FRE5_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FRE5_YEAST
• UniProt AC: Q08908
• Protein Name: Ferric reductase transmembrane component 5
• Gene Name: FRE5
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 694
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Metalloreductase responsible for reducing extracellular iron and copper prior to import. Catalyzes the reductive uptake of Fe(3+)-salts and Fe(3+) bound to catecholate or hydroxamate siderophores. Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane (By similarity)..
• Protein Sequence: MLFARLVLLLVYLAPGSLAKPASTKKRTQWDQIAIDACAKELESHKFDTDVKGRHATLCTYEPALGSWLHCAKDVLDSRKKSKKIFEKTFSKINQYCHDYHKDEVVSNEEYYRIFANASLFIRPLDEVKENIRYPVTPNKASLDRWVWAYFGPLDNIDKGNVYGVTICLYWIGVLFIAAVYHFLNFSRLKQTVFKNKVSAFLRGHYVLPALVHNHAMSVGRWFFIGLVPTRLETLVLFGYVLLHGFLLSSYNFDHNELLSDRRSQVLIFLSDRAGILAFAHFPLIVLFGGKNSTMTWLTGIRYTAFITYHKWLGRFMLVDCTIHAIGYTYHAYIENYWKYVKYSDLWTSGRHAMIIVGILVFFSFFFFRRHYYELFVITHIILAIGFFHACWKHCYKLGWGEWIMACALFWIADRILRLIKIAIFGMPWAKLKLCGESMIEVRISKSSKWWKAEPGQYIYLYFLRPKIFWQSHPFTVMDSLVEDGELVVVITVKNGLTKKLQEYLLESEGYTEMRVLAEGPYGQSTRTHLFESLLFIAGGAGVPGPLSMAIKAGRQVKSNDSHQMIKFVWSVRNLDLLEVYRKEIMVLKELNIDTKIYFTGERKDESNTEEGAIANMSTEGRLLTTSKSAEMITDFGRPNIDEIIEEAVSGAKSLLVTCCGSEGFVDKTRELTAKRVLEHGDKWIEYVEEFQNW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
111	Phosphorylation	EVVSNEEYYRIFANA CCCCCHHHHHHHHCC	7.58	30377154
117	N-linked_Glycosylation	EYYRIFANASLFIRP HHHHHHHCCCEEECC	21.22	-
134	Phosphorylation	EVKENIRYPVTPNKA HHHHHCCCCCCCCCH	9.77	25882841
508	Phosphorylation	LQEYLLESEGYTEMR HHHHHHHCCCCCEEE	35.97	19779198
512	Phosphorylation	LLESEGYTEMRVLAE HHHCCCCCEEEEEEE	33.87	19779198
525	Phosphorylation	AEGPYGQSTRTHLFE EECCCCHHHHHHHHH	18.59	19779198
526	Phosphorylation	EGPYGQSTRTHLFES ECCCCHHHHHHHHHH	31.53	28889911
662	Phosphorylation	LLVTCCGSEGFVDKT CHHHHHCCCCCCHHH	22.19	30377154

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FRE5_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FRE5_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FRE5_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TECR_YEAST	TSC13	genetic	27708008
TAF12_YEAST	TAF12	genetic	27708008
ACT_YEAST	ACT1	genetic	27708008
SWC4_YEAST	SWC4	genetic	27708008
CYAA_YEAST	CYR1	genetic	27708008
NTR2_YEAST	NTR2	genetic	27708008
SEC22_YEAST	SEC22	genetic	27708008
TYSY_YEAST	CDC21	genetic	27708008
TBF1_YEAST	TBF1	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.