| UniProt ID | GAL80_YEAST | |
|---|---|---|
| UniProt AC | P04387 | |
| Protein Name | Galactose/lactose metabolism regulatory protein GAL80 | |
| Gene Name | GAL80 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 435 | |
| Subcellular Localization | ||
| Protein Description | This protein is a negative regulator for the gene expression of the lactose/galactose metabolic genes. It binds to GAL4 and so blocks transcriptional activation by it, in the absence of an inducing sugar.. | |
| Protein Sequence | MDYNKRSSVSTVPNAAPIRVGFVGLNAAKGWAIKTHYPAILQLSSQFQITALYSPKIETSIATIQRLKLSNATAFPTLESFASSSTIDMIVIAIQVASHYEVVMPLLEFSKNNPNLKYLFVEWALACSLDQAESIYKAAAERGVQTIISLQGRKSPYILRAKELISQGYIGDINSIEIAGNGGWYGYERPVKSPKYIYEIGNGVDLVTTTFGHTIDILQYMTSSYFSRINAMVFNNIPEQELIDERGNRLGQRVPKTVPDHLLFQGTLLNGNVPVSCSFKGGKPTKKFTKNLVIDIHGTKGDLKLEGDAGFAEISNLVLYYSGTRANDFPLANGQQAPLDPGYDAGKEIMEVYHLRNYNAIVGNIHRLYQSISDFHFNTKKIPELPSQFVMQGFDFEGFPTLMDALILHRLIESVYKSNMMGSTLNVSNISHYSL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MDYNKRSS -------CCCCCCCC | 12.76 | 1985957 | |
| 7 | Phosphorylation | -MDYNKRSSVSTVPN -CCCCCCCCCCCCCC | 36.38 | 19779198 | |
| 8 | Phosphorylation | MDYNKRSSVSTVPNA CCCCCCCCCCCCCCC | 24.91 | 25752575 | |
| 10 | Phosphorylation | YNKRSSVSTVPNAAP CCCCCCCCCCCCCCC | 26.15 | 19779198 | |
| 11 | Phosphorylation | NKRSSVSTVPNAAPI CCCCCCCCCCCCCCC | 37.51 | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GAL80_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GAL80_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GAL80_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Acetylation | |
| Reference | PubMed |
| "Purification and characterization of the yeast negative regulatoryprotein GAL80."; Yun S.-J., Hiraoka Y., Nishizawa M., Takio K., Titani K., Nogi Y.,Fukasawa T.; J. Biol. Chem. 266:693-697(1991). Cited for: PROTEIN SEQUENCE OF 29-33; 162-171 AND 410-416, FUNCTION, SUBUNIT, ANDACETYLATION AT MET-1. | |
