DLS1_YEAST - dbPTM
DLS1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DLS1_YEAST
UniProt AC P40366
Protein Name Protein DLS1
Gene Name DLS1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 167
Subcellular Localization Nucleus .
Protein Description Functions as component of the ISW2 complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW2 complex is involved in coordinating transcriptional repression and in inheritance of telomeric silencing. It is involved in repression of MAT a-specific genes, INO1, and early meiotic genes during mitotic growth dependent upon transcription factor UME6 and in a parallel pathway to the RPD3-SIN3 histone deacetylase complex. DLS1 is partially required for the ISW2 complex chromatin remodeling activity and is not required for its interaction with chromatin..
Protein Sequence MNNETSGKETASAPLCSPKLPVEKVQRIAKNDPEYMDTSDDAFVATAFATEFFVQVLTHESLHRQQQQQQQQVPPLPDELTLSYDDISAAIVHSSDGHLQFLNDVIPTTKNLRLLVEENRVRYTTSVMPPNEVYSAYVVNDTAPKPNIVEIDLDNDEDDDEDVTDQE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Phosphorylation---MNNETSGKETAS
---CCCCCCCCCCCC		44.9230377154
10PhosphorylationNETSGKETASAPLCS
CCCCCCCCCCCCCCC		29.4228132839
12PhosphorylationTSGKETASAPLCSPK
CCCCCCCCCCCCCCC		37.5328132839
17PhosphorylationTASAPLCSPKLPVEK
CCCCCCCCCCCCHHH		32.5221551504
164PhosphorylationEDDDEDVTDQE----
CCCCCCCCCCC----		44.2619795423
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DLS1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DLS1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DLS1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DPB4_YEASTDPB4physical
14673157
ISW2_YEASTISW2physical
14673157
ITC1_YEASTITC1physical
14673157
ITC1_YEASTITC1physical
15024052
ISW2_YEASTISW2physical
15024052
DPB4_YEASTDPB4physical
16554755
ISW2_YEASTISW2physical
16554755
MFT1_YEASTMFT1physical
16554755
ELOA1_YEASTELA1physical
16554755
NHP10_YEASTNHP10genetic
21930788
SLX8_YEASTSLX8genetic
27708008
MSH4_YEASTMSH4genetic
27708008
RL14A_YEASTRPL14Agenetic
27708008
IXR1_YEASTIXR1genetic
27708008
YL278_YEASTYLR278Cgenetic
27708008
TYE7_YEASTTYE7genetic
27708008
FRE5_YEASTFRE5genetic
27708008
NIP80_YEASTNIP100genetic
27708008
YP245_YEASTYPL245Wgenetic
27708008
SWC3_YEASTSWC3genetic
27708008
DEP1_YEASTDEP1genetic
27708008
RL19A_YEASTRPL19Bgenetic
27708008
RL19B_YEASTRPL19Bgenetic
27708008
PIN4_YEASTPIN4genetic
27708008
NU170_YEASTNUP170genetic
27708008
SWC5_YEASTSWC5genetic
27708008
YCA2_YEASTYCL002Cgenetic
27708008
HAL4_YEASTSAT4genetic
27708008
YCY0_YEASTYCR090Cgenetic
27708008
RS29B_YEASTRPS29Bgenetic
27708008
NDH2_YEASTNDE2genetic
27708008
PHO2_YEASTPHO2genetic
27708008
RL35A_YEASTRPL35Agenetic
27708008
RL35B_YEASTRPL35Agenetic
27708008
AIM7_YEASTAIM7genetic
27708008
LIC4_YEASTATC1genetic
27708008
GNTK_YEASTYDR248Cgenetic
27708008
MRB1_YEASTPHO92genetic
27708008
AIM11_YEASTAIM11genetic
27708008
YG036_YEASTYGL036Wgenetic
27708008
MON1_YEASTMON1genetic
27708008
DSD1_YEASTDSD1genetic
27708008
SLX9_YEASTSLX9genetic
27708008
RL11B_YEASTRPL11Bgenetic
27708008
ASK10_YEASTASK10genetic
27708008
UBR1_YEASTUBR1genetic
27708008
SODM_YEASTSOD2genetic
27708008
AIM18_YEASTAIM18genetic
27708008
SDS3_YEASTSDS3genetic
27708008
QDR1_YEASTQDR1genetic
27708008
YKF0_YEASTYKL050Cgenetic
27708008
MDM35_YEASTMDM35genetic
27708008
EF1G2_YEASTTEF4genetic
27708008
SRX1_YEASTSRX1genetic
27708008
YKZ5_YEASTYKR015Cgenetic
27708008
BCH2_YEASTBCH2genetic
27708008
RL8B_YEASTRPL8Bgenetic
27708008
SPSY_YEASTSPE4genetic
27708008
RNH2C_YEASTRNH203genetic
27708008
SWI6_YEASTSWI6genetic
27708008
ECM22_YEASTECM22genetic
27708008
YL287_YEASTYLR287Cgenetic
27708008
YL415_YEASTYLR415Cgenetic
27708008
YL422_YEASTYLR422Wgenetic
27708008
YOX1_YEASTYOX1genetic
27708008
ARMT1_YEASTYMR027Wgenetic
27708008
MSS11_YEASTMSS11genetic
27708008
GCSP_YEASTGCV2genetic
27708008
PABC_YEASTABZ2genetic
27708008
ATP23_YEASTATP23genetic
27708008
IRA2_YEASTIRA2genetic
27708008
INO4_YEASTINO4genetic
27708008
KIN4_YEASTKIN4genetic
27708008
SPS4_YEASTSPS4genetic
27708008
SVL3_YEASTSVL3genetic
27708008
SUR1_YEASTSUR1genetic
27708008
RL21B_YEASTRPL21Bgenetic
27708008
BECN1_YEASTVPS30genetic
27708008
KES1_YEASTKES1genetic
27708008
RTC6_YEASTRTC6genetic
27708008
YMC1_YEASTYMC1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DLS1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17, AND MASSSPECTROMETRY.

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