
34PhosphorylationLDSEDLAYFRSILSN
CCHHHHHHHHHHHCC		13.5622369663
55PhosphorylationQAPEELASFNQDWMK
CCHHHHHHCCHHHHH		37.0430377154
62AcetylationSFNQDWMKKYRGQSN
HCCHHHHHHHCCCCC		42.2624489116
63UbiquitinationFNQDWMKKYRGQSNL
CCHHHHHHHCCCCCE		24.8717644757
64PhosphorylationNQDWMKKYRGQSNLI
CHHHHHHHCCCCCEE		17.9219795423
68PhosphorylationMKKYRGQSNLILLPN
HHHHCCCCCEEECCC		36.1122369663
76PhosphorylationNLILLPNSTDKVSKI
CEEECCCCHHHHHHH		35.7222369663
77PhosphorylationLILLPNSTDKVSKIM
EEECCCCHHHHHHHH		46.6222369663
79UbiquitinationLLPNSTDKVSKIMKY
ECCCCHHHHHHHHHH		48.7917644757
85AcetylationDKVSKIMKYCNDKKL
HHHHHHHHHCCCCCE		50.5625381059
90UbiquitinationIMKYCNDKKLAVVPQ
HHHHCCCCCEEEECC		35.3817644757
91UbiquitinationMKYCNDKKLAVVPQG
HHHCCCCCEEEECCC		44.5417644757
107PhosphorylationNTDLVGASVPVFDEI
CCCCCCCCCCCHHHH		22.4825005228
117PhosphorylationVFDEIVLSLRNMNKV
CHHHHHHHHCCCCCC		17.8725005228
123UbiquitinationLSLRNMNKVRDFDPV
HHHCCCCCCCCCCCC		28.0717644757
135UbiquitinationDPVSGTFKCDAGVVM
CCCCCEEEECCEEEE		30.9224961812
212UbiquitinationSNINALRKDNTGYDL
ECHHHHCCCCCCCCH		57.0617644757
215PhosphorylationNALRKDNTGYDLKQL
HHHCCCCCCCCHHHH		47.4527214570
245UbiquitinationIVAAAKPKALNAVFF
HHHCCCCHHHHEEEE		65.8717644757
262UbiquitinationENFDTVQKLFVKAKS
CCHHHHHHHHHHHHH		39.2917644757
323AcetylationNKRHDDEKLTAFLKD
CCCCCHHHHHHHHHH		59.1224489116
323UbiquitinationNKRHDDEKLTAFLKD
CCCCCHHHHHHHHHH		59.1217644757
329UbiquitinationEKLTAFLKDTTDSKL
HHHHHHHHHCCCHHH		46.7217644757
329AcetylationEKLTAFLKDTTDSKL
HHHHHHHHHCCCHHH		46.7224489116
329SuccinylationEKLTAFLKDTTDSKL
HHHHHHHHHCCCHHH		46.7223954790
335UbiquitinationLKDTTDSKLISEGMM
HHHCCCHHHHHCCCC		53.2924961812
335AcetylationLKDTTDSKLISEGMM
HHHCCCHHHHHCCCC		53.2922865919
344AcetylationISEGMMAKDKADFDR
HHCCCCCCCHHHHHH		41.6925381059
357UbiquitinationDRLWTWRKSVPTACN
HHHHHHHHCCCCHHH		47.5723749301
358PhosphorylationRLWTWRKSVPTACNS
HHHHHHHCCCCHHHH		25.4219779198
372PhosphorylationSYGGMYKYDMSLQLK
HCCCEEEEEEEEEHH		10.2125533186
403UbiquitinationGLIGDAPKPVVKSCG
CCCCCCCCCCEEECC		52.7624961812
407UbiquitinationDAPKPVVKSCGYGHV
CCCCCCEEECCCCCC		40.0217644757
408PhosphorylationAPKPVVKSCGYGHVG
CCCCCEEECCCCCCC		10.9328889911
411PhosphorylationPVVKSCGYGHVGDGN
CCEEECCCCCCCCCC		14.3725533186
430UbiquitinationIAVREFTKQIEDLLE
EEHHHHHHHHHHHHH		55.3817644757
447UbiquitinationVYEYIASKKGSISAE
HHHHHHHCCCCCEEE		52.7317644757
448UbiquitinationYEYIASKKGSISAEH
HHHHHHCCCCCEEEC		56.2317644757
450PhosphorylationYIASKKGSISAEHGI
HHHHCCCCCEEECCC		23.4224961812
452PhosphorylationASKKGSISAEHGIGF
HHCCCCCEEECCCEE		29.3324961812
461UbiquitinationEHGIGFHKKGKLHYT
ECCCEEEECCCEEEE		62.0417644757
461AcetylationEHGIGFHKKGKLHYT
ECCCEEEECCCEEEE		62.0422865919
462UbiquitinationHGIGFHKKGKLHYTR
CCCEEEECCCEEEEC		53.3517644757
467PhosphorylationHKKGKLHYTRSDIEI
EECCCEEEECHHHEE		17.8122369663
468PhosphorylationKKGKLHYTRSDIEIR
ECCCEEEECHHHEEE		16.9822369663
470PhosphorylationGKLHYTRSDIEIRFM
CCEEEECHHHEEEEE		34.8322369663
481AcetylationIRFMKDIKNHYDPNG
EEEEHHHHHCCCCCC		48.0522865919
481UbiquitinationIRFMKDIKNHYDPNG
EEEEHHHHHCCCCCC		48.0524961812
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DLD3_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DLD3_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DLD3_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
LSP1_YEASTLSP1physical
18467557
HSP71_YEASTSSA1physical
19536198
SSB1_YEASTSSB1physical
19536198
HRT3_YEASTHRT3physical
26297823
PRP9_YEASTPRP9genetic
27708008
KTHY_YEASTCDC8genetic
27708008
PSA7_YEASTPRE10genetic
27708008
RLA1_YEASTRPP1Agenetic
27708008
GCS1_YEASTGCS1genetic
27708008
SNF6_YEASTSNF6genetic
27708008
FLX1_YEASTFLX1genetic
27708008
MDM35_YEASTMDM35genetic
27708008
ERG3_YEASTERG3genetic
27708008
EIF3J_YEASTHCR1genetic
27708008
UPS1_YEASTUPS1genetic
27708008
PUS7_YEASTPUS7genetic
27708008
VPH1_YEASTVPH1genetic
27708008
MSC6_YEASTMSC6genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
YME1_YEASTYME1genetic
27708008
MD1L1_HUMANMAD1L1physical
27107014
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DLD3_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-470, AND MASSSPECTROMETRY.
Ubiquitylation
ReferencePubMed
"A proteomics approach to understanding protein ubiquitination.";
Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D.,Marsischky G., Roelofs J., Finley D., Gygi S.P.;
Nat. Biotechnol. 21:921-926(2003).
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-17, AND MASSSPECTROMETRY.

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