RPA43_YEAST - dbPTM
RPA43_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RPA43_YEAST
UniProt AC P46669
Protein Name DNA-directed RNA polymerase I subunit RPA43
Gene Name RPA43
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 326
Subcellular Localization Nucleus, nucleolus .
Protein Description DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I (Pol I) which synthesizes ribosomal RNA precursors. Besides, RNA polymerase I has intrinsic RNA cleavage activity. Through its association with RRN3 is involved in recruitment of Pol I to rDNA promoters. In vitro, the A13-A43 subcomplex binds single-stranded RNA..
Protein Sequence MSQVKRANENRETARFIKKHKKQVTNPIDEKNGTSNCIVRVPIALYVSLAPMYLENPLQGVMKQHLNPLVMKYNNKVGGVVLGYEGLKILDADPLSKEDTSEKLIKITPDTPFGFTWCHVNLYVWQPQVGDVLEGYIFIQSASHIGLLIHDAFNASIKKNNIPVDWTFVHNDVEEDADVINTDENNGNNNNEDNKDSNGGSNSLGKFSFGNRSLGHWVDSNGEPIDGKLRFTVRNVHTTGRVVSVDGTLISDADEEGNGYNSSRSQAESLPIVSNKKIVFDDEVSIENKESHKELDLPEVKEDNGSEIVYEENTSESNDGESSDSD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
25PhosphorylationKKHKKQVTNPIDEKN
HHHHHHCCCCCCCCC		32.5528889911
31AcetylationVTNPIDEKNGTSNCI
CCCCCCCCCCCCCEE		57.8624489116
72AcetylationHLNPLVMKYNNKVGG
HHCHHHHHCCCCCCE		37.0324489116
88UbiquitinationVLGYEGLKILDADPL
EEEECCEEEEECCCC		52.6724961812
96PhosphorylationILDADPLSKEDTSEK
EEECCCCCCCCCCCC		39.1121440633
97AcetylationLDADPLSKEDTSEKL
EECCCCCCCCCCCCC		68.2624489116
103AcetylationSKEDTSEKLIKITPD
CCCCCCCCCEECCCC		56.1124489116
203PhosphorylationDSNGGSNSLGKFSFG
CCCCCCCCCCEEECC		39.9528889911
206AcetylationGGSNSLGKFSFGNRS
CCCCCCCEEECCCCC		43.0324489116
208PhosphorylationSNSLGKFSFGNRSLG
CCCCCEEECCCCCCC		35.4128889911
220PhosphorylationSLGHWVDSNGEPIDG
CCCCEECCCCCCCCC		36.8028889911
228AcetylationNGEPIDGKLRFTVRN
CCCCCCCEEEEEEEE		32.5124489116
244PhosphorylationHTTGRVVSVDGTLIS
CCCCCEEEEECEEEC		16.1922369663
248PhosphorylationRVVSVDGTLISDADE
CEEEEECEEECCCCC		19.2222369663
251PhosphorylationSVDGTLISDADEEGN
EEECEEECCCCCCCC		29.8322369663
260PhosphorylationADEEGNGYNSSRSQA
CCCCCCCCCCCHHHH		18.8322369663
262PhosphorylationEEGNGYNSSRSQAES
CCCCCCCCCHHHHHC		20.7422369663
263PhosphorylationEGNGYNSSRSQAESL
CCCCCCCCHHHHHCC		32.1122369663
265PhosphorylationNGYNSSRSQAESLPI
CCCCCCHHHHHCCCE		35.3722369663
269PhosphorylationSSRSQAESLPIVSNK
CCHHHHHCCCEECCC		42.3222369663
274PhosphorylationAESLPIVSNKKIVFD
HHCCCEECCCEEEEC		43.5922369663
276AcetylationSLPIVSNKKIVFDDE
CCCEECCCEEEECCC		36.0525381059
285PhosphorylationIVFDDEVSIENKESH
EEECCCCCCCCHHHC		23.3322369663
293AcetylationIENKESHKELDLPEV
CCCHHHCCCCCCCCC		70.0625381059
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RPA43_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RPA43_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RPA43_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RPA14_YEASTRPA14physical
12407181
FKBP3_YEASTFPR3physical
10791972
FBRL_YEASTNOP1physical
10791972
REB1_YEASTREB1physical
10791972
TBP_YEASTSPT15physical
10791972
RRP5_YEASTRRP5physical
10791972
RPA1_YEASTRPA190physical
10791972
RPA2_YEASTRPA135physical
10791972
CBF5_YEASTCBF5physical
10791972
FKBP4_YEASTFPR4physical
10791972
RPA49_YEASTRPA49physical
10791972
RS10B_YEASTRPS10Bphysical
10791972
RS7A_YEASTRPS7Aphysical
10791972
NHP2_YEASTNHP2physical
10791972
RPA14_YEASTRPA14physical
10791972
RPA14_YEASTRPA14genetic
12407181
TOP3_YEASTTOP3genetic
12374750
NET1_YEASTNET1physical
16554755
RPAC2_YEASTRPC19physical
16554755
RPA1_YEASTRPA190physical
16554755
RPA2_YEASTRPA135physical
16554755
RPAC1_YEASTRPC40physical
16554755
RPAB2_YEASTRPO26physical
16554755
RPA12_YEASTRPA12physical
16429126
RPA2_YEASTRPA135physical
16429126
RPA1_YEASTRPA190physical
16429126
RPAB1_YEASTRPB5physical
16429126
RPAB3_YEASTRPB8physical
16429126
RPAC1_YEASTRPC40physical
16429126
CIN8_YEASTCIN8genetic
17314980
SAC1_YEASTSAC1genetic
17314980
CG21_YEASTCLB1genetic
17314980
THP2_YEASTTHP2genetic
17314980
ISW2_YEASTISW2genetic
17314980
LSM1_YEASTLSM1genetic
17314980
MFT1_YEASTMFT1genetic
17314980
BIM1_YEASTBIM1genetic
17314980
RPA14_YEASTRPA14genetic
17314980
PAT1_YEASTPAT1genetic
17314980
SIC1_YEASTSIC1genetic
17314980
RAD5_YEASTRAD5genetic
17314980
H2A1_YEASTHTA1genetic
17314980
GCR2_YEASTGCR2genetic
17314980
VPS64_YEASTVPS64genetic
17314980
CSM3_YEASTCSM3genetic
17314980
EAF6_YEASTEAF6genetic
17314980
GCN20_YEASTGCN20genetic
17314980
MRC1_YEASTMRC1genetic
17314980
SAC3_YEASTSAC3genetic
17314980
LEO1_YEASTLEO1genetic
17314980
PP4R3_YEASTPSY2genetic
17314980
ASK10_YEASTASK10genetic
17314980
NUP60_YEASTNUP60genetic
17314980
REV7_YEASTREV7genetic
17314980
UBP3_YEASTUBP3genetic
17314980
MDM35_YEASTMDM35genetic
17314980
IRA2_YEASTIRA2genetic
17314980
LRP1_YEASTLRP1genetic
17314980
RRP6_YEASTRRP6genetic
17314980
TIM13_YEASTTIM13genetic
17314980
HPC2_YEASTHPC2genetic
17314980
RPA12_YEASTRPA12physical
18160037
RPA2_YEASTRPA135physical
18160037
RPA14_YEASTRPA14physical
18160037
RPA1_YEASTRPA190physical
18160037
RPA34_YEASTRPA34physical
18160037
RPA49_YEASTRPA49physical
18160037
RPAB5_YEASTRPB10physical
18160037
RPAB1_YEASTRPB5physical
18160037
RPAB3_YEASTRPB8physical
18160037
RPAB4_YEASTRPC10physical
18160037
RPAC2_YEASTRPC19physical
18160037
RPAC1_YEASTRPC40physical
18160037
RPAB2_YEASTRPO26physical
18160037
RPA14_YEASTRPA14physical
21983101
SPT5_YEASTSPT5physical
21983101
SPT6_YEASTSPT6physical
21983101
SPT6_YEASTSPT6genetic
21983101
RPA2_YEASTRPA135physical
24153184
RPC6_YEASTRPC34genetic
27708008
TFS2_YEASTDST1genetic
27708008
RL6B_YEASTRPL6Bgenetic
27708008
EAF7_YEASTEAF7genetic
27708008
STU1_YEASTSTU1genetic
27708008
PRP6_YEASTPRP6genetic
27708008
KRR1_YEASTKRR1genetic
27708008
SUB2_YEASTSUB2genetic
27708008
UAP1_YEASTQRI1genetic
27708008
KIN28_YEASTKIN28genetic
27708008
DAD1_YEASTDAD1genetic
27708008
DBF4_YEASTDBF4genetic
27708008
CDC1_YEASTCDC1genetic
27708008
SP105_YEASTSPC105genetic
27708008
CDC20_YEASTCDC20genetic
27708008
DAM1_YEASTDAM1genetic
27708008
ATC7_YEASTNEO1genetic
27708008
KRE9_YEASTKRE9genetic
27708008
FIP1_YEASTFIP1genetic
27708008
SEN1_YEASTSEN1genetic
27708008
POB3_YEASTPOB3genetic
27708008
SPC24_YEASTSPC24genetic
27708008
MVD1_YEASTMVD1genetic
27708008
THIL_YEASTERG10genetic
27708008
IPL1_YEASTIPL1genetic
27708008
BUR1_YEASTSGV1genetic
27708008
ATC3_YEASTDRS2genetic
27708008
GBP2_YEASTGBP2genetic
27708008
PAT1_YEASTPAT1genetic
27708008
PP2C1_YEASTPTC1genetic
27708008
FMP45_YEASTFMP45genetic
27708008
VPS41_YEASTVPS41genetic
27708008
RPA14_YEASTRPA14genetic
27708008
SAC3_YEASTSAC3genetic
27708008
PUF4_YEASTPUF4genetic
27708008
ATC1_YEASTPMR1genetic
27708008
HUR1_YEASTHUR1genetic
27708008
VAM7_YEASTVAM7genetic
27708008
SCM4_YEASTSCM4genetic
27708008
YG1X_YEASTYGR050Cgenetic
27708008
VMA21_YEASTVMA21genetic
27708008
SNF6_YEASTSNF6genetic
27708008
THP2_YEASTTHP2genetic
27708008
STB5_YEASTSTB5genetic
27708008
AIM18_YEASTAIM18genetic
27708008
RPA34_YEASTRPA34genetic
27708008
DAS1_YEASTDAS1genetic
27708008
HOC1_YEASTHOC1genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
UBL1_YEASTYUH1genetic
27708008
ILM1_YEASTILM1genetic
27708008
CTK1_YEASTCTK1genetic
27708008
NDE1_YEASTNDL1genetic
27708008
MMS22_YEASTMMS22genetic
27708008
ATP10_YEASTATP10genetic
27708008
SST2_YEASTSST2genetic
27708008
TRI1_YEASTTRI1genetic
27708008
MAS5_YEASTYDJ1genetic
27708008
YNO0_YEASTYNL140Cgenetic
27708008
SUR1_YEASTSUR1genetic
27708008
YP096_YEASTYPR096Cgenetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RPA43_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-285, AND MASSSPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-285, AND MASSSPECTROMETRY.
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-244; SER-251; TYR-260;SER-262; SER-263; SER-265; SER-269 AND SER-285, AND MASS SPECTROMETRY.

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