PHO2_YEAST - dbPTM
PHO2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PHO2_YEAST
UniProt AC P07269
Protein Name Regulatory protein PHO2
Gene Name PHO2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 559
Subcellular Localization Nucleus.
Protein Description Regulator in phosphate metabolism and acts as a derepressor of another central regulator PHO5. Binds to the upstream activator sequence (UAS) of PHO5. It also binds to the TRP4, HIS4, and CYC1 promoters..
Protein Sequence MMEEFSYDHDFNTHFATDLDYLQHDQQQQQQQQHDQQHNQQQQPQPQPIQTQNLEHDHDQHTNDMSASSNASDSGPQRPKRTRAKGEALDVLKRKFEINPTPSLVERKKISDLIGMPEKNVRIWFQNRRAKLRKKQHGSNKDTIPSSQSRDIANDYDRGSTDNNLVTTTSTSSIFHDEDLTFFDRIPLNSNNNYYFFDICSITVGSWNRMKSGALQRRNFQSIKELRNLSPIKINNIMSNATDLMVLISKKNSEINYFFSAMANNTKILFRIFFPLSSVTNCSLTLETDDDIINSNNTSDKNNSNTNNDDDNDDNSNEDNDNSSEDKRNAKDNFGELKLTVTRSPTFAVYFLNNAPDEDPNLNNQWSICDDFSEGRQVNDAFVGGSNIPHTLKGLQKSLRFMNSLILDYKSSNEILPTINTAIPTAAVPQQNIAPPFLNTNSSATDSNPNTNLEDSLFFDHDLLSSSITNTNNGQGSNNGRQASKDDTLNLLDTTVNSNNNHNANNEENHLAQEHLSNDADIVANPNDHLLSLPTDSELPNTPDFLKNTNELTDEHRWI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
66PhosphorylationDQHTNDMSASSNASD
CCCCCCCCCCCCCCC		28.0627017623
68PhosphorylationHTNDMSASSNASDSG
CCCCCCCCCCCCCCC		19.4727017623
69PhosphorylationTNDMSASSNASDSGP
CCCCCCCCCCCCCCC		35.8127017623
146PhosphorylationSNKDTIPSSQSRDIA
CCCCCCCCHHHHCCH		36.8427214570
147PhosphorylationNKDTIPSSQSRDIAN
CCCCCCCHHHHCCHH		27.1627214570
149PhosphorylationDTIPSSQSRDIANDY
CCCCCHHHHCCHHCC		33.5930377154
170PhosphorylationNNLVTTTSTSSIFHD
CCEEECCCCCCCCCC		24.9719779198
171PhosphorylationNLVTTTSTSSIFHDE
CEEECCCCCCCCCCC		25.1319779198
173PhosphorylationVTTTSTSSIFHDEDL
EECCCCCCCCCCCCC		29.3919779198
194PhosphorylationPLNSNNNYYFFDICS
ECCCCCCEEEEEEEE		12.0828889911
195PhosphorylationLNSNNNYYFFDICSI
CCCCCCEEEEEEEEE		10.4128889911
201PhosphorylationYYFFDICSITVGSWN
EEEEEEEEEEECCHH		22.9428889911
224AcetylationRRNFQSIKELRNLSP
HCCHHHHHHHHCCCC		56.8124489116
230PhosphorylationIKELRNLSPIKINNI
HHHHHCCCCCEEHHH		28.2928889911
239PhosphorylationIKINNIMSNATDLMV
CEEHHHHCCCCCEEE		21.3729136822
242PhosphorylationNNIMSNATDLMVLIS
HHHHCCCCCEEEEEE		33.6429136822
249PhosphorylationTDLMVLISKKNSEIN
CCEEEEEECCCHHHH		33.1629136822
253PhosphorylationVLISKKNSEINYFFS
EEEECCCHHHHHHHH		49.0529136822
257PhosphorylationKKNSEINYFFSAMAN
CCCHHHHHHHHHHCC		16.2129136822
260PhosphorylationSEINYFFSAMANNTK
HHHHHHHHHHCCCCE		13.7729136822
266PhosphorylationFSAMANNTKILFRIF
HHHHCCCCEEEEEEE		21.1929136822
306PhosphorylationSDKNNSNTNNDDDND
CCCCCCCCCCCCCCC		34.9128889911
316PhosphorylationDDDNDDNSNEDNDNS
CCCCCCCCCCCCCCC		48.9023749301
323PhosphorylationSNEDNDNSSEDKRNA
CCCCCCCCHHHHHHH		37.6628889911
324PhosphorylationNEDNDNSSEDKRNAK
CCCCCCCHHHHHHHH		56.9528889911
386PhosphorylationNDAFVGGSNIPHTLK
CCCCCCCCCCCHHHH		26.1722369663
391PhosphorylationGGSNIPHTLKGLQKS
CCCCCCHHHHHHHHH		25.4722369663
542PhosphorylationTDSELPNTPDFLKNT
CCCCCCCCCHHHHCH		23.4627214570
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PHO2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PHO2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PHO2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SWI5_YEASTSWI5physical
9111337
SWI5_YEASTSWI5physical
7493941
SWI5_YEASTSWI5physical
8355698
SWI5_YEASTSWI5physical
7902583
PHO4_YEASTPHO4physical
12136204
TBP_YEASTSPT15physical
9354395
TF2B_YEASTSUA7physical
9354395
T2EB_YEASTTFA2physical
9354395
PHO4_YEASTPHO4physical
7957107
PHO4_YEASTPHO4physical
12219216
PPA5_YEASTPHO5physical
12237689
PHO4_YEASTPHO4physical
10884387
ELP1_YEASTIKI3physical
15175650
RL35A_YEASTRPL35Aphysical
14660704
RL35B_YEASTRPL35Aphysical
14660704
RS5_YEASTRPS5physical
14660704
YB11A_YEASTYBL005W-Aphysical
14660704
YD17A_YEASTYDR170W-Aphysical
14660704
YD23B_YEASTYDR261W-Bphysical
14660704
YO11A_YEASTYOL103W-Aphysical
14660704
YL14A_YEASTYLR256W-Aphysical
14660704
YJ11A_YEASTYLR227W-Aphysical
14660704
YL13A_YEASTYLR227W-Aphysical
14660704
YM12A_YEASTYLR227W-Aphysical
14660704
YD15A_YEASTYLR157C-Aphysical
14660704
YE11A_YEASTYLR157C-Aphysical
14660704
YL12A_YEASTYLR157C-Aphysical
14660704
YP11A_YEASTYLR157C-Aphysical
14660704
YJ12A_YEASTYJR028Wphysical
14660704
YM13B_YEASTYMR045Cphysical
14660704
YN11B_YEASTYNL284C-Bphysical
14660704
PHO4_YEASTPHO4physical
19528318
BAS1_YEASTBAS1physical
19528318
PUR8_YEASTADE13physical
19528318
PHO4_YEASTPHO4genetic
3049251
PHO4_YEASTPHO4genetic
2196175
PHO4_YEASTPHO4physical
20828586
UBP3_YEASTUBP3genetic
20959818
VPS8_YEASTVPS8genetic
27708008
COX5A_YEASTCOX5Agenetic
27708008
ADE_YEASTAAH1genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
CDK1_YEASTCDC28genetic
27708008
NSE3_YEASTNSE3genetic
27708008
GPI8_YEASTGPI8genetic
27708008
MOB2_YEASTMOB2genetic
27708008
CDC6_YEASTCDC6genetic
27708008
IF2A_YEASTSUI2genetic
27708008
DYR_YEASTDFR1genetic
27708008
MED10_YEASTNUT2genetic
27708008
DEP1_YEASTDEP1genetic
27708008
RKM3_YEASTRKM3genetic
27708008
CSG2_YEASTCSG2genetic
27708008
ADPP_YEASTYSA1genetic
27708008
ISW1_YEASTISW1genetic
27708008
SNF5_YEASTSNF5genetic
27708008
AGP1_YEASTAGP1genetic
27708008
RV161_YEASTRVS161genetic
27708008
SNT1_YEASTSNT1genetic
27708008
ELO2_YEASTELO2genetic
27708008
YCV1_YEASTYCR061Wgenetic
27708008
PMP3_YEASTPMP3genetic
27708008
IPK1_YEASTIPK1genetic
27708008
LSM6_YEASTLSM6genetic
27708008
RV167_YEASTRVS167genetic
27708008
HPRT_YEASTHPT1genetic
27708008
CHAC_YEASTGCG1genetic
27708008
GCN20_YEASTGCN20genetic
27708008
SGF73_YEASTSGF73genetic
27708008
AAKG_YEASTSNF4genetic
27708008
MED5_YEASTNUT1genetic
27708008
GCN1_YEASTGCN1genetic
27708008
RL24B_YEASTRPL24Bgenetic
27708008
NEM1_YEASTNEM1genetic
27708008
STB5_YEASTSTB5genetic
27708008
AIM18_YEASTAIM18genetic
27708008
GPI7_YEASTLAS21genetic
27708008
DLS1_YEASTDLS1genetic
27708008
MOG1_YEASTMOG1genetic
27708008
VPS24_YEASTVPS24genetic
27708008
CYT2_YEASTCYT2genetic
27708008
SAC1_YEASTSAC1genetic
27708008
EI2BA_YEASTGCN3genetic
27708008
UBR2_YEASTUBR2genetic
27708008
AVL9_YEASTAVL9genetic
27708008
RS30A_YEASTRPS30Agenetic
27708008
RS30B_YEASTRPS30Agenetic
27708008
ARPC3_YEASTARC18genetic
27708008
VIP1_YEASTVIP1genetic
27708008
MUB1_YEASTMUB1genetic
27708008
COX7_YEASTCOX7genetic
27708008
AEP2_YEASTAEP2genetic
27708008
FYV12_YEASTFYV12genetic
27708008
PNT1_YEASTPNT1genetic
27708008
LGE1_YEASTLGE1genetic
27708008
SUR1_YEASTSUR1genetic
27708008
YP066_YEASTRGL1genetic
27708008
ISU1_YEASTISU1genetic
27708008
AIM44_YEASTAIM44genetic
27708008
NCBP2_YEASTCBC2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PHO2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-146 AND THR-542, ANDMASS SPECTROMETRY.

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