ERC1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ERC1_YEAST
• UniProt AC: P38767
• Protein Name: Ethionine resistance-conferring protein 1
• Gene Name: ERC1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 581
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: Probable transporter involved in ethionine resistance. Overproduction leads to accumulation of S-adenosylmethionine..
• Protein Sequence: MSKQFSHTTNDRRSSIIYSTSVGKAGLFTPADYIPQESEENLIEGEEQEGSEEEPSYTGNDDETEREGEYHSLLDANNSRTLQQEAWQQGYDSHDRKRLLDEERDLLIDNKLLSQHGNGGGDIESHGHGQAIGPDEEERPAEIANTWESAIESGQKISTTFKRETQVITMNALPLIFTFILQNSLSLASIFSVSHLGTKELGGVTLGSMTANITGLAAIQGLCTCLDTLCAQAYGAKNYHLVGVLVQRCAVITILAFLPMMYVWFVWSEKILALMIPERELCALAANYLRVTAFGVPGFILFECGKRFLQCQGIFHASTIVLFVCAPLNALMNYLLVWNDKIGIGYLGAPLSVVINYWLMTLGLLIYAMTTKHKERPLKCWNGIIPKEQAFKNWRKMINLAIPGVVMVEAEFLGFEVLTIFASHLGTDALGAQSIVATIASLAYQVPFSISVSTSTRVANFIGASLYDSCMITCRVSLLLSFVCSSMNMFVICRYKEQIASLFSTESAVVKMVVDTLPLLAFMQLFDAFNASTAGCLRGQGRQKNRWVHQPSRILLPRCAHGICVSIPVSSGCRRLMVGYN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	TTNDRRSSIIYSTSV CCCCCCCCEEEECCC	15.93	28889911
97	Ubiquitination	GYDSHDRKRLLDEER CCCCHHHHHHHHHHH	54.15	17644757
111	Ubiquitination	RDLLIDNKLLSQHGN HHHHHCHHHHHHCCC	47.24	17644757

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ERC1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ERC1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ERC1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
METK1_YEAST	SAM1	genetic	27698120
METK2_YEAST	SAM2	genetic	27698120
SNF1_YEAST	SNF1	genetic	27698120
ERF3_YEAST	SUP35	genetic	27708008
SEC22_YEAST	SEC22	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.