dbPTM

YNL5_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	YNL5_YEAST
UniProt AC	P53925
Protein Name	Uncharacterized vacuolar membrane protein YNL115C
Gene Name	YNL115C
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	644
Subcellular Localization	Vacuole membrane Multi-pass membrane protein .
Protein Description
Protein Sequence	MKANGLDNDPARTGMERTDIDSEHPEAQPLLNNNHRTLGAGSANGPAVNEGRDIESDGFIKDSLFQIRKGYRIFIHNSKWILNILILINTIWLVTTLISDFFFNINILFGFSNRYASFNDLTLIFISIIANSFNLWFNKLGLYSALDYSLNVTLCVLTLFNLALTYLIKYTRQRIGFVGTFTYLWTSFSFFIGAILDWYLLFYNNSINEPLEERRIDDANISTFNENHTNSTENRDRSQYGSGSPTPTHRSQLVQNKHTLTEWVSIGFRNTIKFLILIFFALFTLNTLLTTLDTYRLTHKLPITVQSPSYEAFHYVDAAKTYQLHITCYGDVFDQENNTDLSENKKQPIILFEHGGYDTGYLSATWIEELYHLDKIQRYCLYDRPGYGLSDSPPAPISIAMVAESLRYALIKDAKIKGPFTTVGYDLGGLFTRVFTAKNVDIVDSMMLVESWHEELLLKNYIQRLLPPGRGDGDDGDDGNGNDGDGRNHDKTWLPSEIERHNEFRLWWKGIWSSLGWRLQTSWLLAHHGSKERIYGRDMKYQGRFLRSKFLESVTSSILSYRDVTNNAESLQNVKTSIVSSKEMVKKSALWGDWQRDLTKISHKTQEWKIVEGGHEIYKYGLGKQQTQEVLLRLIGELGKLTED

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Ubiquitination	------MKANGLDND ------CCCCCCCCC	51.03	23749301
18	Phosphorylation	ARTGMERTDIDSEHP HHCCCCCCCCCCCCC	24.81	19779198
22	Phosphorylation	MERTDIDSEHPEAQP CCCCCCCCCCCCCCC	37.83	25704821
37	Phosphorylation	LLNNNHRTLGAGSAN CCCCCCCCCCCCCCC	23.22	29136822
42	Phosphorylation	HRTLGAGSANGPAVN CCCCCCCCCCCCCCC	20.30	24930733
56	Phosphorylation	NEGRDIESDGFIKDS CCCCCCCCCCCCCCC	43.28	22369663
63	Phosphorylation	SDGFIKDSLFQIRKG CCCCCCCCHHHHHCC	26.53	28889911
222	Phosphorylation	RIDDANISTFNENHT CCCCCCHHCCCCCCC	27.10	29136822
223	Phosphorylation	IDDANISTFNENHTN CCCCCHHCCCCCCCC	27.04	29136822
229	Phosphorylation	STFNENHTNSTENRD HCCCCCCCCCCCCCC	42.31	28889911
232	Phosphorylation	NENHTNSTENRDRSQ CCCCCCCCCCCCHHH	39.07	28889911
238	Phosphorylation	STENRDRSQYGSGSP CCCCCCHHHCCCCCC	31.85	22369663
240	Phosphorylation	ENRDRSQYGSGSPTP CCCCHHHCCCCCCCC	17.95	22369663
242	Phosphorylation	RDRSQYGSGSPTPTH CCHHHCCCCCCCCCC	31.03	22369663
244	Phosphorylation	RSQYGSGSPTPTHRS HHHCCCCCCCCCCHH	27.57	22369663
246	Phosphorylation	QYGSGSPTPTHRSQL HCCCCCCCCCCHHHH	42.38	22369663
248	Phosphorylation	GSGSPTPTHRSQLVQ CCCCCCCCCHHHHHH	32.19	22369663
251	Phosphorylation	SPTPTHRSQLVQNKH CCCCCCHHHHHHCCC	21.91	22369663
357	Phosphorylation	ILFEHGGYDTGYLSA EEEECCCCCCCCCCH	18.22	30377154
359	Phosphorylation	FEHGGYDTGYLSATW EECCCCCCCCCCHHH	21.17	30377154
361	Phosphorylation	HGGYDTGYLSATWIE CCCCCCCCCCHHHHH	10.28	30377154
363	Phosphorylation	GYDTGYLSATWIEEL CCCCCCCCHHHHHHH	18.37	30377154
365	Phosphorylation	DTGYLSATWIEELYH CCCCCCHHHHHHHHC	24.49	30377154
371	Phosphorylation	ATWIEELYHLDKIQR HHHHHHHHCHHHHHH	12.01	30377154
576	Phosphorylation	ESLQNVKTSIVSSKE HHHHHHCHHHHCCHH	21.28	21126336
577	Phosphorylation	SLQNVKTSIVSSKEM HHHHHCHHHHCCHHH	18.44	21126336
619	Acetylation	EGGHEIYKYGLGKQQ ECCHHHHHCCCCCHH	38.20	24489116

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of YNL5_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of YNL5_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of YNL5_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GPR1_YEAST	GPR1	genetic	27708008
UBP3_YEAST	UBP3	genetic	27708008
SNF6_YEAST	SNF6	genetic	27708008
RS27B_YEAST	RPS27B	genetic	27708008
DAL81_YEAST	DAL81	genetic	27708008
IXR1_YEAST	IXR1	genetic	27708008
NCBP2_YEAST	CBC2	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of YNL5_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42; SER-56; SER-242 ANDSER-244, AND MASS SPECTROMETRY.	18407956 [Abstract]
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-56 AND SER-244, AND MASSSPECTROMETRY.	17563356 [Abstract]