| UniProt ID | TSR1_YEAST | |
|---|---|---|
| UniProt AC | Q07381 | |
| Protein Name | Ribosome biogenesis protein TSR1 | |
| Gene Name | TSR1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 788 | |
| Subcellular Localization | Cytoplasm. Nucleus, nucleolus. | |
| Protein Description | Required for 40S ribosomal subunit synthesis. Required for normal export of the pre-40S particles from the nucleus to the cytoplasm. Its subcellular location and association with pre-40S subunitshifts from mixed cytoplasm/nucleus to all nuclear in RPS19 disruptions, suggesting it acts after the ribosomal protein.. | |
| Protein Sequence | MAGHSHRSSLKNGHKSYKSKHASKGALKRLYKGKVEKEPVGTGKPDKQVSKLQRKNKAKQLRAQRILDSIENRKLFEGKNGAAKIITIVPLVNDLDPLDILYKLLKCADDEGIMVQEVDSKRIFNVHIKKFKSNLKIIIPDMTNFLNILDCAKVADFVVFGLSGVQEVDEEFGEQIIRALELQGIASYIGVISNLSAVHEKEKFQLDVKQSLESYFKHFFPSEERVYNLEKNSDALNVLRTLCQRLPRSINWRDNRGYVVADFVDFVETSPDSGDLVIEGTVRGIGFNANRLVHIPDFGDFQLNKIEKISESSQKRKIIKEKATDSLSLELDLQTVFESNMNRDTLDEYAPEGTEDWSDYDEDFEYDGLTTARYDDHGFLPGREQTSKKAAVPKGTSDYQAKWYLDDVIDANEEEEAEQTNGKDETMMEIDDEMMVEQDNEEVAGDEEYDIEDNEGFEELSPEEEERQLREFRDMEKEDREFPDEIELEPSESAIERLKRYRGLKNLYNCDWQVDEKDPSSPAEWKRLLRIGNYKNTKNRIIKETKNEAQAIAGDRIRMFIRFPKFLLEKIQDPKQLLFAVYGLLLHEHKNAVVNFSLQRWEQYDKPVPSQEPIVVQYGVRRYTIQPLFSQGSNSPNNVHKYERFLHPDTVSVATCIAPVDFTQSPAIFFKPSPTDAKNIELIGHGTFLNADHSRILAKRAILTGHPFRFHKTVVTVRYMFFRPEDVEWFKSIPLFTKSGRSGFIKESLGTHGYFKATFDGKLSAQDVVAMSLYKRMWPMPSLPWNGM | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 15 | Acetylation | SSLKNGHKSYKSKHA HCCCCCCCCHHHHHC | 57.80 | 25381059 | |
| 18 | Acetylation | KNGHKSYKSKHASKG CCCCCCHHHHHCCHH | 61.18 | 25381059 | |
| 20 | Acetylation | GHKSYKSKHASKGAL CCCCHHHHHCCHHHH | 38.75 | 25381059 | |
| 24 | Acetylation | YKSKHASKGALKRLY HHHHHCCHHHHHHHH | 49.32 | 25381059 | |
| 28 | Acetylation | HASKGALKRLYKGKV HCCHHHHHHHHCCCC | 39.56 | 25381059 | |
| 51 | Acetylation | KPDKQVSKLQRKNKA CCHHHHHHHHHHHHH | 50.19 | 25381059 | |
| 69 | Phosphorylation | RAQRILDSIENRKLF HHHHHHHHHHHHHHC | 28.49 | 30377154 | |
| 84 | Ubiquitination | EGKNGAAKIITIVPL CCCCCCEEEEEEEEC | 33.82 | 17644757 | |
| 103 | Ubiquitination | DPLDILYKLLKCADD CHHHHHHHHHHHCCC | 43.85 | 17644757 | |
| 136 | Ubiquitination | KKFKSNLKIIIPDMT HHHHHCCEEEECCCC | 35.79 | 15699485 | |
| 153 | Ubiquitination | LNILDCAKVADFVVF HHHHHHHHHCCEEEE | 44.26 | 15699485 | |
| 196 | Phosphorylation | IGVISNLSAVHEKEK HHHHHCCHHHHCHHH | 32.28 | 27214570 | |
| 231 | Acetylation | ERVYNLEKNSDALNV HHEEECCCCHHHHHH | 65.99 | 24489116 | |
| 233 | Phosphorylation | VYNLEKNSDALNVLR EEECCCCHHHHHHHH | 35.02 | 27017623 | |
| 305 | Ubiquitination | FGDFQLNKIEKISES CCCCCHHHHHHCCHH | 61.92 | 17644757 | |
| 308 | Ubiquitination | FQLNKIEKISESSQK CCHHHHHHCCHHHHH | 55.81 | 17644757 | |
| 354 | Phosphorylation | DEYAPEGTEDWSDYD HHHCCCCCCCCCCCC | 29.16 | 19795423 | |
| 358 | Phosphorylation | PEGTEDWSDYDEDFE CCCCCCCCCCCCCCC | 38.32 | 19795423 | |
| 360 | Phosphorylation | GTEDWSDYDEDFEYD CCCCCCCCCCCCCCC | 18.73 | 19795423 | |
| 366 | Phosphorylation | DYDEDFEYDGLTTAR CCCCCCCCCCCEEEE | 18.46 | 19779198 | |
| 505 | Ubiquitination | LKRYRGLKNLYNCDW HHHHCCCHHHHCCCC | 47.97 | 15699485 | |
| 517 | Ubiquitination | CDWQVDEKDPSSPAE CCCCCCCCCCCCHHH | 71.16 | 15699485 | |
| 520 | Phosphorylation | QVDEKDPSSPAEWKR CCCCCCCCCHHHHHH | 60.12 | 27717283 | |
| 521 | Phosphorylation | VDEKDPSSPAEWKRL CCCCCCCCHHHHHHH | 33.25 | 27717283 | |
| 526 | Ubiquitination | PSSPAEWKRLLRIGN CCCHHHHHHHHHHCC | 25.36 | 15699485 | |
| 565 | Ubiquitination | RMFIRFPKFLLEKIQ HHHHHCHHHHHHHCC | 46.03 | 17644757 | |
| 570 | Ubiquitination | FPKFLLEKIQDPKQL CHHHHHHHCCCHHHH | 45.71 | 17644757 | |
| 633 | Phosphorylation | QPLFSQGSNSPNNVH CCCCCCCCCCCCCCC | 26.88 | 23749301 | |
| 641 | Acetylation | NSPNNVHKYERFLHP CCCCCCCCCHHHCCC | 44.52 | 24489116 | |
| 641 | Ubiquitination | NSPNNVHKYERFLHP CCCCCCCCCHHHCCC | 44.52 | 15699485 | |
| 671 | Ubiquitination | QSPAIFFKPSPTDAK CCCEEEECCCCCCCC | 33.56 | 17644757 | |
| 678 | Ubiquitination | KPSPTDAKNIELIGH CCCCCCCCCEEEEEC | 62.36 | 17644757 | |
| 746 | Acetylation | SGRSGFIKESLGTHG CCCCCCCCCHHCCCC | 38.70 | 24489116 | |
| 772 | Phosphorylation | AQDVVAMSLYKRMWP HHHHHHHHHHHHHCC | 20.86 | 28889911 | |
| 775 | Acetylation | VVAMSLYKRMWPMPS HHHHHHHHHHCCCCC | 40.86 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TSR1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TSR1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TSR1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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