| UniProt ID | NUG1_YEAST | |
|---|---|---|
| UniProt AC | P40010 | |
| Protein Name | Nuclear GTP-binding protein NUG1 | |
| Gene Name | NUG1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 520 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | GTPase required for 60S ribosomal subunit export to the cytoplasm.. | |
| Protein Sequence | MRVRKRQSRRTSTKLKEGIKKKASAHRKKEKKMAKKDVTWRSRSKKDPGIPSNFPYKAKILEEIEAKKMKDLEERELAKQQRLEARKAAKEQGVDAMDEDMIEDDENGLAALVESAQQAAAEYEGTPSNDADVRDDELDVIDYNIDFYGEDVEGESELEKSRKAYDKIFKSVIDASDVILYVLDARDPESTRSRKVEEAVLQSQGKRLILILNKVDLIPPHVLEQWLNYLKSSFPTIPLRASSGAVNGTSFNRKLSQTTTASALLESLKTYSNNSNLKRSIVVGVIGYPNVGKSSVINALLARRGGQSKACPVGNEAGVTTSLREIKIDNKLKILDSPGICFPSENKKRSKVEHEAELALLNALPAKHIVDPYPAVLMLVKRLAKSDEMTESFKKLYEIPPIPANDADTFTKHFLIHVARKRGRLGKGGIPNLASAGLSVLNDWRDGKILGWVLPNTSAAASQQDKQNLSTINTGTKQAPIAANESTIVSEWSKEFDLDGLFSSLDKAIDASKDQDTMME | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 11 | Phosphorylation | RKRQSRRTSTKLKEG CHHHHHHHHHHHHHH | 39.37 | 28889911 | |
| 14 | Acetylation | QSRRTSTKLKEGIKK HHHHHHHHHHHHHHH | 58.28 | 25381059 | |
| 16 | Acetylation | RRTSTKLKEGIKKKA HHHHHHHHHHHHHHH | 56.29 | 25381059 | |
| 20 | Acetylation | TKLKEGIKKKASAHR HHHHHHHHHHHHHHH | 60.11 | 25381059 | |
| 59 | Acetylation | SNFPYKAKILEEIEA CCCCHHHHHHHHHHH | 43.61 | 25381059 | |
| 126 | Phosphorylation | AAAEYEGTPSNDADV HHHHHCCCCCCCCCC | 16.17 | 27214570 | |
| 128 | Phosphorylation | AEYEGTPSNDADVRD HHHCCCCCCCCCCCC | 47.37 | 28889911 | |
| 195 | Ubiquitination | PESTRSRKVEEAVLQ CCCHHCHHHHHHHHH | 56.07 | 17644757 | |
| 206 | Ubiquitination | AVLQSQGKRLILILN HHHHCCCCEEEEEEE | 36.07 | 17644757 | |
| 249 | Phosphorylation | SSGAVNGTSFNRKLS CCCCCCCCCCCCHHC | 25.58 | 30377154 | |
| 250 | Phosphorylation | SGAVNGTSFNRKLSQ CCCCCCCCCCCHHCC | 23.17 | 25752575 | |
| 254 | Ubiquitination | NGTSFNRKLSQTTTA CCCCCCCHHCCCCCH | 54.30 | 17644757 | |
| 256 | Phosphorylation | TSFNRKLSQTTTASA CCCCCHHCCCCCHHH | 28.63 | 28889911 | |
| 259 | Phosphorylation | NRKLSQTTTASALLE CCHHCCCCCHHHHHH | 16.84 | 30377154 | |
| 269 | Ubiquitination | SALLESLKTYSNNSN HHHHHHHHHHCCCCC | 55.48 | 17644757 | |
| 293 | Ubiquitination | IGYPNVGKSSVINAL ECCCCCCHHHHHHHH | 34.96 | 17644757 | |
| 309 | Ubiquitination | ARRGGQSKACPVGNE HHCCCCCCCCCCCCC | 46.23 | 15699485 | |
| 320 | Phosphorylation | VGNEAGVTTSLREIK CCCCCCCCCEEEEEE | 15.11 | 30377154 | |
| 321 | Phosphorylation | GNEAGVTTSLREIKI CCCCCCCCEEEEEEE | 24.29 | 28889911 | |
| 322 | Phosphorylation | NEAGVTTSLREIKID CCCCCCCEEEEEEEC | 18.96 | 30377154 | |
| 333 | Ubiquitination | IKIDNKLKILDSPGI EEECCCCEECCCCCC | 42.72 | 17644757 | |
| 337 | Phosphorylation | NKLKILDSPGICFPS CCCEECCCCCCCCCC | 22.91 | 28889911 | |
| 347 | Ubiquitination | ICFPSENKKRSKVEH CCCCCCCCCCCCCCH | 45.58 | 17644757 | |
| 348 | Ubiquitination | CFPSENKKRSKVEHE CCCCCCCCCCCCCHH | 73.76 | 17644757 | |
| 351 | Acetylation | SENKKRSKVEHEAEL CCCCCCCCCCHHHHH | 56.53 | 24489116 | |
| 381 | Acetylation | PAVLMLVKRLAKSDE HHHHHHHHHHHCCHH | 37.42 | 24489116 | |
| 392 | Phosphorylation | KSDEMTESFKKLYEI CCHHHHHHHHHHHCC | 32.95 | 30377154 | |
| 394 | Ubiquitination | DEMTESFKKLYEIPP HHHHHHHHHHHCCCC | 51.66 | 23749301 | |
| 427 | Ubiquitination | RKRGRLGKGGIPNLA HHCCCCCCCCCCCHH | 59.56 | 17644757 | |
| 448 | Ubiquitination | LNDWRDGKILGWVLP HCCCCCCCEEEEECC | 38.76 | 17644757 | |
| 457 | Phosphorylation | LGWVLPNTSAAASQQ EEEECCCCHHHHHHH | 20.15 | 23749301 | |
| 462 | Phosphorylation | PNTSAAASQQDKQNL CCCHHHHHHHHHHHH | 24.53 | 25752575 | |
| 470 | Phosphorylation | QQDKQNLSTINTGTK HHHHHHHHCCCCCCC | 34.49 | 30377154 | |
| 471 | Phosphorylation | QDKQNLSTINTGTKQ HHHHHHHCCCCCCCC | 22.78 | 30377154 | |
| 474 | Phosphorylation | QNLSTINTGTKQAPI HHHHCCCCCCCCCCC | 42.23 | 21440633 | |
| 486 | Phosphorylation | APIAANESTIVSEWS CCCCCCCCCHHEEHH | 24.20 | 27017623 | |
| 487 | Phosphorylation | PIAANESTIVSEWSK CCCCCCCCHHEEHHH | 21.15 | 27017623 | |
| 503 | Phosphorylation | FDLDGLFSSLDKAID CCCHHHHHHHHHHHH | 34.73 | 30377154 | |
| 504 | Phosphorylation | DLDGLFSSLDKAIDA CCHHHHHHHHHHHHH | 33.00 | 21440633 | |
| 512 | Phosphorylation | LDKAIDASKDQDTMM HHHHHHHCCCCCCCC | 32.77 | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NUG1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NUG1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NUG1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-128; THR-321 ANDSER-462, AND MASS SPECTROMETRY. | |
