| UniProt ID | CBF5_YEAST | |
|---|---|---|
| UniProt AC | P33322 | |
| Protein Name | H/ACA ribonucleoprotein complex subunit CBF5 | |
| Gene Name | CBF5 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 483 | |
| Subcellular Localization | Nucleus, nucleolus . Chromosome, centromere . Cytoplasm, cytoskeleton . | |
| Protein Description | Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. [PubMed: 10523634] | |
| Protein Sequence | MSKEDFVIKPEAAGASTDTSEWPLLLKNFDKLLVRSGHYTPIPAGSSPLKRDLKSYISSGVINLDKPSNPSSHEVVAWIKRILRCEKTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCIVRLHDALKDEKDLGRSLENLTGALFQRPPLISAVKRQLRVRTIYESNLIEFDNKRNLGVFWASCEAGTYMRTLCVHLGMLLGVGGHMQELRRVRSGALSENDNMVTLHDVMDAQWVYDNTRDESYLRSIIQPLETLLVGYKRIVVKDSAVNAVCYGAKLMIPGLLRYEEGIELYDEIVLITTKGEAIAVAIAQMSTVDLASCDHGVVASVKRCIMERDLYPRRWGLGPVAQKKKQMKADGKLDKYGRVNENTPEQWKKEYVPLDNAEQSTSSSQETKETEEEPKKAKEDSLIKEVETEKEEVKEDDSKKEKKEKKDKKEKKEKKEKKDKKEKKEKKEKKRKSEDGDSEEKKSKKSKK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSKEDFVIK ------CCHHHEEEC | 44.76 | 24961812 | |
| 3 | Acetylation | -----MSKEDFVIKP -----CCHHHEEECH | 61.06 | 24489116 | |
| 3 | Ubiquitination | -----MSKEDFVIKP -----CCHHHEEECH | 61.06 | 24961812 | |
| 9 | Ubiquitination | SKEDFVIKPEAAGAS CHHHEEECHHHCCCC | 31.35 | 23749301 | |
| 9 | Acetylation | SKEDFVIKPEAAGAS CHHHEEECHHHCCCC | 31.35 | 24489116 | |
| 31 | Acetylation | LLLKNFDKLLVRSGH HHHHCHHHHEECCCC | 39.31 | 24489116 | |
| 31 | Ubiquitination | LLLKNFDKLLVRSGH HHHHCHHHHEECCCC | 39.31 | 23749301 | |
| 36 | Phosphorylation | FDKLLVRSGHYTPIP HHHHEECCCCCCCCC | 23.57 | 21440633 | |
| 39 | Phosphorylation | LLVRSGHYTPIPAGS HEECCCCCCCCCCCC | 20.10 | 28889911 | |
| 40 | Phosphorylation | LVRSGHYTPIPAGSS EECCCCCCCCCCCCC | 14.74 | 22890988 | |
| 46 | Phosphorylation | YTPIPAGSSPLKRDL CCCCCCCCCCCHHHH | 30.78 | 22369663 | |
| 47 | Phosphorylation | TPIPAGSSPLKRDLK CCCCCCCCCCHHHHH | 33.08 | 22369663 | |
| 50 | Ubiquitination | PAGSSPLKRDLKSYI CCCCCCCHHHHHHHH | 47.45 | 23749301 | |
| 50 | Succinylation | PAGSSPLKRDLKSYI CCCCCCCHHHHHHHH | 47.45 | 23954790 | |
| 50 | Acetylation | PAGSSPLKRDLKSYI CCCCCCCHHHHHHHH | 47.45 | 24489116 | |
| 54 | Ubiquitination | SPLKRDLKSYISSGV CCCHHHHHHHHHCCC | 45.56 | 17644757 | |
| 66 | Ubiquitination | SGVINLDKPSNPSSH CCCCCCCCCCCCCHH | 54.21 | 17644757 | |
| 80 | Ubiquitination | HEVVAWIKRILRCEK HHHHHHHHHHHCCHH | 23.76 | 23749301 | |
| 80 | Acetylation | HEVVAWIKRILRCEK HHHHHHHHHHHCCHH | 23.76 | 24489116 | |
| 87 | Ubiquitination | KRILRCEKTGHSGTL HHHHCCHHCCCCCCC | 64.53 | 23749301 | |
| 114 | Ubiquitination | DRATRLVKSQQGAGK EHHHHHHHHCCCCCC | 47.33 | 23749301 | |
| 121 | Ubiquitination | KSQQGAGKEYVCIVR HHCCCCCCCEEEEEE | 45.39 | 23749301 | |
| 134 | Ubiquitination | VRLHDALKDEKDLGR EEHHHHHCCCHHHHH | 66.61 | 15699485 | |
| 134 | Acetylation | VRLHDALKDEKDLGR EEHHHHHCCCHHHHH | 66.61 | 22865919 | |
| 137 | Ubiquitination | HDALKDEKDLGRSLE HHHHCCCHHHHHHHH | 69.27 | 22106047 | |
| 161 | Acetylation | PPLISAVKRQLRVRT CHHHHHHHHHHHHHH | 33.86 | 24489116 | |
| 161 | Ubiquitination | PPLISAVKRQLRVRT CHHHHHHHHHHHHHH | 33.86 | 23749301 | |
| 180 | Acetylation | NLIEFDNKRNLGVFW CCEEECCCCCEEEEE | 44.50 | 24489116 | |
| 180 | Ubiquitination | NLIEFDNKRNLGVFW CCEEECCCCCEEEEE | 44.50 | 23749301 | |
| 254 | Phosphorylation | RDESYLRSIIQPLET CCHHHHHHHHHHHHH | 22.81 | 21440633 | |
| 267 | Ubiquitination | ETLLVGYKRIVVKDS HHHHCCCEEEEECHH | 29.71 | 23749301 | |
| 272 | Ubiquitination | GYKRIVVKDSAVNAV CCEEEEECHHHHHHH | 34.76 | 23749301 | |
| 284 | Ubiquitination | NAVCYGAKLMIPGLL HHHHHCCCHHCCCCC | 33.94 | 17644757 | |
| 358 | Ubiquitination | GLGPVAQKKKQMKAD CCCHHHHHHHHHHCC | 52.80 | 17644757 | |
| 359 | Ubiquitination | LGPVAQKKKQMKADG CCHHHHHHHHHHCCC | 35.84 | 17644757 | |
| 370 | Ubiquitination | KADGKLDKYGRVNEN HCCCCCCCCCCCCCC | 61.10 | 15699485 | |
| 371 | Phosphorylation | ADGKLDKYGRVNENT CCCCCCCCCCCCCCC | 15.16 | 21440633 | |
| 378 | Phosphorylation | YGRVNENTPEQWKKE CCCCCCCCHHHHHHH | 23.25 | 22369663 | |
| 383 | Ubiquitination | ENTPEQWKKEYVPLD CCCHHHHHHHCCCCC | 35.11 | 17644757 | |
| 384 | Ubiquitination | NTPEQWKKEYVPLDN CCHHHHHHHCCCCCC | 51.85 | 23749301 | |
| 384 | Acetylation | NTPEQWKKEYVPLDN CCHHHHHHHCCCCCC | 51.85 | 24489116 | |
| 386 | Phosphorylation | PEQWKKEYVPLDNAE HHHHHHHCCCCCCHH | 19.08 | 22890988 | |
| 395 | Phosphorylation | PLDNAEQSTSSSQET CCCCHHHCCCCCCCC | 23.05 | 22369663 | |
| 396 | Phosphorylation | LDNAEQSTSSSQETK CCCHHHCCCCCCCCC | 32.11 | 22369663 | |
| 397 | Phosphorylation | DNAEQSTSSSQETKE CCHHHCCCCCCCCCC | 32.99 | 25521595 | |
| 398 | Phosphorylation | NAEQSTSSSQETKET CHHHCCCCCCCCCCC | 35.81 | 22369663 | |
| 399 | Phosphorylation | AEQSTSSSQETKETE HHHCCCCCCCCCCCC | 31.63 | 22369663 | |
| 402 | Phosphorylation | STSSSQETKETEEEP CCCCCCCCCCCCCCC | 26.92 | 22369663 | |
| 403 | Acetylation | TSSSQETKETEEEPK CCCCCCCCCCCCCCH | 62.98 | 24489116 | |
| 403 | Ubiquitination | TSSSQETKETEEEPK CCCCCCCCCCCCCCH | 62.98 | 17644757 | |
| 405 | Phosphorylation | SSQETKETEEEPKKA CCCCCCCCCCCCHHH | 50.70 | 22369663 | |
| 416 | Phosphorylation | PKKAKEDSLIKEVET CHHHHHHHHHHHHHH | 32.84 | 25521595 | |
| 423 | Phosphorylation | SLIKEVETEKEEVKE HHHHHHHHHHHHHHC | 58.49 | 25521595 | |
| 468 | Phosphorylation | KKEKKRKSEDGDSEE HHHHHHHCCCCCHHH | 44.98 | 27717283 | |
| 473 | Phosphorylation | RKSEDGDSEEKKSKK HHCCCCCHHHHHHHH | 53.86 | 27214570 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 399 | S | Phosphorylation | Kinase | ATM/ATR | - | GPS |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CBF5_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CBF5_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-47; THR-378; THR-396;SER-397; SER-398; SER-399 AND THR-402, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-378; SER-399 ANDTHR-405, AND MASS SPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-47 AND THR-378, AND MASSSPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-378, AND MASSSPECTROMETRY. | |
