DAS1_YEAST - dbPTM
DAS1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DAS1_YEAST
UniProt AC P47005
Protein Name F-box protein DAS1
Gene Name DAS1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 663
Subcellular Localization
Protein Description Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity)..
Protein Sequence MPFQDYFQKKKAAFINRNNKSNADASALRDINDININFAAKSKNYVFPLTKLPDELMQEVFSHLPQPDRLQLCLVNKRLNKIATKLLYRRIYLNDSNVVKSDFMHLAINWTLLNLPSSLKEEESRDIANCKLKKLIETLQNNIHITEVIQWIRINWDLDSTLQRSILSILCNQGKSLQRLENVTDPACNDIISNGHFSRSNVSSFDMAPPNSLPEMVVPENYIPNLTKYLSQRISSRLSHMTLFIDPLKLFNYLYPLDIKLQIIDLKLHWRREFYNNDYFVKKIRPGNPLTKLSEVFDKRTLKILTIISWNDTLLKRETEMLKDFKEFENLEDLSLISIKQDVHILVDLFSSLTNLKRLKMDFLEEYVPEPTNPHIFLSILLACSKLQFIDLRYDGLIPQIINIQENKFQLNQQCNCTNCQIVFSDILKGKIFMFPEDYYIHDLQDIAAKDIFKMMKYLSLLPYSKACDAYPSVRTQPMNLTNFVTKMNRNLLEYRNSKSQLVPKIVNNPHQHSTVTSTSTAHMSEPEMIIIDDDDDDDEINAAIPPSSDDTAATISTDLELPHESLTKRDIIMCYHALIHHFKSIYVTFLKSFPHLRFLMLNDIPTIVMEENNERIFEPVFYHYDYKSNLYGWSKESNKNLENDSNNNNNNSDTIARIATVM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
21PhosphorylationFINRNNKSNADASAL
HHCCCCCCCCCHHHH		39.1023749301
175UbiquitinationSILCNQGKSLQRLEN
HHHCCCCHHHHHHHH		37.9217644757
323SuccinylationKRETEMLKDFKEFEN
HHHHHHHHCHHHHCC		60.8623954790
486PhosphorylationMNLTNFVTKMNRNLL
CCHHHHHHHHHHHHH		22.0424909858
628UbiquitinationVFYHYDYKSNLYGWS
EEEECCCCCCCCCCC		29.9417644757
640UbiquitinationGWSKESNKNLENDSN
CCCHHCCCCCCCCCC		72.6623749301
646PhosphorylationNKNLENDSNNNNNNS
CCCCCCCCCCCCCCH		53.7023749301
653PhosphorylationSNNNNNNSDTIARIA
CCCCCCCHHHHHHHH		37.9528889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DAS1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DAS1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DAS1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SKP1_YEASTSKP1physical
11805837
CDC53_YEASTCDC53physical
11805837
CDC53_YEASTCDC53physical
10582239
SKP1_YEASTSKP1physical
10582239
LAG2_YEASTLAG2physical
19763088
MSC1_YEASTMSC1genetic
19325107
SEC66_YEASTSEC66genetic
19325107
SPT4_YEASTSPT4genetic
19325107
MIG2_YEASTMIG2genetic
21323640
GAL80_YEASTGAL80genetic
22479149
UFO1_YEASTUFO1genetic
22479149
MDM30_YEASTMDM30genetic
22479149
CDC24_YEASTCDC24genetic
27708008
DPOA2_YEASTPOL12genetic
27708008
APC11_YEASTAPC11genetic
27708008
UAP1_YEASTQRI1genetic
27708008
PDC2_YEASTPDC2genetic
27708008
CDC1_YEASTCDC1genetic
27708008
BET3_YEASTBET3genetic
27708008
BET5_YEASTBET5genetic
27708008
LIP1_YEASTLIP1genetic
27708008
NAB3_YEASTNAB3genetic
27708008
SLT2_YEASTSLT2genetic
27708008
MNS1_YEASTMNS1genetic
27708008
UBR2_YEASTUBR2genetic
27708008
CSF1_YEASTCSF1genetic
27708008
MSC1_YEASTMSC1genetic
27708008
YNL5_YEASTYNL115Cgenetic
27708008
TRM44_YEASTTRM44genetic
27708008
NEW1_YEASTNEW1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DAS1_YEAST

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Related Literatures of Post-Translational Modification

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