TR112_YEAST - dbPTM
TR112_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TR112_YEAST
UniProt AC P53738
Protein Name Multifunctional methyltransferase subunit TRM112
Gene Name TRM112
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 135
Subcellular Localization Cytoplasm . Nucleus .
Protein Description Acts as an activator of both rRNA/tRNA and protein methyltransferases. Together with methyltransferase MTQ2, required for the methylation of eRF1 on 'Gln-182'. Together with methyltransferase TRM11, required for the formation of 2-methylguanosine at position 10 (m2G10) in tRNA. Together with methyltransferase BUD23, required for the formation of 7-methylguanine at position 1575 (m7G1575) in 18S rRNA. Involved in biogenesis of both 40S and 60S ribosomal subunits..
Protein Sequence MKFLTTNFLKCSVKACDTSNDNFPLQYDGSKCQLVQDESIEFNPEFLLNIVDRVDWPAVLTVAAELGNNALPPTKPSFPSSIQELTDDDMAILNDLHTLLLQTSIAEGEMKCRNCGHIYYIKNGIPNLLLPPHLV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Ubiquitination------MKFLTTNFL
------CCCCHHHCE		49.4323749301
10AcetylationFLTTNFLKCSVKACD
CCHHHCEEEEEEECC		21.9624489116
18PhosphorylationCSVKACDTSNDNFPL
EEEEECCCCCCCCCC		29.3428132839
19PhosphorylationSVKACDTSNDNFPLQ
EEEECCCCCCCCCCE		29.0028132839
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TR112_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TR112_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TR112_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
LYS9_YEASTLYS9physical
11805826
TRM9_YEASTTRM9physical
11805826
TRM11_YEASTTRM11physical
11805826
TRM9_YEASTTRM9physical
16554755
TRM11_YEASTTRM11physical
16554755
LYS9_YEASTLYS9physical
16429126
MTQ2_YEASTMTQ2physical
16429126
TRM11_YEASTTRM11physical
16429126
MTQ2_YEASTMTQ2physical
11283351
MTQ2_YEASTMTQ2physical
18719252
SFH1_YEASTSFH1physical
18719252
TRM9_YEASTTRM9physical
18657261
LYS9_YEASTLYS9physical
20400505
TRM9_YEASTTRM9physical
20400505
MTQ2_YEASTMTQ2physical
20400505
TRM11_YEASTTRM11physical
20400505
MTQ2_YEASTMTQ2physical
22493060
TRM9_YEASTTRM9physical
22493060
TRM11_YEASTTRM11physical
22493060
BUD23_YEASTBUD23physical
22493060
RPA1_YEASTRPA190physical
22493060
RPA2_YEASTRPA135physical
22493060
SPT5_YEASTSPT5physical
22493060
IF2P_YEASTFUN12physical
22493060
EIF3B_YEASTPRT1physical
22493060
ERF1_YEASTSUP45physical
22493060
EIF3I_YEASTTIF34physical
22493060
SSBP1_YEASTSBP1physical
22493060
NACB1_YEASTEGD1physical
22493060
NACA_YEASTEGD2physical
22493060
TRM1_YEASTTRM1physical
22493060
TR112_YEASTTRM112physical
22493060
FBRL_YEASTNOP1physical
22493060
RRP5_YEASTRRP5physical
22493060
DHR1_YEASTECM16physical
22493060
RRP12_YEASTRRP12physical
22493060
NAT10_YEASTKRE33physical
22493060
UTP14_YEASTUTP14physical
22493060
TSR1_YEASTTSR1physical
22493060
ARB1_YEASTARB1physical
22493060
CBF5_YEASTCBF5physical
22493060
RUVB2_YEASTRVB2physical
22493060
RS5_YEASTRPS5physical
22493060
RS7B_YEASTRPS7Bphysical
22493060
RS17A_YEASTRPS17Aphysical
22493060
RS11A_YEASTRPS11Aphysical
22493060
RS11B_YEASTRPS11Aphysical
22493060
RL3_YEASTRPL3physical
22493060
RL5_YEASTRPL5physical
22493060
RL25_YEASTRPL25physical
22493060
RL23A_YEASTRPL23Aphysical
22493060
RL23B_YEASTRPL23Aphysical
22493060
RLA2_YEASTRPP2Aphysical
22493060
MDN1_YEASTMDN1physical
22493060
IMB4_YEASTKAP123physical
22493060
ERB1_YEASTERB1physical
22493060
NOC3_YEASTNOC3physical
22493060
NOG1_YEASTNOG1physical
22493060
NOP2_YEASTNOP2physical
22493060
PESC_YEASTNOP7physical
22493060
DBP2_YEASTDBP2physical
22493060
DBP3_YEASTDBP3physical
22493060
HAS1_YEASTHAS1physical
22493060
BUD23_YEASTBUD23physical
22956767
UTP14_YEASTUTP14genetic
22956767
RL10_YEASTRPL10physical
22956767
NOP2_YEASTNOP2physical
22956767
RCM1_YEASTRCM1physical
22956767
RL8A_YEASTRPL8Aphysical
22956767
BUD23_YEASTBUD23physical
24710271
BUD23_YEASTBUD23physical
25489090
MED6_YEASTMED6genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TR112_YEAST

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Related Literatures of Post-Translational Modification

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