| UniProt ID | NOP53_YEAST | |
|---|---|---|
| UniProt AC | Q12080 | |
| Protein Name | Ribosome biogenesis protein NOP53 {ECO:0000305} | |
| Gene Name | NOP53 {ECO:0000312|SGD:S000006067} | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 455 | |
| Subcellular Localization | Nucleus, nucleolus . Nucleus, nucleoplasm . Does not shuttle from the nucleus to the cytoplasm (PubMed:16043506). | |
| Protein Description | Late-acting factor in the nuclear maturation of 60S ribosomal subunits, which is required for normal acquisition of export competence. Required for the export of the large subunit. Acts to stimulate the RNase activity of the exosome complex, and may recruit the exosome to 7S pre-rRNA for processing. Associates with numerous RNAs including the 27S and 7S pre-rRNAs and the box H/ACA snoRNA snR37. Also interacts (via N-terminal region) with the mature 25S rRNA and the mature 5.8S rRNA.. | |
| Protein Sequence | MAPTNLTKKPSQYKQSSRKGKKAWRKNIDLSDVEQYMEKKIDHEITHGTSDITSLQNDALFHVDVEGDEILKNKLIKRKQIKKVLKSKEILDAVKTNSKIAALNHHKNSSGNPNKIQGVSKHELKKLMALAGRVHGESKIKNRVAKDGLVKTTAGDLWGEESNSKKQKVKLPSGIKLDVEKKDQIPEELLKKSTTSWSTASVRPSTLDIEPIAVKEFTEIPHAGKSYNPNNKAWSELINKEYKEEKAREDERIALEKYKERIRHLMETLDDNEEEESSSNEEEEEEEEENENENESTQCSGSDKEIKLSINKPVKNKKKTKYQRNKAKRHEEKVKLQQELKELRQRVKDLEEVINSEETEILSAIESDSNKVKKSKKNKKHKLGTKYSVIDERLEIKFSDELSDSLRKLKPEGNLLYDTVRKLQSSGKVETRVPVRKGRKYKQKITEKWTHKDFK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 4 | Phosphorylation | ----MAPTNLTKKPS ----CCCCCCCCCHH | 33.07 | 19823750 | |
| 7 | Phosphorylation | -MAPTNLTKKPSQYK -CCCCCCCCCHHHHH | 38.81 | 19823750 | |
| 14 | Acetylation | TKKPSQYKQSSRKGK CCCHHHHHHCCHHHH | 35.75 | 25381059 | |
| 26 | Acetylation | KGKKAWRKNIDLSDV HHHHHHHHCCCHHHH | 47.78 | 22865919 | |
| 31 | Phosphorylation | WRKNIDLSDVEQYME HHHCCCHHHHHHHHH | 35.54 | 22369663 | |
| 39 | Acetylation | DVEQYMEKKIDHEIT HHHHHHHHHCCCCCC | 38.20 | 24489116 | |
| 95 | Acetylation | KEILDAVKTNSKIAA HHHHHHHHHCHHHHH | 43.65 | 25381059 | |
| 99 | Acetylation | DAVKTNSKIAALNHH HHHHHCHHHHHHHCC | 38.13 | 25381059 | |
| 121 | Acetylation | NKIQGVSKHELKKLM CCCCCCCHHHHHHHH | 38.40 | 24489116 | |
| 146 | Acetylation | KIKNRVAKDGLVKTT HHCCHHHCCCCEECC | 49.85 | 25381059 | |
| 162 | Phosphorylation | GDLWGEESNSKKQKV HHCCCCCCCCCCCEE | 41.94 | 21440633 | |
| 164 | Phosphorylation | LWGEESNSKKQKVKL CCCCCCCCCCCEEEC | 50.97 | 21440633 | |
| 173 | Phosphorylation | KQKVKLPSGIKLDVE CCEEECCCCCCCCHH | 64.68 | 19795423 | |
| 195 | Phosphorylation | ELLKKSTTSWSTASV HHHHHCCCCCCCCCC | 34.98 | 30377154 | |
| 196 | Phosphorylation | LLKKSTTSWSTASVR HHHHCCCCCCCCCCC | 21.08 | 30377154 | |
| 225 | Acetylation | TEIPHAGKSYNPNNK CCCCCCCCCCCCCCH | 51.02 | 24489116 | |
| 356 | Phosphorylation | DLEEVINSEETEILS HHHHHHCCHHHHHHH | 26.19 | 21440633 | |
| 359 | Phosphorylation | EVINSEETEILSAIE HHHCCHHHHHHHHHH | 25.03 | 28889911 | |
| 363 | Phosphorylation | SEETEILSAIESDSN CHHHHHHHHHHCCCH | 32.63 | 21440633 | |
| 367 | Phosphorylation | EILSAIESDSNKVKK HHHHHHHCCCHHHCC | 39.98 | 24961812 | |
| 369 | Phosphorylation | LSAIESDSNKVKKSK HHHHHCCCHHHCCCH | 48.07 | 24961812 | |
| 386 | Acetylation | KKHKLGTKYSVIDER CCCCCCCCCCHHCHH | 33.46 | 24489116 | |
| 388 | Phosphorylation | HKLGTKYSVIDERLE CCCCCCCCHHCHHHE | 17.72 | 30377154 | |
| 403 | Phosphorylation | IKFSDELSDSLRKLK EECCHHHHHHHHHHC | 24.09 | 21440633 | |
| 405 | Phosphorylation | FSDELSDSLRKLKPE CCHHHHHHHHHHCCC | 27.05 | 28889911 | |
| 428 | Acetylation | RKLQSSGKVETRVPV HHHHHCCCEEECCCC | 38.55 | 25381059 | |
| 448 | Acetylation | YKQKITEKWTHKDFK HHHHCCCCCCCCCCC | 49.06 | 22865919 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NOP53_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NOP53_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31, AND MASSSPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31, AND MASSSPECTROMETRY. | |
